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WASH and biosecurity interventions for reducing burdens of infection, antibiotic use and antimicrobial resistance

This mixed methods systematic review is investigating how water, sanitation and hygiene (WASH) and biosecurity interventions could reduce infections, antimicrobial use and antimicrobial resistance (AMR) in people working in close contact with animals, such as farmers. This project will consider different settings, with a focus on low- and middle-income countries. Previous research has suggested that social, cultural, political, economic and environmental factors play an important role in the development of AMR, however, it is not well-understood how these effects can be mitigated. This systematic review, in collaboration with the LSHTM AMR Centre and the International Livestock Research Institute (ILRI), will summarise the evidence base for such structural AMR interventions, with the aim of shaping future research, policies and funding in this area.

LSHTM staff: Chris Pinto, Clare Chandler, Sarai Keestra
Funding: CGIAR
Collaborators: ILRI
Project duration: 2019-2021

OneHealth Poultry Hub

LSHTM staff: Brendan Wren, Richard Stabler
Funding: GCRF
Collaborators: RVC
Project duration: 2019-2024

COVID-19 and antimicrobial resistance

Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. It has not gone away. Instead, the challenges of AMR now need to be seen through the lens of changing healthcare landscapes due to COVID-19.

LSHTM staff: Finn McQuaid, Rebecca Glover, Quentin leclerc, Karin Gallandat, Naomi Fuller, Sam Willcocks, Esther van Kleef
Project duration: 2020

TB-drug resistance: impact of pre-clinical resistance mutations

LSHTM staff: Naomi Fuller, Gwen Knight
Funding: LiDO studentship
Collaborators: Tim McHugh (UCL)
Project duration: 2020 - 2023

Bacteriophage - generalised transduction modelling

LSHTM staff: Quentin Leclerc, Gwen Knight
Funding: MRC LID studentship
Collaborators: Jodi Lindsay (St George's)
Project duration: 2018 - 2022

Is transmission of drug-resistant Mycobacterium tuberculosis increasing or decreasing?

LSHTM staff: Finn McQuaid, Rein Houben, Gwen Knight, Richard White
Collaborators: Anna Dean, Matteo Zignol (WHO), Ted Cohen (Yale)

The risk of multidrug or rifampicin-resistance in men versus women with TB

LSHTM staff: Finn McQuaid, Katherine Horton, Gwen Knight, Richard White
Collaborators: Anna Dean (WHO)

Combating MRSA; increasing our understanding of transmission success will lead to better control of MRSA

LSHTM staff: Gwen Knight, Anneke de Vos
Funding: JPIAMR EU
Collaborators: ERASMUS Netherlands
Project duration: 2017 - 2020