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Blood-samples. Credit: Antonio Mendes

Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE)

FIEBRE aims to reveal leading causes of fever in sub-Saharan Africa and southeast Asia. What are the main infections causing fever in children and adults, and how should they be treated?

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About us

Rapid diagnostic testing for malaria has revealed that most febrile patients in Africa and Asia do not have malaria. FIEBRE will find out what they have and how to treat them.

Who we are

Funded by the UK Department for International Development, FIEBRE collaborators include LSHTM, Liverpool School of Tropical Medicine, Universities of Oxford, Barcelona and Otago, and partners in Laos, Malawi, Mozambique, Myanmar and Zimbabwe.


Study protocols, standard operating procedures, data collection tools and related materials will be made available as they are finalised and approved.


The objective of FIEBRE is to provide evidence:

  • on the most common infectious causes of fever;
  • on antibiotic susceptibility of bacterial causes;
  • on how local perceptions of fever affect treatment practices including the use of diagnostics and antimicrobial drugs;
  • to inform clinical guidelines and algorithms on how to manage non-malarial fevers.

The FIEBRE study will help to fill the gaps in evidence by means of a multi-centre study in countries with a high burden of infectious disease from which few or no data are available. The clinical and laboratory components of the study will focus on detecting infections that are treatable and/or preventable. Ethnographic work with community members, prescribers and public health workers will seek to understand how fever is understood by different communities of practice, and how this affects treatment practices.

The results will help to inform updated, evidence-based algorithms for the management of febrile illness, and provide data that may be used to design new diagnostics and rational approaches to disease surveillance. These outputs will ultimately help health systems and providers to provide more appropriate care to patients and lead to better clinical outcomes.

Who we are
Who we are FIEBRE

FIEBRE is funded by the UK Department for International Development. It is a multi-centre study conducted by the LSHTM, Liverpool School of Tropical Medicine, Universities of Oxford, Barcelona and Otago, and partner institutions in Lao PDR, Malawi, Mozambique, Myanmar and Zimbabwe, and collaborating reference laboratories.


Country partners


Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)


Malawi-Liverpool Wellcome Trust Research Programme (MLW)


Centro de Investigacao em Saude de Manhica (CISM)


University of Medicine 1 Yangon


Biomedical Research and Training Institute (BRTI), Zimbabwe

Publications List Block
Addressing Antimicrobial Resistance Through Social Theory: An Anthropologically Oriented Report.
Chandler, C; Hutchinson, E; Hutchison, C
Technical Report. London School of Hygiene & Tropical Medicine
Estimating the Burden of Febrile Illnesses
Crump JA, Kirk MD.
PLoS Negl Trop Dis; 9(12): e0004040
Etiology of Severe Febrile Illness in Low- and Middle-Income Countries: A Systematic Review
Prasad N, Murdoch DR, Reyburn H, Crump JA.
PLoS One; 10(6): e0127962
Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study
Crump JA, Morrissey AB, Nicholson WL, et al.
PLoS Negl Trop Dis; 7(7): e2324
Causes of non-malarial fever in Laos: a prospective study
Mayxay M, Castonguay-Vanier J, Chansamouth V, et al.
Lancet Glob Health; 1(1): e46-54
Estimating the incidence of typhoid fever and other febrile illnesses in developing countries
Crump JA, Youssef FG, Luby SP, et al.
Emerg Infect Dis; 9(5): 539-44