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Ms Tegwen Marlais

PhD

Research Fellow

Room
266

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I am a Research Fellow in the Clinical Research Department.

I have a background in parasitology and diagnostics development for infectious diseases, particularly immunodiagnostics.

I currently work on a study called Markers of Severity Diagnostics for Evaluating Fever (Mos-Def) which is nested within the large multi-country FIEBRE study on fever aetiology. My work involves developing a multiplex bead-based immunoassay on the Luminex platform to detect molecules released by the immune system during infection. By quantifying these markers in blood samples from the FIEBRE study, we will analyse which markers are useful to provide a prognosis for fever cases and which markers can differentiate between causes of fever such as bacterial, viral or parasitic.

My PhD, at LSHTM, was on diagnostics development for two parasitic infections: strongyloidiasis caused by the nematode (worm) Strongyloides stercoralis, and visceral leishmaniasis caused by the protozoan Leishmania. This included laboratory and field work in India and Guinea Bissau, as well as computational methods of antigen discovery using large open-access data sets such as genomes, proteomes and transcriptomes.

In addition to my research work, I act as a personal tutor to students on the MSc Control of Infectious Diseases, co-supervise a PhD student and MSc research projects, act as a tutor for Distance Learning module Biology of Infectious Diseases and sit on the exam board for MSc One Health. I am currently studying for the Post Graduate Certificate in Learning and Teaching (PG-CILT).

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Research

Research Area
Diagnostics
Helminths
Parasites
Trypanosomes
Protozoa
Discipline
Genomics
Epidemiology
Molecular biology
Parasitology
Vector biology
Bioinformatics
Entomology
Disease and Health Conditions
Leishmaniasis
Chagas Disease
Neglected Tropical Diseases (NTDs)
Sepsis
Tropical diseases
Vector borne disease
Zoonotic disease
Soil-transmitted helminths
Country
Brazil
Guinea-Bissau
India
Lao PDR
Mozambique
Malawi
Nepal
Sudan
Zimbabwe
Region
Latin America & Caribbean (all income levels)
South Asia
Sub-Saharan Africa (developing only)

Selected Publications

Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis.
Bremer Hinckel BC; Marlais T; Airs S; Bhattacharyya T; Imamura H; Dujardin J-C; El-Safi S; Singh OP; Sundar S; Falconar AK
2019
PLoS neglected tropical diseases
Visceral Leishmaniasis IgG1 Rapid Monitoring of Cure vs. Relapse, and Potential for Diagnosis of Post Kala-Azar Dermal Leishmaniasis.
Marlais T; Bhattacharyya T; Singh OP; Mertens P; Gilleman Q; Thunissen C; Hinckel BCB; Pearson C; Gardner BL; Airs S
2018
Frontiers in Cellular and Infection Microbiology
Detection of Immunoglobulin G1 Against rK39 Improves Monitoring of Treatment Outcomes in Visceral Leishmaniasis.
Mollett G; Bremer Hinckel BC; Bhattacharyya T; Marlais T; Singh OP; Mertens P; Falconar AK; El-Safi S; Sundar S; Miles MA
2018
Clinical Infectious Diseases
Diagnostic antigens for visceral leishmaniasis: clarification of nomenclatures.
Bhattacharyya T; Marlais T; Miles MA
2017
Parasites & vectors
StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control.
Albonico M; Becker SL; Odermatt P; Angheben A; Anselmi M; Amor A; Barda B; Buonfrate D; Cooper P; G├ętaz L
2016
PLoS neglected tropical diseases
Clinical Research on Neglected Tropical Diseases: Challenges and Solutions.
Boelaert M; NIDIAG Consortium
2016
PLoS neglected tropical diseases
See more Publications