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Natural antimicrobials to reduce enteric pathogens

LSHTM staff: Ozan Gundogdu
Funding:  AFBI NI
Collaborators: AFBI NI 

Removal of zinc oxide from pig diets: mechanisms to reducing pathogens and AMR

LSHTM staff: Ozan Gundogdu
Funding: DAERA
Collaborators: AFBI NI (lead institute)
Project duration: 2019-2022

Influencing new born piglets microbiota: an innovative and applied approach to reducing pathogens and AMR

LSHTM staff: Ozan Gundogdu
Funding: DAERA
Collaborators: AFBI NI (lead institute)
Project duration: 2020-2022

MBIRA (Mortality from Bacterial Infections Resistant to Antibiotics)

Whilst AMR is a global issue, it has major implications for African countries where severe bacterial infections are common but access to effective antibiotic treatment remains limited. To date, we lack reliable estimates of the impact of AMR in LMIC settings, which limits our capacity to address the increasing threat.

The MBIRA project is the first multi-national prospective observational study to better understand the mortality burden due to AMR in bloodstream infections in sub-Saharan Africa. The project is focussed on bacteraemia caused by Gram-negative enteric bacteria and includes patients of all age groups, from neonates to adults. The aim is to gather data across 9 hospitals in sub-Saharan Africa to inform larger global burden of disease analyses.

LSHTM staff: Alex Aiken, Andrea Rehman
Funding: Bill & Melinda Gates Foundation, Fleming Fund
Collaborators: Centre for Infectious Disease Research in Zambia (Lusaka, Zambia), Haramaya University (Harar, Ethiopia), Kilimanjaro Clinical Research Institute (Moshi, Tanzania), KEMRI-Wellcome Trust Research Programme (Kilifi, Kenya), Malawi-Liverpool-Wellcome Trust Clinical Research Programme (Blantyre, Malawi), National Hospital Abuja (Abuja, Nigeria), Stellenbosch University (Stellenbosch, South Africa), University of Ghana Medical School (Accra, Ghana), Université des Sciences, des Techniques et des Technologies de Bamako (Bamako, Mali).
Project duration: October 2019 – March 2022

Regulating e-pharmacy: challenges and opportunities for access and quality of care in LMIC health systems

The study aims to assess the performance of e-pharmacies in India and Kenya, analyse the systems that regulate them, and identify opportunities for improving medicine quality, safety and accessibility.

LSHTM staff: Catherine Goodman, Rosalind Miller
Funding: HSRI
Collaborators: Strathmore Business School (Kenya), The George Institute (India)
Project duration: 2021-2024

Antibiotic stewardship in agricultural communities in Africa and Asia: A unified One Health strategy to optimise antibiotic use in animals and humans

This is a cluster project that seeks to compare and contrast emerging knowledge from recent and ongoing research across selected countries in Africa, Asia and South America about antibiotic usage and its drivers in humans and animals in agricultural communities and identify key priorities, potential points of nexus and barriers and enablers in order to facilitate the design of novel interventions with a common overarching strategy and contextual adaptations.

LSHTM staff: Sian Clarke, Meenakshi Gautham, Eleanor Hutchinson, Catherine Goodman, Mishal Khan, Johanna Hanefield, Harprakash Kaur
Funding: GCRF Cluster Scheme
Collaborators: University of Glasgow, UK (Tiziana Lembo), RVC, UK (Pablo Alarcon, Ana Mateus, Fiona Tomlin), West Bengal University for Animal and Fishery Sciences, India (Indranil Samanta), Makarere University, Uganda (Freddy Kitutu, Anthony Mbonye), Universidad Antonio Narino, Colombia (Nelson Arenas)
Project duration: June 2020 - May 2021

A multi-stakeholder approach towards operationalising antibiotic stewardship in India’s pluralistic rural health system

The main aims of the study are to engage with multiple stakeholders and co-design and implement (on a small scale) an intervention to operationalise antibiotic stewardship for human and livestock health in rural community settings in India. The intervention design will draw on formative research conducted with rural households, informal and formal primary care providers, veterinarians and paravets, health and regulatory department stakeholders, and stakeholders in pharmaceutical value chains in rural West Bengal, supplemented by an online survey of primary care physicians, informal providers, vets and paravets on their SARS-CoV-2-related practices, including use of antibiotics.

LSHTM staff: Meenakshi Gautham,  Catherine Goodman, Richard Stabler
Funding: MRC (HSRI)
Collaborators: Royal Veterinary College (Pablo Alarcon and Ana Mateus), Institute of Development Studies (Gerald Bloom and Ayako Ebata), Public Health Foundation of India (Prof. Srinath Reddy, Sanghita Bhattacharyya, Sandeep Bhalla), West Bengal University for Animal and Fishery Sciences (Indranil Samanta)
Project duration: Feb 2018 - Jan 2022

WASH and biosecurity interventions for reducing burdens of infection, antibiotic use and antimicrobial resistance

This mixed methods systematic review is investigating how water, sanitation and hygiene (WASH) and biosecurity interventions could reduce infections, antimicrobial use and antimicrobial resistance (AMR) in people working in close contact with animals, such as farmers. This project will consider different settings, with a focus on low- and middle-income countries. Previous research has suggested that social, cultural, political, economic and environmental factors play an important role in the development of AMR, however, it is not well-understood how these effects can be mitigated. This systematic review, in collaboration with the LSHTM AMR Centre and the International Livestock Research Institute (ILRI), will summarise the evidence base for such structural AMR interventions, with the aim of shaping future research, policies and funding in this area.

LSHTM staff: Chris Pinto, Clare Chandler, Sarai Keestra
Funding: CGIAR
Collaborators: ILRI
Project duration: 2019-2021

OneHealth Poultry Hub

LSHTM staff: Brendan Wren, Richard Stabler
Funding: GCRF
Collaborators: RVC
Project duration: 2019-2024