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Dr Katharina Kranzer

FRCPath MRCP MBBS MSc MSc PhD

Associate Professor
Infectious Disease Epidemiology

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2116

Following my specialist registrar training in Clinical Microbiology and Virology in London in 2015 I became clinical director of the Supranational and National Tuberculosis Reference Laboratory in Germany. I have trained as an epidemiologist at the London School of Hygiene and Tropical Medicine in 2007, followed by a Wellcome Trust funded PhD. During my PhD I investigated the role of active case finding and antiretroviral therapy for tuberculosis control in high HIV and TB prevalence settings in South Africa. I continued to work in sub-Saharan Africa with my research mainly focusing on tuberculosis and HIV, including specifically interventions to improve linkage to care, operational and implementation research and diagnostics. More recently my role as director of the WHO Supranational Tuberculosis Reference Laboratory my research interests have expanded to multi-drug resistant tuberculosis in Eastern Europe and Central Asia, as well as laboratory quality management and laboratory networks.

My research to date has informed WHO Guidelines on “Systematic Screening for Active Tuberculosis” and “Management if Latent Tuberculosis Infection”. I have served on several WHO expert panels and provided expert advice to the European Centre of Disease Control and national public health institutions such as the Robert Koch Institute.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Centres

Tuberculosis (TB) Centre

Teaching

I am a tutor on the tuberculosis module for the MSc Infectious Diseases by Distance Learning and for the MSc Epidemiology by Distance Learning. I co-organise and teach on the AIDS module in London. Furthermore I am a member of the faculty of the NIH Fogarthy Training for Research Excellence and Mentorship in Tuberculosis Program (TRENT).

I am particularly committed to capacity building. In my role as the director of the WHO Supranational Tuberculosis Reference Laboratory we partnered with national and regional laboratories in Moldova, Azerbaijan, Armenia, Sierra Leone, Pakistan and Ghana. Together with members of my team I regularly conducted supervisory visits in country and delivered teaching on new (molecular) diagnostics, quality managements and laboratory information systems.

Research

My research interest is focused on improving diagnosis and treatment of drug susceptible and resistant tuberculosis. My particular interest are rapid diagnostics, tuberculosis control, multi-drug resistant tuberculosis, HIV-associated tuberculosis and laboratory capacity. I am also interested in operational research aimed at improving the cascade of care both for tuberculosis as well as HIV.

 

Research Area
Bacteria
Clinical care
Clinical guidelines
Clinical trials
Diagnostics
Adolescent health
Disease control
Global Health
Implementation research
Discipline
Bacteriology
Epidemiology
Medicine
Microbiology
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Country
Pakistan
Zimbabwe
Region
South Asia
Sub-Saharan Africa (all income levels)
World

Selected Publications

Can tuberculosis patients in resource-constrained settings afford chest radiography?
Pedrazzoli, D. ; Lalli, M. ; Boccia, D. ; Houben, R. ; Kranzer, K. ;
2017
Eur Respir J
Challenges in the Estimation of the Annual Risk of Mycobacterium tuberculosis Infection in Children Aged Less Than 5 Years.
Khan, P.Y. ; Glynn, J.R. ; Mzembe, T. ; Mulawa, D. ; Chiumya, R. ; Crampin, A.C. ; Kranzer, K. ; Fielding, K.L. ;
2017
Am J Epidemiol
How should discordance between molecular and growth-based assays for rifampicin resistance be investigated?
Hofmann-Thiel, S. ; Hoffmann, H. ; Hillemann, D. ; Rigouts, L. ; Van Deun, A. ; Kranzer, K. ;
2017
Int J Tuberc Lung Dis
Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis.
Kodama, C. ; Lange, B. ; Olaru, I.D. ; Khan, P. ; Lipman, M. ; Seddon, J.A. ; Sloan, D. ; Grandjean, L. ; Ferrand, R.A. ; Kranzer, K. ;
2017
Eur Respir J
Economic incentives for HIV testing by adolescents in Zimbabwe: a randomised controlled trial.
Kranzer, K. ; Simms, V. ; Bandason, T. ; Dauya, E. ; McHugh, G. ; Munyati, S. ; Chonzi, P. ; Dakshina, S. ; Mujuru, H. ; Weiss, H.A. ; Ferrand, R.A. ;
2017
Lancet HIV
Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial.
Gonzalez-Martinez, C. ; Kranzer, K. ; McHugh, G. ; Corbett, E.L. ; Mujuru, H. ; Nicol, M.P. ; Rowland-Jones, S. ; Rehman, A.M. ; Gutteberg, T.J. ; Flaegstad, T. ; Odland, J.O. ; Ferrand, R.A. ; BREATHE study team, . ; COLLABORATORS;Bandason, T. ; Cavanagh, P. ; Dauya, E. ; Majonga, E. ; Makamure, B. ; Mapurisa, G.N. ; Mbhele, S. ; Moyo, B.W. ; Ngwira, L.G. ; Rylance, J. ; Simms, V. ; Sovershaeva, E. ; Weiss, H.A. ; Yindom, L.M. ;
2017
Trials
See all Dr Katharina Kranzer's Publications