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Antibiotic stewardship in agricultural communities in Africa and Asia: A unified One Health strategy to optimise antibiotic use in animals and humans

This is a cluster project that seeks to compare and contrast emerging knowledge from recent and ongoing research across selected countries in Africa, Asia and South America about antibiotic usage and its drivers in humans and animals in agricultural communities and identify key priorities, potential points of nexus and barriers and enablers in order to facilitate the design of novel interventions with a common overarching strategy and contextual adaptations.

LSHTM staff: Sian Clarke, Meenakshi Gautham, Eleanor Hutchinson, Catherine Goodman, Mishal Khan, Johanna Hanefield, Harprakash Kaur
Funding: GCRF Cluster Scheme
Collaborators: University of Glasgow, UK (Tiziana Lembo), RVC, UK (Pablo Alarcon, Ana Mateus, Fiona Tomlin), West Bengal University for Animal and Fishery Sciences, India (Indranil Samanta), Makarere University, Uganda (Freddy Kitutu, Anthony Mbonye), Universidad Antonio Narino, Colombia (Nelson Arenas)
Project duration: June 2020 - May 2021

A multi-stakeholder approach towards operationalising antibiotic stewardship in India’s pluralistic rural health system

The main aims of the study are to engage with multiple stakeholders and co-design and implement (on a small scale) an intervention to operationalise antibiotic stewardship for human and livestock health in rural community settings in India. The intervention design will draw on formative research conducted with rural households, informal and formal primary care providers, veterinarians and paravets, health and regulatory department stakeholders, and stakeholders in pharmaceutical value chains in rural West Bengal, supplemented by an online survey of primary care physicians, informal providers, vets and paravets on their SARS-CoV-2-related practices, including use of antibiotics.

LSHTM staff: Meenakshi Gautham,  Catherine Goodman, Richard Stabler
Funding: MRC (HSRI)
Collaborators: Royal Veterinary College (Pablo Alarcon and Ana Mateus), Institute of Development Studies (Gerald Bloom and Ayako Ebata), Public Health Foundation of India (Prof. Srinath Reddy, Sanghita Bhattacharyya, Sandeep Bhalla), West Bengal University for Animal and Fishery Sciences (Indranil Samanta)
Project duration: Feb 2018 - Jan 2022

WASH and biosecurity interventions for reducing burdens of infection, antibiotic use and antimicrobial resistance

This mixed methods systematic review is investigating how water, sanitation and hygiene (WASH) and biosecurity interventions could reduce infections, antimicrobial use and antimicrobial resistance (AMR) in people working in close contact with animals, such as farmers. This project will consider different settings, with a focus on low- and middle-income countries. Previous research has suggested that social, cultural, political, economic and environmental factors play an important role in the development of AMR, however, it is not well-understood how these effects can be mitigated. This systematic review, in collaboration with the LSHTM AMR Centre and the International Livestock Research Institute (ILRI), will summarise the evidence base for such structural AMR interventions, with the aim of shaping future research, policies and funding in this area.

LSHTM staff: Chris Pinto, Clare Chandler, Sarai Keestra
Funding: CGIAR
Collaborators: ILRI
Project duration: 2019-2021

OneHealth Poultry Hub

LSHTM staff: Brendan Wren, Richard Stabler
Funding: GCRF
Collaborators: RVC
Project duration: 2019-2024

COVID-19 and antimicrobial resistance

Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. It has not gone away. Instead, the challenges of AMR now need to be seen through the lens of changing healthcare landscapes due to COVID-19.

LSHTM staff: Finn McQuaid, Rebecca Glover, Quentin leclerc, Karin Gallandat, Naomi Fuller, Sam Willcocks, Esther van Kleef
Project duration: 2020

TB-drug resistance: impact of pre-clinical resistance mutations

LSHTM staff: Naomi Fuller, Gwen Knight
Funding: LiDO studentship
Collaborators: Tim McHugh (UCL)
Project duration: 2020 - 2023

Bacteriophage - generalised transduction modelling

LSHTM staff: Quentin Leclerc, Gwen Knight
Funding: MRC LID studentship
Collaborators: Jodi Lindsay (St George's)
Project duration: 2018 - 2022

Is transmission of drug-resistant Mycobacterium tuberculosis increasing or decreasing?

LSHTM staff: Finn McQuaid, Rein Houben, Gwen Knight, Richard White
Collaborators: Anna Dean, Matteo Zignol (WHO), Ted Cohen (Yale)