WASH and biosecurity interventions for reducing burdens of infection, antibiotic use and antimicrobial resistance
This mixed methods systematic review is investigating how water, sanitation and hygiene (WASH) and biosecurity interventions could reduce infections, antimicrobial use and antimicrobial resistance (AMR) in people working in close contact with animals, such as farmers. This project will consider different settings, with a focus on low- and middle-income countries. Previous research has suggested that social, cultural, political, economic and environmental factors play an important role in the development of AMR, however, it is not well-understood how these effects can be mitigated. This systematic review, in collaboration with the LSHTM AMR Centre and the International Livestock Research Institute (ILRI), will summarise the evidence base for such structural AMR interventions, with the aim of shaping future research, policies and funding in this area.
LSHTM staff: Chris Pinto, Clare Chandler, Sarai Keestra
Funding: CGIAR
Collaborators: ILRI
Project duration: 2019-2021
LY256: A novel and potent antibiotic for treating Clostridium difficile infection
LSHTM staff: Brendan Wren, Lisa Dawson
Funding: MRC
Collaborators: University of Nottingham
Project duration: 2018-2021
OneHealth Poultry Hub
LSHTM staff: Brendan Wren, Richard Stabler
Funding: GCRF
Collaborators: RVC
Project duration: 2019-2024
Therapeutic development for Acinetobacter baumannii
LSHTM staff: Brendan Wren, Richard Stabler
Funding: MRC
Collaborators: UCL
Project duration: 2018-2022
COVID-19 and antimicrobial resistance
Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. It has not gone away. Instead, the challenges of AMR now need to be seen through the lens of changing healthcare landscapes due to COVID-19.
LSHTM staff: Finn McQuaid, Rebecca Glover, Quentin leclerc, Karin Gallandat, Naomi Fuller, Sam Willcocks, Esther van Kleef
Project duration: 2020
TB-drug resistance: impact of pre-clinical resistance mutations
LSHTM staff: Naomi Fuller, Gwen Knight
Funding: LiDO studentship
Collaborators: Tim McHugh (UCL)
Project duration: 2020 - 2023
Bacteriophage - generalised transduction modelling
LSHTM staff: Quentin Leclerc, Gwen Knight
Funding: MRC LID studentship
Collaborators: Jodi Lindsay (St George's)
Project duration: 2018 - 2022
Is transmission of drug-resistant Mycobacterium tuberculosis increasing or decreasing?
LSHTM staff: Finn McQuaid, Rein Houben, Gwen Knight, Richard White
Collaborators: Anna Dean, Matteo Zignol (WHO), Ted Cohen (Yale)
The risk of multidrug or rifampicin-resistance in men versus women with TB
LSHTM staff: Finn McQuaid, Katherine Horton, Gwen Knight, Richard White
Collaborators: Anna Dean (WHO)
Combating MRSA; increasing our understanding of transmission success will lead to better control of MRSA
LSHTM staff: Gwen Knight, Anneke de Vos
Funding: JPIAMR EU
Collaborators: ERASMUS Netherlands
Project duration: 2017 - 2020