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Professor David Mabey

DM FRCP FMedSci

Professor
of Communicable Diseases

Room
Room 302

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 20 7927 2297

Fax.
+44 20 7927 2739

David Mabey is a physician specialising in Infectious and Tropical Diseases. After training in the UK, he went to work at the Medical Research Council unit in The Gambia, West Africa in 1978, and was in charge of clinical services there from 1982-86. He joined the School as a Senior Lecturer in the Department of Clinical Sciences in 1986, and was made Professor of Communicable Diseases in 1994. He is an Honorary Consultant Physician at the Hospital for Tropical Diseases in London. He was head of the Clinical Research Unit in the School from 1995-2002, and has been Director of the Wellcome Trust Bloomsbury Centre for Clinical Tropical Medicine/Global Health Research  http://www.lshtm.ac.uk/wbc/ since 1995. He was responsible for the Knowledge Programme on HIV/AIDS and Sexually Transmitted Infections, funded at the School by the Department for International Development http://www.lshtm.ac.uk/dfid/aids from 1991-2007. He is a member of the Scientific and Technical Advisory Group of the WHO Department of Reproductive Healh and Research, and was Director of the WHO Collaborating centre for the Prevention and Control of Sexually Transmitted Infections at the School from 2003-9.  He has been Chair of the Field Trials Committee of the STD Diagnostics Initiative at WHO/TDR since 2001. He is a member of the WHO Global Alliance for the elimination of trachoma, and has sat on the Trachoma Expert Committee of the International Trachoma Initiative. He was awarded the CBE in 2014 for services to health development in Africa and Asia.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Centres

International Diagnostics Centre
Malaria Centre

Teaching

David Mabey ran the DTM&H course at the School from 1988 to 1996. He set up the MSc course in Sexually Transmitted Diseases with colleagues at UCL, and started a study unit in the Control of Sexually Transmitted Infections (STIs) in 1996. He teaches on the London DTM&H course and the MScs in Control of Infectious Diseases and Tropical Medicine and International Health.  Since 2010 he has worked with Philip Gothard and colleagues at Makerere University, Kilimanjaro Christian Medical College, Johns Hopkins University and the University of Washington in Seattle to establish the School's new East African DTM&H course.

Research

 

David Mabey became interested in trachoma, caused by ocular infection with Chlamydia trachomatis, and in genital C. trachomatis infection, while working in the Gambia. Since the early 1980s he has continued to do research on both trachoma and sexually transmitted infections, with many collaborators both within and outside the School. Most of his field work has been done in The Gambia and Tanzania, and he also runs a laboratory at the School where he has worked on the pathogenesis of and immune response to C. trachomatis infection. He is particularly interested in the link between HIV infection and other STIs, and worked with Richard Hayes on the Mwanza intervention trial, which showed that it was possible to reduce the transmission of HIV by improved case management of other STIs at the primary health care level. With Robin Bailey,  Martin Holland and Matthew Burton, he has established one of the largest research groups in the world working on the pathogenesis, control and elimination of blinding trachoma. In recent years he has become particularly interested in the development and evaluation of new,  point-of-care diagnostics for infectious diseases, and worked with Rosanna Peeling to establish the International Diagnostics Centre at the School in 2012. Since 2012 he has been doing research on yaws in Papua New Guinea, Ghana and and the Solomon Islands, in support of the new WHO eradication programme.

Research Area
Bacteria
Clinical care
Clinical trials
Diagnostics
Innate immunity
Sexual health
Disease control
Impact evaluation
Implementation research
Discipline
Genetic epidemiology
Immunopathology
Bacteriology
Epidemiology
Immunology
Medicine
Microbiology
Opthalmology
Disease and Health Conditions
Syphilis
Eye diseases
HIV/AIDS
Infectious disease
Sexually transmitted disease
Trachoma
Blindness
Neglected Tropical Diseases (NTDs)
Sexually transmitted infection
Skin disease
Tropical diseases
Country
Brazil
China
Ethiopia
Ghana
Gambia, The
Guinea-Bissau
Hong Kong SAR, China
Malawi
Tanzania
Uganda
Zambia
Region
East Asia & Pacific (all income levels)
Latin America & Caribbean (developing only)
Sub-Saharan Africa (developing only)

Selected Publications

Posterior lamellar versus bilamellar tarsal rotation surgery for trachomatous trichiasis in Ethiopia: a randomised controlled trial.
Habtamu, E.; Wondie, T.; Aweke, S.; Tadesse, Z.; Zerihun, M.; Zewudie, Z.; Kello, A.B.; Roberts, C.H.; Emerson, P.M.; Bailey, R.L.; Mabey, D.C.; Rajak, S.N.; Callahan, K.; Weiss, H.A.; Burton, M.J.;
Lancet Glob Health
Mass treatment with single-dose azithromycin for yaws.
Mitjà, O. ; Houinei, W. ; Moses, P. ; Kapa, A. ; Paru, R. ; Hays, R. ; Lukehart, S. ; Godornes, C. ; Bieb, S.V. ; Grice, T. ; Siba, P. ; Mabey, D. ; Sanz, S. ; Alonso, P.L. ; Asiedu, K. ; Bassat, Q. ;
N Engl J Med
Serology for trachoma surveillance after cessation of mass drug administration.
Martin, D.L. ; Bid, R. ; Sandi, F. ; Goodhew, E.B. ; Massae, P.A. ; Lasway, A. ; Philippin, H. ; Makupa, W. ; Molina, S. ; Holland, M.J. ; Mabey, D.C. ; Drakeley, C. ; Lammie, P.J. ; Solomon, A.W. ;
PLoS Negl Trop Dis
Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study.
Roberts, C.H. ; Franklin, C.S. ; Makalo, P. ; Joof, H. ; Sarr, I. ; Mahdi, O.S. ; Sillah, A. ; Bah, M. ; Payne, F. ; Jeffreys, A.E. ; Bottomley, W. ; Natividad, A. ; Molina-Gonzalez, S. ; Burr, S.E. ; Preston, M. ; Kwiatkowski, D. ; Rockett, K.A. ; Clark, T.G. ; Burton, M.J. ; Mabey, D.C. ; Bailey, R. ; Barroso, I. ; Holland, M.J. ;
Sci Rep
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing.
Harris, S.R. ; Clarke, I.N. ; Seth-Smith, H.M. ; Solomon, A.W. ; Cutcliffe, L.T. ; Marsh, P. ; Skilton, R.J. ; Holland, M.J. ; Mabey, D. ; Peeling, R.W. ; Lewis, D.A. ; Spratt, B.G. ; Unemo, M. ; Persson, K. ; Bjartling, C. ; Brunham, R. ; de Vries, H.J. ; Morré, S.A. ; Speksnijder, A. ; Bébéar, C.M. ; Clerc, M. ; de Barbeyrac, B. ; Parkhill, J. ; Thomson, N.R. ;
Nat Genet
Point-of-Care Tests to Strengthen Health Systems and Save Newborn Lives: The Case of Syphilis.
Mabey, D.C. ; Sollis, K.A. ; Kelly, H.A. ; Benzaken, A.S. ; Bitarakwate, E. ; Changalucha, J. ; Chen, X.S. ; Yin, Y.P. ; Garcia, P.J. ; Strasser, S. ; Chintu, N. ; Pang, T. ; Terris-Prestholt, F. ; Sweeney, S. ; Peeling, R.W. ;
PLoS Med
Point-of-care tests for diagnosing infections in the developing world.
Peeling, R.W.; Mabey, D.;
Clin Microbiol Infect
See all Professor David Mabey's Publications