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Dr Katharina Kranzer

FRCPath MRCP MBBS MSc MSc PhD

Associate Professor
Infectious Disease Epidemiology

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2116

Following my specialist registrar training in Clinical Microbiology and Virology in London in 2015 I became clinical director of the Supranational and National Tuberculosis Reference Laboratory in Germany. I have trained as an epidemiologist at the London School of Hygiene and Tropical Medicine in 2007, followed by a Wellcome Trust funded PhD. During my PhD I investigated the role of active case finding and antiretroviral therapy for tuberculosis control in high HIV and TB prevalence settings in South Africa. I continued to work in sub-Saharan Africa with my research mainly focusing on tuberculosis and HIV, including specifically interventions to improve linkage to care, operational and implementation research and diagnostics. More recently my role as director of the WHO Supranational Tuberculosis Reference Laboratory my research interests have expanded to multi-drug resistant tuberculosis in Eastern Europe and Central Asia, as well as laboratory quality management and laboratory networks.

My research to date has informed WHO Guidelines on “Systematic Screening for Active Tuberculosis” and “Management if Latent Tuberculosis Infection”. I have served on several WHO expert panels and provided expert advice to the European Centre of Disease Control and national public health institutions such as the Robert Koch Institute.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Tuberculosis (TB) Centre

Teaching

I am a tutor on the tuberculosis module for the MSc Infectious Diseases by Distance Learning and for the MSc Epidemiology by Distance Learning. I co-organise and teach on the AIDS module in London. Furthermore I am a member of the faculty of the NIH Fogarthy Training for Research Excellence and Mentorship in Tuberculosis Program (TRENT).

I am particularly committed to capacity building. In my role as the director of the WHO Supranational Tuberculosis Reference Laboratory we partnered with national and regional laboratories in Moldova, Azerbaijan, Armenia, Sierra Leone, Pakistan and Ghana. Together with members of my team I regularly conducted supervisory visits in country and delivered teaching on new (molecular) diagnostics, quality managements and laboratory information systems.

Research

My research interest is focused on improving diagnosis and treatment of drug susceptible and resistant tuberculosis. My particular interest are rapid diagnostics, tuberculosis control, multi-drug resistant tuberculosis, HIV-associated tuberculosis and laboratory capacity. I am also interested in operational research aimed at improving the cascade of care both for tuberculosis as well as HIV.

 

Research Area
Bacteria
Clinical care
Clinical guidelines
Clinical trials
Diagnostics
Adolescent health
Disease control
Global Health
Implementation research
Discipline
Bacteriology
Epidemiology
Medicine
Microbiology
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Country
Pakistan
Zimbabwe
Region
South Asia
Sub-Saharan Africa (all income levels)
World

Selected Publications

Differential drug susceptibility patterns of Mycobacterium chimaera and other members of the Mycobacterium avium-intracellulare complex.
Maurer FP; Pohle P; Kernbach M; Sievert D; Hillemann D; Rupp J; Hombach M; Kranzer K
2018
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Impact of quality improvement in tuberculosis laboratories in low- and lower-middle-income countries: a systematic review
Olaru ID; Albert H; Zallet J; Werner U-E; Ahmed N; Rieder HL; Salfinger M; Kranzer K
2018
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Community burden of undiagnosed HIV infection among adolescents in Zimbabwe following primary healthcare-based provider-initiated HIV testing and counselling: A cross-sectional survey.
Simms V; Dauya E; Dakshina S; Bandason T; McHugh G; Munyati S; Chonzi P; Kranzer K; Ncube G; Masimirembwa C
2017
PLoS medicine
Loss to follow-up among children and adolescents growing up with HIV infection: age really matters.
Kranzer K; Bradley J; Musaazi J; Nyathi M; Gunguwo H; Ndebele W; Dixon M; Ndhlovu M; Rehman A; Khan P
2017
Journal of the International AIDS Society
HIV-Associated Chronic Lung Disease in Children and Adolescents in Zimbabwe: Chest Radiographic and High-Resolution Computed Tomography Findings.
Desai SR; Nair A; Rylance J; Mujuru H; Nathoo K; McHugh G; Majonga E; Metcalfe J; Kranzer K; Ferrand RA
2017
Clinical infectious diseases
Economic incentives for HIV testing by adolescents in Zimbabwe: a randomised controlled trial.
Kranzer K; Simms V; Bandason T; Dauya E; McHugh G; Munyati S; Chonzi P; Dakshina S; Mujuru H; Weiss HA
2017
The lancet HIV
Can tuberculosis patients in resource-constrained settings afford chest radiography?
Pedrazzoli D; Lalli M; Boccia D; Houben R; Kranzer K
2017
The European respiratory journal
Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis.
Kodama C; Lange B; Olaru ID; Khan P; Lipman M; Seddon JA; Sloan D; Grandjean L; Ferrand RA; Kranzer K
2017
The European respiratory journal
How should discordance between molecular and growth-based assays for rifampicin resistance be investigated?
Hofmann-Thiel S; Hoffmann H; Hillemann D; Rigouts L; Van Deun A; Kranzer K
2017
The international journal of tuberculosis and lung disease
The effectiveness of Routine Opt-out HIV Testing for children in Harare, Zimbabwe.
Ferrand RA; Meghji J; Kidia K; Dauya E; Bandason T; Mujuru H; Ncube G; Mungofa S; Kranzer K
2016
Journal of acquired immune deficiency syndromes (1999)
Uptake and yield of HIV testing and counselling among children and adolescents in sub-Saharan Africa: a systematic review.
Govindasamy D; Ferrand RA; Wilmore SM; Ford N; Ahmed S; Afnan-Holmes H; Kranzer K
2015
Journal of the International AIDS Society
Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries.
Getahun H; Matteelli A; Abubakar I; Aziz MA; Baddeley A; Barreira D; Den Boon S; Borroto Gutierrez SM; Bruchfeld J; Burhan E
2015
The European respiratory journal
Maximising the benefits of home-based HIV testing.
Ferrand R; Ford N; Kranzer K
2014
The lancet HIV
Strength of recommendations in WHO guidelines using GRADE was associated with uptake in national policy.
Nasser SM; Cooke G; Kranzer K; Norris SL; Olliaro P; Ford N
2014
Journal of clinical epidemiology
Community viral load and CD4 count distribution among people living with HIV in a South African township: implications for treatment as prevention.
Kranzer K; Lawn SD; Johnson LF; Bekker LG; Wood R
2013
Journal of acquired immune deficiency syndromes (1999)
The benefits to communities and individuals of screening for active tuberculosis disease: a systematic review [State of the art series. Case finding/screening. Number 2 in the series].
Kranzer K; Afnan-Holmes H; Tomlin K; Golub JE; Shapiro AE; Schaap A; Corbett EL; Lönnroth K; Glynn JR
2013
The international journal of tuberculosis and lung disease
Feasibility, Yield, and Cost of Active Tuberculosis Case Finding Linked to a Mobile HIV Service in Cape Town, South Africa: A Cross-sectional Study.
Kranzer K; Lawn SD; Meyer-Rath G; Vassall A; Raditlhalo E; Govindasamy D; van Schaik N; Wood R; Bekker LG
2012
PLoS medicine
Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review.
Kranzer K; Govindasamy D; Ford N; Johnston V; Lawn SD
2012
Journal of the International AIDS Society
Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysis.
Kranzer K; Houben RM; Glynn JR; Bekker LG; Wood R; Lawn SD
2010
The Lancet infectious diseases
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.
Walker TM; Merker M; Knoblauch AM; Helbling P; Schoch OD; van der Werf MJ; Kranzer K; Fiebig L; Kröger S; Haas W
The Lancet. Infectious diseases
Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study.
van Ingen J; Kohl TA; Kranzer K; Hasse B; Keller PM; Katarzyna Szafrańska A; Hillemann D; Chand M; Schreiber PW; Sommerstein R
The Lancet. Infectious diseases
Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment.
Polsfuss S; Hofmann-Thiel S; Merker M; Krieger D; Niemann S; Rüssmann H; Schönfeld N; Hoffmann H; Kranzer K
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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