My PhD, funded through a Wellcome Trust clinical tropical training fellowship, investigated the clinical epidemiology of adolescents with perinatally-acquired HIV. This was followed by two further Wellcome Trust Fellowships through which I investigated interventions to improve outcomes across the HIV care cascade (from HIV testing to linkage to care and achieving viral suppression) among children and young people, and on integration of HIV and sexual and reproductive and other health services. I currently lead a study that aims to develop and evaluate a multi-faceted biomedical pychosocial, nutritional care package for pregnant adolescents. I am also working on approaches to promote a shift away from syndromic to aetiological approaches for management of sexually transmittted infections (STIs) including STI screening in HIV and antenatal care services and in community-based settings.

My other area of research is multimorbidity across the life-course. I conduct clinical and pathogenesis studies on chronic comorbidities associated with HIV infection among children and adolescents, particularly respiratory, cardiac, musculoskeletal and neurocognitive disease. I lead an EDCTP-funded consortium (VITALITY: https://www.vitality-trial.co.uk) that is investigating high-dose vitamin D and calcium supplementation for improving musculoskeletal health of children with HIV.

I work on evaluation of multimorbidity prevention, screening and care packages for different population groups; I am the Zimbabwe lead for the FRACTURES E3 consortium (https://www.fractures-e3.com/) that is investigating the epidemiology, economic impact and ethnography of fragility fractures in Sub-Saharan Africa. I am a co-investigator on studies i) developing and evaluating "check-up" visits in adolescence to identify and manage common health problems combined with health promotion; and ii) a study developing and evaluating an intervention package to promote healthy ageing.