The Department of Infection Biology (IBD) brings together pathogen molecular biology and immunology research across LSHTM.
Aspects of infection biology of interest include:
- determining the molecular mechanisms of infection of globally important pathogens
- deciphering the genetic diversity of selected disease agents in natural populations and determining its immunological and epidemiological impact
- understanding how innate and adaptive immune responses are generated against these pathogens and how they avoid immune defences
- exploiting parasitic, bacterial and viral pathogens as model biological systems
- developing practical applications including improved diagnostic tests and the identification and characterisation of vaccine candidates and drug targets
Research focuses on three main groups of pathogens:
- bacteria (Acinetobacter baumannii, Actinobacillus pleuropneumoniae, Burkholderia pseudomallei, Campylobacter jejuni, Clostridium difficile, Francisella tularensis, Helicobacter pylori, Haemphilus parasuis, Mycobacterium leprae, Mycoplasma hyopneumoniae, Mycobacterium tuberculosis, Staphylococcus aureus, Streptococcus suis, Streptococcus pneumonia, Yersinia enterocolitica, Yersinia pseudotuberculosis)
- parasites (Entamoeba histolytica, Leishmania donovani, Plasmodium falciparum, Plasmodium knowlesi, Plasmodium vivax, Plasmodium berghei, Trypanosoma brucei, Trypanosoma cruzi)
- viruses (African horse sickness, bluetongue, dengue, epizootic haemorrhagic disease, human herpesvirus 6, human cytomegalovirus, influenza, SARS)
Publications by department staff can be viewed in the School’s online repository.