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A Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls (DoRIS)

A Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls (DoRIS) trial evaluates immunogenicity and safety of one dose of HPV vaccine in Tanzania. The objective of this trial is to demonstrate non-inferiority of immune responses with 1 dose of HPV vaccine compared with the recommended 2 or 3 doses of the same vaccine by evaluating HPV 16/18-specific seropositivity, antibody avidity and memory B cell responses at M36. 

Evaluating the impact of Pneumococcal Conjugate Vaccine (PCV10) in Kenya

The Pneumococcal Conjugate Vaccine Impact Study (PCVIS) is one of the first population-level studies to look at the impact of a pneumococcal conjugate vaccine (PCV10) programme on childhood pneumonia and pneumococcal disease protection in a low- or middle-income country. It is a partnership between the KEMRI-Wellcome Trust Research Programme, the London School of Hygiene & Tropical Medicine, GAVI and the Government of Kenya.

Ebovac

Ebola vaccine projects – EBOVAC1EBOVAC2EBOVAC3EBODAC and EBOMAN – are a series of trials and associated projects which aim to assess a novel two-dose preventive vaccine regimen against Ebola Virus Disease (EVD). In a two-dose vaccine regimen, individuals are given a first dose to prime the immune system, and then a second dose which is intended to enhance the immune response and increase the duration of the response.

Ebola

SYSVAC

SYSVAC is a database of systematic reviews on vaccines and immunisation. These have been collated from other databases, so as to provide a more streamlined resource.