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Ebola in West Africa. Credit: European Commission DG ECHO

UK Public Health Rapid Support Team (UK-PHRST)

A specialist team ready to respond to disease outbreaks around the world before they develop into health emergencies. The team also conducts rigorous operational research to improve epidemic preparedness.

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About

The UK-PHRST, funded by UK aid from the Department of Health and Social Care, supports low- and middle-income countries in investigating and responding to disease outbreaks and conducts research to improve our response to future epidemics.

Who we are

The UK-PHRST is a partnership between the London School of Hygiene & Tropical Medicine and the UK Health Security Agency, with contributing academic partners.

About
About UK-PHRST 2 columns
About UK-PHRST
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About the team

Through the UK Public Health Rapid Support Team (UK-PHRST), the UK has the capacity to respond rapidly to disease outbreaks in low- and middle-income countries around the world and conduct operational research into epidemic preparedness, playing an important role in global health security. The team also works to help countries to build their own capacity for an improved and rapid national response to outbreaks.

The UK-PHRST is funded by UK aid from the Department of Health and Social Care and is a partnership between the London School of Hygiene & Tropical Medicine (LSHTM) and the UK Health Security Agency (UKHSA) with contributing academic partners.

Tackling disease outbreaks at their source at the earliest possible stage helps prevent their spread, saves lives, and is the most effective way to protect the UK. As of March 2021, the team has taken part in just over 20 deployments across more than 10 countries.

Deployable team

UK-PHRST member in personal protective equipment. Credit: UK-PHRST
UK-PHRST member in personal protective equipment. Credit: UK-PHRST

The UK-PHRST comprises of a core team of experts ready to deploy overseas within 48 hours to support countries in responding to disease outbreaks.

The deployable team includes experts in tracking the progress of an outbreak (epidemiologists); in diagnosing the cause of an outbreak (microbiologists); in advising on outbreak control measures (infection prevention and control) and community responses to outbreaks (social scientists); and in developing the best clinical response measures (clinical researchers). The full team comprises:

  • Epidemiologists
  • Clinical researcher
  • Social scientist
  • Microbiologists
  • Data scientist
  • Infection prevention and control expert
  • Logistician

Deployment of the UK-PHRST is at the invitation of the host government or in response to requests made by the World Health Organization (WHO) or by the Global Outbreak Alert and Response Network  (GOARN).

Reservist team

In addition to the deployable team, the UK-PHRST will train a group of public health reservists to ensure the UK is able to scale up its response to any disease outbreak or health emergency. Information on how to join the public health reserve cadre will be posted as soon as it is available.

Case study: UK-PHRST action against Lassa fever

Lassa virus causes a potentially fatal haemorrhagic fever syndrome that, in its most severe form, is similar to Ebola virus disease. The virus is carried by a rodent called the “multimammate rat”, which is found across West Africa, infecting humans exposed to infected rodent excreta, with occasional secondary transmission between humans, including to healthcare workers. There are estimated to be hundreds of thousands of infections and tens of thousands of deaths due to Lassa fever every year, with transmission usually peaking during the dry season.

Outbreak response: Putting out the fire

Lassa fever reached epidemic proportions in Nigeria during the dry seasons of 2018 and 2019, prompting the Nigerian Centres for Disease Control to request support from the UK-PHRST. The UK-PHRST quickly deployed personnel to provide epidemiologic, laboratory, and logistical support to Nigeria to help bring the outbreak under control.

Research: Identify the causes of the fire

The UK-PHRST is collaborating with investigators in Nigeria and Sierra Leone – two countries where Lassa fever is hyperendemic and often leads to epidemic spread – to fill key knowledge gaps regarding this dangerous disease. These include studies exploring the clinical evolution and pathogenesis of Lassa fever and looking at the pharmacokinetics of ribavirin, a drug used to treat the disease but whose efficacy and mechanism of action remains to be determined.

In the laboratory, the UK-PHRST is working on the development of a less invasive diagnostic antibody test that can be performed on saliva (as opposed to on blood), which will facilitate field studies on risk factors for transmission. The UK-PHRST is also engaged in social science research to better understand healthcare seeking behaviour for febrile illness in an effort to encourage early recognition and presentation of care for people with Lassa fever, potentially allowing rapid implementation of life-saving care.

Capacity building: Preventing future fires

With an eye to the long-term, the UK-PHRST is helping to development clinical research capacity at the Kenema Lassa Ward in Kenema, Sierra Leone, one of the major care centres for the disease in West Africa. This will facilitate the study of novel therapeutic agents and vaccines for Lassa Fever, with the hope of ultimately being able to prevent the disease. In addition to enhancing the physical infrastructure in Kenema, the UK-PHRST has sponsored the training of local physicians in the use of various techniques, such as echocardiography to assess cardiac function, to better understand the pathophysiology of Lassa fever, and thus provide better clinical care.

Background to the UK-PHRST

Former Public Health Minister, Nicola Blackwood meets Martin Hibberd and Sonal Shah on a visit to LSHTM to launch the UK-PHRST in 2016. Credit: London School of Hygiene & Tropical Medicine/ Anne Koerber
Former Public Health Minister, Nicola Blackwood meets Martin Hibberd and Sonal Shah on a visit to LSHTM to launch the UK-PHRST

The Ebola crisis in West Africa in 2014/15 highlighted the need for the international community to develop a system to help countries respond to and control disease outbreaks that pose a threat to public health, before they develop into a global emergency.

The UK Public Health Rapid Support Team was developed as part of the UK contribution to global health security and to complement the World Health Organization’s work on the Global Health Emergency Workforce. The team is funded over five years by £20 million made available from the UK official development assistance budget. Former Public Health Minister Nicola Blackwood officially announced the launch of the team in November 2016.

The London School of Hygiene & Tropical Medicine was chosen to lead the UK-PHRST in partnership with Public Health England. LSHTM is a world authority in public and global health research. During the Ebola crisis, LSHTM staff advised governments, analysed data to assist in response planning, conducted clinical trials of vaccines and treatments, provided a free online course for healthcare professionals, developed culturally sensitive interventions to change behaviour in local communities, volunteered on the frontline in Ebola treatment centres, and carried out research to strengthen the global response to future infectious disease epidemics. LSHTM was also involved in the response to the Zika virus outbreak and ongoing related research.

Further information:

Who we are

The UK Public Health Rapid Support Team is jointly run by the London School of Hygiene & Tropical Medicine and the UK Health Security Agency, with contributing academic partners.

Team Block
UK-PHRST Director
Ben Gannon head shot

Ben Gannon

UK-PHRST Director (LSHTM / UKHSA)
UK-PHRST Director (LSHTM / UKHSA)
UK-PHRST Deputy Directors
Ashley Sharp

Ashley Sharp

UK-PHRST DEPUTY DIRECTOR FOR OPERATIONS (UKHSA)
Gwenda Hughes headshot

Gwenda Hughes

Deputy Director of Research
Deputy Director for Research LSHTM
UK-PHRST Core Deployable Team

Hilary
Bower

Assistant Professor
Epidemiologist (LSHTM)
Ben Gannon head shot

Ben Gannon

UK-PHRST Director (LSHTM / UKHSA)

Emilio Hornsey

Infection control nurse (PHE)

Hana
Rohan

Assistant Professor
Social scientist (LSHTM)

David
Kennedy

Research Fellow
Research Fellow in Data Science
UK-PHRST Programme Management Team

Thom Banks

UK-PHRST Programme Manager (LSHTM)

Susan Ismaeel

UK-PHRST Programme Manager (UKHSA)

Katie Carmichael

UK-PHRST Operations and Deployments Manager (UKHSA)

Rosanna Glazik

UK-PHRST Project Coordinator - Knowledge Development (LSHTM)

William Nicholas

UK-PHRST Project Coordinator (LSHTM)

Kate Jones

UK-PHRST Project Administrator (LSHTM)
UK-PHRST Training Team

Arlinda
Cerga-Pashoja

Assistant Professor
Training Lead (LSHTM)

Training Co-ordinator (PHE)
UK-PHRST Technical Steering Committee

Hilary
Bower

Assistant Professor
Chair, Interim Deputy Director for Research, UK-PHRST

Daniel
Bausch

Professor
UK-PHRST Director (LSHTM / UKHSA)
Ashley Sharp

Ashley Sharp

UK-PHRST DEPUTY DIRECTOR FOR OPERATIONS (UKHSA)

Richard Amlôt

Scientific Programme Leader, Behavioural Science / (UKHSA)

Miles Carroll

Head of Research at Health Protection Agency / (UKHSA)

John
Edmunds

Professor
(LSHTM)

Judith
Glynn

Professor
(LSHTM)

Professor Ian Goodfellow

Professor of Virology ( Cambridge University)

Martin Hibberd

Professor / (LSHTM)

Peter Horby

Professor of Emerging Infectious Diseases and Global Health / (Oxford University)

Shelley
Lees

Professor
(LSHTM)

Rosanna Peeling

Professor of Diagnostics Research / (LSHTM)

James Rubin

Assistant Director of The Department of Psychological Medicine / (KCL)

Ian Walker

Consultant in Global Public Health / (UKHSA)

Chinwe Lucia Ochu

Director, Prevention, Programmes & Knowledge Management Nigeria Centre for Disease Control
Deployments
UK Public Health Rapid Support Team (UK-PHRST) Deployments 2 columns
UK Public Health Rapid Support Team (UK-PHRST) Deployments
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Mudslide in Sierra Leone. Credit: UNICEF
Mudslide in Sierra Leone. Credit: UNICEF

The UK Public Health Rapid Support Team (UK-PHRST) receives requests for deployment through WHO-GOARN, direct requests from the government of the state affected by the epidemic, or through the UK Emergency Medical Team and DFID.

The first deployment of the UK-PHRST took place in April-May 2017, when two epidemiologists and one clinical researcher deployed through GOARN to the Somali Regional State of Ethiopia to support an escalating outbreak of acute watery diarrhoea.

This was followed in May-June 2017 by a deployment through GOARN to Nigeria when a team of two epidemiologists and one laboratory microbiologist assisted in the response to an outbreak of cerebral meningitis.

The UK-PHRST’s first bilateral deployment was to Sierra Leone (August-September 2017) when two epidemiologists, two microbiologists, one logistician, two Field Epidemiology Training Programme (FETP) fellows and the UK-PHRST Director were deployed. In this instance they assisted in the establishment of water-borne disease surveillance and assessment of diagnostic capacity at Connaught Hospital in Freetown in the wake of heavy rains, flooding and landslides in and around the capital.

In October – November 2017, two epidemiologists and one clinician were deployed to Madagascar though GOARN to support the response to an outbreak of pneumonic plague affecting primarily two large urban centres.

This was followed by a deployment to Bangladesh (December - January 2017/18) when a team consisting of an epidemiologist, a FETP fellow and an Infection Prevention Control (IPC) specialist worked alongside the UK Emergency Medical Team and DFID in support of the international response to the outbreak of diphtheria in the displaced Rohingya population in refugee camps in Cox’s Bazar.

The second bilateral deployment came in February-March 2018 in Nigeria, when an epidemiologist, FETP fellow, case management specialist and a logistician supported the government in controlling a large outbreak of Lassa fever through field-level interventions, logistics, capital-level data analysis and intervention strategy. This fostered a good partnership between UK-PHRST and Nigeria Centre of Disease Control (NCDC). In February-March 2019, UK-PHRST were invited to support the control of the a Lassa fever outbreak in Nigeria once more. 

During February – March 2018, two epidemiologists and one infection prevention and control specialist were deployed to Bangladesh once again to support the WHO response to surveillance and monitoring of infectious disease outbreaks in the Rohingya refugee camps in Cox’s Bazar. In July 2018 an IPC specialist was redeployed to Cox’s Bazar.

In May-June 2018 during the Ebola outbreak in DRC, UK-PHRST deployed two epidemiologists and a data scientist to support with strengthening the alert system, including case investigation, protocol development, epidemiological analysis and data management.

The UK-PHRST is still actively engaged in the ongoing Ebola outbreak in DRC and has been instrumental in providing senior epidemiological support and in setting up the analytical cell, which is fully operational at the strategic coordination level (currently in Goma). 

In 2019, deployments of UK-PHRST epidemiologists, data scientists and IPC specialist in response to the Ebola outbreak in DRC, have been continuous through GOARN.

At the end of March 2020, UK-PHRST in-person deployments to Africa CDC (Ethiopia), WHO Western Pacific Regional Office (the Philippines) and WHO Nepal to support the response to the emerging COVID-19 outbreak were cut short. This was due to the abrupt cessation of flights and rapid closure of borders globally. Despite the rapid change in location, the teams quickly adapted to remote working, continuing the support they had initiated with colleagues overseas. 

This coordinated package of remote support has continued alongside in-person deployments when possible, subsequently benefiting from the team’s ability to draw on additional expertise from the pool of reservists and extended team when required.

Summary of Key COVID-19 Response Activities 

Africa CDC

Initially an epidemiologist, infection prevention and control (IPC) specialist, social scientist and microbiologist were engaged directly at the Africa Centres for Disease Control and Prevention (Africa CDC) headquarters in Ethiopia. Since their return to the UK, a comprehensive programme of remote support has continued. Key areas include:

  • Epidemiology
  • Infection prevention and control
  • Laboratory
  • Social science

Read more: UK Public Health Rapid Support Team COVID-19 Response – Africa Centres for Disease Control and Prevention

Bangladesh

We continue to build on previous UK-PHRST deployments as well as remote support to WHO’s Sub Office in Cox’s Bazar, with support from Field Epidemiology Training Programme (FETP) Fellows and UK-PHRST reservists. Key areas include:

Read more: UK Public Health Rapid Support Team COVID-19 Response – Bangladesh

WHO African Regional Office

One UK-PHRST field epidemiologist and two data scientists assisted WHO AFRO with analysis and interpretation of data gathered from across member states. The team supported WHO AFRO remotely and provided brief reports on the data that different countries had provided.

WHO Country Office (WCO) Tajikistan

In June, the UK-PHRST deployed one microbiologist and one epidemiologist on an assessment mission to determine the appropriateness, feasibility and likely impact of deployment of a Rapid Response Mobile Laboratory (RRML) to support the COVID-19 response. This was in response to a request for support through the Global Outbreak Alert and Response Network for the Tajikistan Ministry of Health and Social Protection in response to increasing case numbers of COVID-19.

The Gambia

Following a joint rapid assessment on COVID-19 response with colleagues from Africa CDC, UK-PHRST deployed a team of four to support the scaling up of testing and contact tracing services and the improvement of data systems. This was a bilateral deployment in collaboration with the Ministry of Health with support from two epidemiology specialists and two laboratory experts, all of whom have now returned to the UK and will continue to engage remotely.

Read more: COVID-19 Surveillance in The Gambia 

Strengthening public mental health in Africa in response to COVID-19

Globally, mental health faces unprecedented challenges due to COVID-19.  Bereavement, isolation, loss of income and fear are triggering mental health conditions or exacerbating existing ones.  National leaders face significant challenges in protecting and scaling up mental health support as part of the COVID-19 response. A recent WHO global survey indicated that 37% countries reported that COVID-19 mental health response plans were only partially funded and a further 37% reported having no funds at all.

The UK-PHRST “Strengthening public mental health in Africa in response to COVID-19” project, due for completion in March 2021, aims to better understand enablers and barriers to integrating mental health and psychosocial support (MHPSS). 

Read more: UK-PHRST Strengthening public mental health in Africa in response to COVID-19

Research
Research UK Public Health Rapid Support Team (UK-PHRST) 2 columns
Research UK Public Health Rapid Support Team (UK-PHRST)
Paragraph
Wall with Ebola messages in Freetown, Sierra Leone, 2014. Credit: Jimmy Whitworth
Wall with Ebola messages in Freetown, Sierra Leone, 2014. Credit: Jimmy Whitworth

When not responding to disease outbreaks, the UK Public Health Rapid Support Team (UK-PHRST) conducts rigorous operational research to improve epidemic preparedness and enhance our understanding of how best to tackle these threats in the future.

The team’s work will help generate an evidence base for best practice in disease outbreak interventions.

The London School of Hygiene & Tropical Medicine (LSHTM) leads an academic consortium which includes University of Oxford, King's College London and University of Glasgow, to carry out this research.

LSHTM

At LSHTM there are academics from a range of disciplines who are involved in research related to the UK-PHRST. Their areas of expertise include epidemiology, mathematical modelling, anthropology, community engagement and trust, virology, bacteriology, mental health and clinical research.

Projects include:

Epidemic Response Anthropology Platform

The UK-PHRST funds the Epidemic Response Anthropology Platform, which is a partnership between LSHTM and the Institute of Development Studies. The platform is a resource to support a humane and effective response to epidemics. It aims to promote evidence on the social dimensions of epidemics in different contexts and to improve the way this evidence is used in response planning. The platform builds networks of anthropologists and other social scientists with regional or subject expertise and connects them to policy makers, scientists and humanitarian response workers involved in responding to outbreaks.

The contribution of social science research to outbreak response

This work was led by Shelley Lees and Karl Blanchett (LSHTM). The project had two components:

  • Component one consisted of exploring the views and experiences of anthropologists and other social scientists, and key information from organisations involved in infectious disease responses on the role of social scientists.
  • Component two consisted of conducting secondary data analysis of research concerning community views and experiences of the Ebola response during the 2014 to 2016 Ebola epidemic.

An oral presentation was delivered at the Quebec Outbreak Intervention Symposium 2017, with Shelley Lees being invited as a main speaker. Manuscripts describing the work are being finalised.

This project has raised the profile of the UK-PHRST within the social science community. A social science working group has been formed at LSHTM to support the research team, which will be sustained. The findings of this work helped define the profile of the social researcher to be recruited into the UK-PHRST and have also guided the social science working group when developing the social science research strategy. On a wider scale, these findings will inform contemporary debates about the role of social scientists and anthropologists in outbreaks, and on how to engage with affected communities.

Effect of acute illness on contact patterns, Malawi

This work was led by Judith Glynn (LSHTM). Understanding population mixing patterns are vital for predicting how infectious diseases move through communities. This project aimed to assess how acute illness affects contact patterns in a rural African setting in northern Malawi. We recorded contacts over 48-hours following a clinic consultation for acute illness and again 2-3 weeks later for the recovered person and for their mother/carer, if a child.

We documented changes in contact patterns when ill and these findings will help to refine models of infection transmission, which are essential for understanding how infections spread, and for planning appropriate interventions. We are preparing a paper for publication.

Study of the aetiology of severe undifferentiated febrile illness outbreaks in Sudan

This work was led by Hilary Bower (LSHTM), Tom Fletcher (Liverpool School of Tropical Medicine), and Mubarak Mustafa El Karsany (Karary University/Federal Ministry of Health (FMoH)).

The research aims to assist the FMoH of Sudan to identify the causative agent(s) of outbreaks of febrile illness associated with haemorrhagic symptoms that occur regularly in the country and to inform public health intervention and diagnostic capacity for them.

The study involves testing legacy samples from an outbreak in Dafur in 2015/16 (~500 case; 18% case fatality) at PHE Porton Down, and developing a prospective study with a FMoH and Karary University team to encourage more rapid identification and better description of the disease in future outbreaks.

To date, a set of stored outbreak samples have been prepared and transferred, with the collaboration of colleagues from the National Public Health Laboratory (NPHL) and FMoH agreement, to PHE Porton Down and tested on a bespoke panel of molecular and serological assays covering a broad range of likely pathogens. Results have been shared with the Ministry and will be published shortly. A prospective study protocol has been developed with ethical approval from LSHTM, Karary University and the FMoH Technical Review Board, and a seven-person team has been trained in study implementation, with basic logistics also in place for a rapid start if/when an outbreak occurs. If no outbreak of the syndrome occurs within the current grant period, the protocol will remain in place ready to be triggered by Sudanese colleagues and we anticipate a request for UK-PHRST support may be made at that time.

Our project has created a new and strong collaboration with the FMoH and the NPHL, and provided a good example of UK research collaboration and support to improve outbreak investigation and control in Sudan. As health scientists in Sudan emerge from the period of sanctions, we hope these relationships with key outbreak-related departments of the FMoH will create further opportunities to assist outbreak response and International Health Regulation capacities in the country.

Establishing real-time evaluations of WASH on disease outbreaks in emergency settings

This work was led by Oliver Cumming and Lauren D’Mello-Guyett (LSHTM). The project aimed to combine the academic experience of LSHTM and the operational experience of Médecins Sans Frontières (MSF) to strengthen the evidence base for Water, Sanitation and Hygiene (WASH) interventions used in disease outbreaks in emergency settings in low and middle-income countries (LMICs).

The role of WASH interventions as a means to both preventing and controlling infectious disease outbreaks is well established. However, at a practice and policy level, there have been calls to address the evidence gap as to how WASH interventions can be best mobilized to support during outbreak responses. We therefore developed approaches for evaluating the WASH component of MSF outbreak responses with a particular focus on study designs and methods that are appropriate for cholera outbreaks during complex emergencies.

Using these approaches to more rigorously evaluate WASH interventions will help strengthen the effectiveness of routinely delivered interventions for cholera control and improve access and outcome among vulnerable populations in low income settings.

Three summary reports are available from our field site visits to MSF projects in Nigeria and South Sudan, evaluating the ability, risks, and ethical considerations to be able to conduct operational research in such a setting. These are supplemented by a desk-based study including interviews with MSF staff in Central African Republic and Democratic Republic of Congo (DRC).

Three “sleeper protocols” that could be adapted for urban or rural contexts and/or closed or open settings within DRC have been developed. Ethical approval has been granted on the basis that an update will be submitted when an appropriate study site has been identified at the start of a conducive cholera outbreak. The collaboration has continued with MSF with plans to implement the protocols in DRC during the next cholera outbreak. Copies of the reports and protocols can be obtained on request from oliver.cumming@lshtm.ac.uk.

Building readiness for real-time pathogen sequencing for surveillance and control of infectious disease outbreaks

This work was performed by teams from PHE and LSHTM. The aim of the study was to take advantage of new technologies for near-real time genome sequencing in the field. We aimed to develop specific genome sequencing primers for selected viruses capable of causing outbreaks, validate sequencing methods and primers using UK returning traveller clinical samples and evaluate MinION sequences in relation to MiSeq,

Equipment is now in place within UK PHRST for amplicon-based viral whole-genome-sequencing on the MinION, primer sets have been designed and provisioned for 4 dengue virus serotypes, 3 chikungunya lineages, and 5 Lassa virus lineages. The UK PHRST lead microbiologist has been trained in the use of the MinION and the primer sets, a bioinformatic pathway has been developed in-house at LSHTM. Testing shows DENV-1,2,3 and CHIKV Asia and ECSA schemes are fully effective at detecting viruses with good genome coverage.

However, the schemes were less effective for DENV-4, CHIKV West Africa and Lassa; most likely due to lack of a relevant reference genome and future work could be done to establish this. A strategy for amplicon-based Crimean Congo Haemorrhagic Fever (CCHF) virus genome sequencing has also been developed by PHE using a separate funding source. The primers and protocol are also available to the UK PHRST. All established protocols could now be field tested for further integration into the PHRST.

We aim to transfer technology to laboratories in West Africa and evaluate performance in an LMIC setting, and utilize sequence clustering and other bioinformatics tools to determine the performance of sequence results in identifying transmission.

University of Glasgow

The MRC-University of Glasgow Centre for Virus Research (CVR) is home to an internationally leading critical mass of virologists, entirely focused on the study of human viral diseases and viruses at the human-animal interface. Established in 2010 as a partnership between the University and the Medical Research Council (MRC), the CVR contributes to national virology capability and supports the global response to viruses and the diseases they cause. 

Collaborative supervision of a healthcare worker study in Uganda

Kasese District is nestled in the far western corner of Uganda, surrounded by mountainous national parks, and bordering the Democratic Republic of Congo (DRC). Building on existing collaborations with Kagando hospital, a team from the MRC-University of Glasgow Centre for Virus Research (CVR) is investigating the prevalence of exposure to viral hemorrhagic fever viruses (VHF viruses) and SARS-CoV-2 in health care workers and surrounding communities. VHF viruses are regularly seen in this part of Uganda and cause a variety of diseases: Rift Valley Fever (RVF), Ebola and Crimean congo haemorrhagic fever (CCHF). This study seeks to understand the epidemiological spread of disease in healthcare workers and abattoir workers in order to strengthen prevention strategies.

Pandemic roadblock

After successfully running several studies in Uganda, international travel was suspended and team members from the UK were unable to visit the research sites. However, with the leadership of Dr Mary Munyagwa, medical director at Kagando hospital and Stella Atim, a veterinarian and PhD fellow at Makerere University who is investigating CCHF in Uganda and remote assistance from members of the CVR team, the study went ahead. Laheri Kabugho was appointed as team leader with Mercy Musoki, Joshua Muhindo, Esther Atolere and Mercy Kabugho as study nurses, Bettress Happy and Robinah Aliganyira as HIV counselor, Robert Muhindo as community mobilizer and Edson Masereka as laboratory technologist. Alongside the need to train staff in sample collection and research, the UK team also ensured that equipment was delivered in a timely and safe manner – with items such as blood tubes and needles, a heat block, and the relevant trial documentation i.e. consent forms.  

What did they do about it?

Zoom provided the platform to carry out remote training with powerpoint slides and videos shared online. WhatsApp daily communication was also an essential tool.

(L-R): Mercy, Bettress, Laheri and Joshua in Kagando, with Marina on Zoom.
(L-R): Mercy, Bettress, Laheri and Joshua in Kagando, with Marina on Zoom.

 

Marina Kugler, Project Coordinator, made sure that the equipment and necessary items for the study arrived, carefully boxed and labelled from Glasgow.

‘We organised kits and lab equipment, printed out consent forms and packed boxes with needles, phones, face masks and much more. Everything was labelled so the participants could be easily recruited and to reduce administrative errors in the very important documentation of the study’.

The minutiae required in planning a remote study was not underestimated and enabled the successful implementation of the research. Participants were recruited at a rate of ~30 per day, blood samples were heat inactivated and stored in the delivered freezer, before transported to Entebbe for testing at the UVRI.

Blood samples for transportation
Blood samples for transportation

Study questionnaires were filled out via mobile phones and REDCap, rather than by paper, to allow quick collection and safe storage. Data is available in real time online, which allowed Marina to check for missing values and any queries were resolved on Whatsapp – the fastest and most reliable way to communicate with the study site. Laheri and the team also commented on the ease they felt in getting help and support from the remote team.

‘The care and the support you gave us was the best part of the study. It was not as we were alone, we were always with you during the whole study.’ - Laheri

One of the key elements of any study is the mobilisation of communities and this was carried out very effectively by the study team. Stella, Laheri and Robert would meet with a member of the village health team and the village leader to explain the study. Through these contacts, they would organise mobilisation in the villages to recruit participants.

What can we learn?

Clear expectation setting with stakeholders is important, especially in regard to the availability of data for analysis. Depth is paramount with many qualitative or mixed-methodological studies, and when timing is disrupted, staying open, positive, and accommodating goes a long way toward ensuring high-quality data. It’s advisable to build in padding for each and every stage of the research process, from recruitment through to analysis. Staying flexible will help ensure maximum number of participants are recruited and it will also reinforce a collaborative research ethos, which is important now more than ever.

What is next?

Right now, the team is working on the data analysis of all 300 health care workers with their sex/age/geographically matched 450 community members. The results will provide information about the epidemiological spread of viral infections in the expected special risk group of health care workers. Results will be communicated to the study groups and solutions for risk reduction will be developed together.


 

University of Oxford

The Epidemic Diseases Research Group Oxford (ERGO) delivers on the clinical operational research theme and contributes to the core deployable team and the training and capacity building in low and middle income countries. ERGO is led by Professor Peter Horby and the group aims to reduce the health and socioeconomic impact of emerging and epidemic infections by conducting and enabling clinical research in this area.

Since the launch of the UK-PHRST, members of the Oxford team have worked in Ethiopia, Nigeria, Madagascar, Sierra Leone, Nigeria and Cambodia, either as part of deployments or on research projects with local staff.

Selected research projects completed by ERGO:

Rapid needs appraisal to inform clinical research priorities in response to (re-) emerging outbreaks

This work was led by Louise Sigfrid together with Alex Salam, Catrin Moore and Peter Horby.

The evidence base for the response to epidemics of (re-)emerging pathogens is limited. Research is rarely an early priority, there are many challenges at the outset of an epidemic, and there is a limited window of opportunity to implement research.

This means it is important that the priorities for research are rapidly, but rigorously defined during the earliest stages of an epidemic, while considering ethical aspects and ensuring the potential for a direct clinical and public health impact.

A methodology for rapidly (≤5 days), systematically and transparently identifying key knowledge gaps to inform research priorities during emergency outbreaks was developed in collaboration with Evidence-Aid and Cochrane response.

The intention is that the outcome from the rapid research needs appraisal will be used to inform clinical research prioritisations.

The methodology was piloted in July 2017 using a Lassa fever outbreak scenario and the results compared with expert opinions collected from Lassa fever experts to inform the final version of the protocol.

The methodology was presented at the Global Evidence Summit in South Africa in September 2017.

Patient data quality improvement in epidemics: An audit of West African Ebola data

This work was led by Amanda Rojek, Alex Salam, Peter Horby and the Infectious Diseases Data Observator.

Good medical record keeping is a challenge, particularly in humanitarian public health emergencies, and this is likely to impact clinical care for patients.

The overall aim of this project was to evaluate the quality of clinical data from patient records from the West African Ebola outbreak (2014/15).

The project was divided into 3 sub-projects:

  • A systematic review and metaanalysis of published clinical data from the West African Ebola outbreak
  • A questionnaire for healthcare workers, investigating their perceptions of the quality of clinical record keeping whilst working in West African Ebola Treatment Centres
  • An audit of clinical data from 5,000 Ebola virus disease clinical case records from West Africa

This project will help generate an evidence base for best practice for medical record keeping in disease outbreaks and humanitarian emergencies in developing countries.

An evaluation of syndromic surveillance and clinical characterisation of EEID syndromes in refugee camps

This work was led by Amanda Rojek together with Karl Blanchet (LSHTM) and Peter Horby.

There is an unprecedented global forced migration, with the UN Refugee Agency (UNHCR) estimating that more than 65 million people are in need of protection. At least 12 million of these are living in refugee camps, which are a high risk environment for disease outbreaks.

This work aimed to improve the provision of accurate and comprehensive clinical information that verifies an outbreak, characterises the likely cause and severity of illness, and identifies populations at risk.

The team collected prospective data from thirteen refugee camps across Greece, where research nurses observed clinical consultations with recently arrived refugees presenting with syndromes consistent with outbreak prone infectious diseases.

The data were collected to find out the extent to which the risks for infection, severity of infection and clinical manifestations of infection were assessed and recorded.

The study findings were published in BMC Medicine.

ERGO have several research projects currently underway. These include: Rapid identification and characterisation of avian influenza viruses by direct Nanopore sequencing in collaboration with Institut Pasteur du Cambodge; an ongoing cohort study looking at clinical characterisation and microbiological diagnosis of patients with suspected pneumonic plague in collaboration with Institut Pasteur de Madagascar; and Lassa fever cohort study based in Sierra Leone and Nigeria in collaboration with Kenema Government Hospital and Owo Federal Medical centre respectively. 

In collaboration with the WHO/Tropical Diseases Research (TDR) programme, ERGO developed and ran a training curriculum on generating clinical evidence during outbreaks in lower and middle income countries (the Clinical Research During Outbreaks Course - CREDO). The delivery of the curriculum will build capacity overseas for an improved and rapid national research response to disease outbreaks. CREDO received accreditation for the African Academy of Sciences in 2017. The work was presented in October 2017 as a poster at the 10th European Congress on Tropical Medicine and International Health, Antwerp, Belgium.

King’s College London

Research into the mental health aspects of infectious disease outbreaks is led by a joint team from the NIHR Health Protection Research Unit in Emergency Preparedness and Response at King’s College London and the South London and Maudsley NHS Foundation Trust.

Projects already completed by the team as part of their UK-PHRST work include studies to understand the feasibility and effectiveness of small group therapy for staff in Sierra Leone who worked in Ebola treatment centres, the preliminary results of which are available in the International Journal of Social Psychiatry.

Ongoing work involves assessing whether it is possible to ‘screen’ people who wish to work on future infectious disease outbreaks, to identify and support people at risk of experiencing distress as a result of this work. For further information, please contact Dr James Rubin at KCL.

Publications
Scientific Papers
‘Learn from the lessons and don’t forget them’: identifying transferable lessons for COVID-19 from meningitis A, yellow fever and Ebola virus disease vaccination campaigns
Julie Collins, Rosie Westerveld, Kate A Nelson, Hana Rohan, Hilary Bower, Siobhan Lazenby, Gloria Ikilezi, Rebecca Bartlein, Daniel G Bausch, David S Kennedy
2021
BMJ Global Health
“Kankasha” in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan
HILARY BOWER, Mubarak el Karsany, Abd Alhadi Adam Hussein Adam, Mubarak Ibrahim Idriss, Ma’aaza Abasher Alzain, Mohamed Elamin Ahmed Alfakiyousif, Rehab Mohamed, Iman Mahmoud, Omer Albadri, Suha Abdulaziz Alnour Mahmoud, Orwa Ibrahim Abdalla, Mawahib Eldigail, Nuha Elagib, Ulrika Arnold et al. |
2021
PLOS Neglected Tropical Diseases
Lay-delivered talk therapies for adults affected by humanitarian crises in low- and middle-income countries
Grace K. Ryan, Andreas Bauer, Tarik Endale, Onaiza Qureshi, Asmae Doukani, ARLINDA CERGA-PASHOJA, Savvy K. Brar, Julian Eaton & Judith K. Bass
2021
BMC Conflict & Health
80 questions for UK biological security
Kemp L, Aldridge DC, Booy O, Bower H, Browne D, et al.
2021
PLOS ONE
Boosting understanding of Lassa Fever virus epidemiology: Field testing a novel assay to identify past Lassa Fever virus infection in blood and oral fluids of survivors and unexposed controls in Sierra Leone
Onome Akpogheneta , Steve Dicks ,Donald Grant,Zainab Kanneh, Brima Jusu, Joseph Edem-otah, Lansana Kanneh, Foday Alhasan, Michael Gbakie, John Schieffelin, Samreen Ijaz, Richard Tedder, Hilary Bower
2021
PLOS Neglected Tropical Diseases
In-Flight Transmission of SARS-CoV-2
Edward M. Choi, Daniel K.W. Chu, Peter K.C. Cheng, Dominic N.C. Tsang, Malik Peiris, Daniel G. Bausch, Leo L.M. Poon, and Deborah Watson-Jones
2020
Emerging Infectious Diseases
Transmission risk of respiratory viruses in natural and mechanical ventilation environments: implications for SARS-CoV-2 transmission in Africa
Anuoluwapo Sopeyin, Emilio HORNSEY, Tochi Okwor, Yewande Alimi, Tajudeen Raji, Abdulaziz Mohammed, Hiwot Moges, Ezinne V C Onwuekwe, Frank J Minja, Giorgia Gon, Onyema Ogbuagu, Folasade Ogunsola
2020
BMJ Global Health
Back to basics: the outbreak response pillars
Dale A Fisher, Gail Carson, on behalf of the GOARN Steering Committee
2020
The Lancet
Inactivation analysis of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents and fixatives
Stephen R. Welch, Katherine A. Davies, Hubert Buczkowski, Nipunadi Hettiarachchi, Nicole Green, Ulrike Arnold, Matthew Jones, Matthew J. Hannah, Reah Evans, Christopher Burton, Jane E. Burton, Malcolm Guiver, Patricia A. Cane, Neil Woodford, Christine B. Bruce, Allen D. G. Roberts, Marian J. Killip
2020
bioRxiv
COVID-19: Identifying countries with indicators of success in responding to the outbreak
David S. Kennedy, Hannah Ritchie, Rebecca Bartlein, Oliver Rothschild, Daniel G. Bauch, Max Roser, Anna C. Seale
2020
Gates Open Research
Learning from each other in the COVID-19 pandemic
Anna C. Seale, Maryirene Ibeto, Josie Gallo, Olivier le Polain de Waroux, Judith R. Glynn, Jenny Fogarty
2020
Wellcome Open Research
COVID-19: Shining the Light on Africa
Philip J. Rosenthal, Joel G. Breman, Abdoulaye A. Djimde, Chandy C. John, Moses R. Kamya, Rose G. F. Leke, Matshidiso R. Moeti, John Nkengasong and Daniel G. Bausch
2020
The American Society of Tropical Medicine and Hygiene
Factors Influencing Atypical Clinical Presentations during the 2017 Madagascar Pneumonic Plague Outbreak: A Prospective Cohort Study
Alex P. Salam, Mihaja Raberahona, Prisca Andriantsalama, Liam Read, Faraniaina Andrianarintsiferantsoa, Tiana Razafinambinintsoa, Rado Rakotomalala, Rodrigue N. E. Hasiniatsy, Dominique Razafimandimby, Lyndsey Castle, Anna Funk, Reziky T. Mangahasimbola, Bertrand Renaud, Eric Bertherat, Andrew Lovering, Jean-Michel Heraud, Voahangy Andrianaivoarimanana, Randrianirina Frédérique, Norosoa Razanajatovo, Laurence Baril, Arnaud Fontanet, Minoarisoa Rajerison, Peter Horby, Mamy Randria and Rindra Randremanana
2020
The American Journal of Tropical Medicine and Hygiene
Coronavirus: The psychological effects of quarantining a city
G James Rubin, Simon Wessely
2020
BMJ Opinion
The cost of insecurity: from flare-up to control of a major Ebola virus disease hotspot during the outbreak in the Democratic Republic of the Congo, 2019
Thibaut Jombart1, Christopher I Jarvis, Samuel Mesfin, Nabil Tabal, Mathias Mossoko, Luigino Minikulu Mpia, Aaron Aruna Abedi, Sonia Chene, Ekokobe Elias Forbin, Marie Roseline D Belizaire, Xavier de Radiguès, Richy Ngombo, Yannick Tutu, Flavio Finger, Madeleine Crowe, W John Edmunds, Justus Nsio, Abdoulaye Yam, Boubacar Diallo, Abdou Salam Gueye, Steve Ahuka-Mundeke, Michel Yao, Ibrahima Socé Fall
2020
Eurosurveillance
Preparedness for emerging epidemic threats: a Lancet Infectious Diseases Commission
Vernon J Lee, Ximena Aguilera, David Heymann, Annelies Wilder-Smith, Daniel G. Bausch, Sylvie Briand, Christianne Bruschke, Eduardo Carmo, Sean Cleghorn, Lalit Dandona, Christl Donnelly, Ibrahima Socé Fall, Jane Halton, Richard Hatchett, Felicia Hong, Peter Horby, Chikwe Ihekweazu, Michael Jacobs, Kamran Khan, Yijun Lin1, Gabriel Leung, Constance Low, Bethan Mcdonald, Ziad Memish, Ryan Morhard, Deborah Ng, John Nkengasong, Junxiong Pang, Stephen C. Redd, Karen Tan, Wenqing Yeo
2020
The Lancet Infectious Diseases
Effect of Acute Illness on Contact Patterns, Malawi, 2017
Judith R. Glynn, Estelle McLean, Jullita Malava, Albert Dube, Cynthia Katundu, Amelia C. Crampin, Steffen Geis
2020
Emerging Infectious Diseases
Event-based surveillance at health facility and community level in low-income and middle-income countries: a systematic review
Anna Kuehne, Patrick Keating, Jonathan Polonsky, Christopher Haskew, Karl Schenkel, Olivier Le Polain de Waroux, Ruwan Ratnayake
2019
BMJ Global Health
Clinical Research During Outbreaks (CREDO) Training for Low- and Middle-Income Countries
Nzelle Delphine Kayem, Amanda Rojek, Emmanuelle Denis, Alex Salam, Andreas Reis, Piero Olliaro, and Peter Horby
2019
Emerging Infectious Diseases
A systematic review and meta-analysis of patient data from the West Africa (2013–16) Ebola virus disease epidemic
A.M.Rojek, A.Salam, R.J.Ragotte, E.Liddiard, A.Elhussain, A.Carlqvist, M.Butler, N.Kayem, L.Castle, L.'O.Odondi, K.Stepniewska, P.W.Horby
2019
Clinical Microbiology and Infection
Lessons learnt from Ebola virus disease surveillance in Équateur Province, May–July 2018
Jonathan Polonsky, Franck Mboussou, Christopher Haskew, Olivier le Polain de Waroux, Marie Roseline Darnycka Belizaire, Vital Mondonge, Valentin Mukinda, Patricia Ndumbi Ngamala, Emilie Peron, Jillian Murray, Oliver Morgan, Mamoudou Harouna Djingareyb, Benido Impoumab
2019
World Health Organisation - Weekly Epidemiological Record, Special issue, 18 January 2019
A rapid research needs appraisal methodology to inform clinical research priorities in response to outbreaks - results from the Lassa fever pilot
Louise Sigfrid, Catrin Moore, Alex P Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke, Peter Horby
2019
BMC Medicine
Severe undifferentiated febrile illness outbreaks in the Federal Republic of Sudan – A retrospective epidemiological and diagnostic study
H. Bower, T.E. Fletcher, R. Mohamed, M. Alzain, A. Elhalawi, A. Osman, A. Semper, T. Brooks, J. Osborne, J. Furneaux, S. Dowall, V. Graham, G. Slack, R. Hewson, N. Beeching, J. Whitworth, D. Bausch, M. Mustafa
2019
International Journal of Infectious Diseases
Early transmission and case fatality of Ebola virus at the index site of the 2013–16 west African Ebola outbreak: a cross-sectional seroprevalence survey
Joseph W S Timothy, Yper Hall, Joseph Akoi-Boré, Boubacar Diallo, Thomas R W Tipton, Hilary Bower, Thomas Strecker, Judith R Glynn, Miles W Carroll
2019
Lancet Infectious Diseases
New Filovirus Disease Classification and Nomenclature
Jens H. Kuhn, Takuya Adachi, Neill K. J. Adhikari, Jose R. Arribas, Ibrahima Elhadj Bah, Daniel G. Bausch, Nahid Bhadelia, Matthias Borchert, Arne Broch Brantsæter, David M. Brett-Major, Timothy H. Burgess, Lado Marta Castro-Rial, Daniel S. Chertow, Christopher G. Chute, Theodore J. Cieslak, Robert Colebunders, Ian Crozier, Richard T. Davey, Hilde de Clerck, Rafael Delgado, Laura Evans, Mosoka Fallah, William A. Fischer II, Tom E. Fletcher, Robert A. Fowler, Thomas Grünewald, Andy Hall, Angela Hewlett, Andy I. M. Hoepelman, Catherine F. Houlihan, Giuseppe Ippolito, Shevin T. Jacob, Michael Jacobs, Robert Jakob, Frederique A. Jacquerioz, Laurent Kaiser, Andre C. Kalil, Rashidatu F. Kamara, Jimmy Kapetshi, Hans-Dieter Klenk, Gary Kobinger, Mark G. Kortepeter, Colleen S. Kraft, Thomas Kratz, Henry S. Kyobe Bosa, François Lamontagne; H. Cliff Lane, Leslie Lobel, Julius Lutwama, G. Marshall Lyon III, Moses B. F. Massaquoi, Thomas A. Massaquoi, Aneesh K. Mehta, Vital Mondonge Makuma, Srinivas Murthy, Tonny Seikikongo Musoke, Jean-Jacques Muyembe Tamfum, Phiona Nakyeyune, Carolina Nanclares, Miriam Nanyunja, Justus Nsio-Mbeta, Tim O’Dempsey, Janusz T. Pawęska, Clarence J. Peters, Peter Piot, Christophe Rapp, Bertrand Renaud, Bruce Ribner, Pardis C. Sabeti, John S. Schieffelin, Werner Slenczka, Moses J. Soka, Armand Sprecher, James Strong, Robert Swanepoel, Timothy M. Uyeki, Michel van Herp, Pauline Vetter, David A. Wohl, Timo Wolf, Anja Wolz Alie H. Wurie and Zabulon Yoti
2019
Nature Reviews Microbiology
The complex ethical landscape of biobanking
Jonathan W Ashcroft, Cheryl C Macpherson
2019
The Lancet Public Health
Shifting the Paradigm — Applying Universal Standards of Care to Ebola
William A Fischer II, Ian Crozier, Daniel G Bausch, Jean-Jacques Muyembe, Mulangu Sabue, Janet V Diaz, Richard Kojan, David A Wohl, and Shevin T Jacob
2019
New England Journal of Medicine
Pneumococcal conjugate vaccine use during humanitarian crises
Kevin van Zandvoort, Francesco Checchi, Emma Diggle, Rosalind M. Eggo, Kartini Gadroen, Kim Mulholland, Catherine R. McGowan, Olivier le Polain de Waroux, V. Bhargavi Rao, Catherine Satzke, Stefan Flasche
2019
Vaccine
Assessment of a health facility based active case finding system for Ebola virus disease in Mbandaka, Democratic Republic of the Congo, June-July 2018
Kunkel A, Keita M, Diallo B, le Polain de Waroux O, Subissi L8, Wague B, Molala, Lonfandjo P, Bokete SB, Perea W, Djingarey MH.
2019
BMC Infectious Diseases
Floods as Human Health Risks
Ellen Bloomer, Owen Landeg, Olivier le Polain de Waroux
2019
Encyclopedia of Environmental Health, 2nd Edition
Detection of Crimean-Congo Haemorrhagic Fever cases in a severe undifferentiated febrile illness outbreak in the Federal Republic of Sudan: a retrospective epidemiological and diagnostic cohort study
Hilary Bower, Mubarak El Karsany, Mazza Alzain, Benedict Gannon, Rehab Mohamed, Iman Mahmoud, Mawahib Eldegail, Rihab Taha, Abdalla Osman, Salim Mohamednour, Amanda Semper, Barry Atkinson, Daniel Carter, Stuart Dowall,Jenna Furneaux, Victoria Graham,Jack Mellors,Jane Osborne, Steven T. Pullan, Gillian S. Slack, Tim Brooks, Roger Hewson, Nicholas J. Beeching, Jimmy Whitworth, Daniel G. Bausch, Tom E. Fletcher
2019
PLOS Neglected Tropical Diseases
Personal protective equipment for viral hemorrhagic fevers
Raj, Deepaa; Hornsey, Emiliob; Perl, Trish M.
2019
Current Opinion in Infectious Diseases
Severe undifferentiated febrile illness outbreaks in the Federal Republic of Sudan – A retrospective epidemiological and diagnostic study
Bower, H, Mustafa, M, Alzain, M, Gannon, B, Elageb, R, Mahmoud, I, Eldegail, M, Taha, R, Semper, A, Atkinson, B, Carter, D, Dowall, S, Graham, V, Mellors, J, Pullan, S, Hewson, R, Beeching, N, Whitworth, J, Fletcher, T
2019
International Journal of Infectious Diseases
A qualitative study assessing the feasibility of implementing a group CBT based intervention in Sierra Leone
Waterman S, Cole CL, Greenberg N, Rubin GJ, Beck A
2018
British Journal of Psychiatry International
Planning for large epidemics and pandemics: challenges from a policy perspective
Vageesh Jain, Adriano Duse, Daniel G. Bausch
2018
Current Opinions in Infectious Diseases
Training peers to treat Ebola centre workers with anxiety and depression in Sierra Leone
WatermanS, Hunter ECM, Cole CL, Evans LJ, Greenberg N, Rubin GJ and Beck A
2018
International Journal of Social Psychiatry
The Epidemic Diseases Research Group field team. Clinical assessment is a neglected component of outbreak preparedness: evidence from refugee camps in Greece
Rojek AM, Gkolfinopoulou K, Veizis A, Lambrou A, Castle L, Georgakopoulou T, Blanchet K, Panagiotopoulos T, Horby PWand
2018
BMC Medicine
Real-Time Modeling Should be Routinely Integrated into Outbreak Response
Bausch DG and J Edmunds
2018
American Journal of Tropical Medicine and Hygiene
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria
Brenda A. Kwambana-Adams, Rahab C. Amaza, Catherine Okoi, Murtala Rabiu, Archibald Worwui, Ebenezer Foster-Nyarko, Bernard Ebruke, Abdul K. Sesay, Madikay Senghore, Abdullahi S. Umar, Rabi Usman, Adamu Atiku, Garba Abdullahi, Yahaya Buhari, Rabiu Sani, Husaini U. Bako, Bashir Abdullahi, Alliyu I. Yarima, Badaru Sikiru, Aderinola Olaolu Moses, Michael O. Popoola, Eme Ekeng, Adebola Olayinka, Nwando Mba, Adamu Kankia, Ibrahim N. Mamadu, Ifeanyi Okudo, Mary Stephen, Olivier Ronveaux, Jason Busuttil, Jason M. Mwenda, Mohammed Abdulaziz, Sulaiman A. Gummi, Adebayo Adedeji, Andre Bita, Linda Omar, Mamoudou Harouna Djingarey, Wondimagegnehu Alemu, Umberto D’Alessandro, Chikwe Ihekweazu, Martin Antonio
2018
Nature Scientific Reports
Isolation of viable Zika virus from spermatozoa
Alex Salam ;Peter Horby
2018
The Lancet Infectious Diseases
Outbreaks in a Rapidly Changing Central Africa — Lessons from Ebola
Vincent J. Munster, Daniel G. Bausch, Emmie de Wit, Robert Fischer, Gary Kobinger, César Muñoz‑Fontela, Sarah H. Olson, Stephanie N. Seifert, Armand Sprecher, Francine Ntoumi, Moses Massaquoi, Jean‑Vivien Mombouli
2018
New England Journal of Medicine
Action not justification: how to use social science to improve outbreak response
Hana Rohan, Daniel G Bausch, Karl Blanchet
2018
PLOS Channels
Health care worker vaccination against Ebola: vaccine acceptance and employment duration in Sierra Leone
Mario Jendrossek, John Edmunds, Hana Rohan, Samuel Clifford, Thomas A Mooney, Rosalind M Eggo
2018
Vaccine
Outbreak analytics: a developing data science for informing the response to emerging pathogens
Polonsky, Jonathan; Baidjoe, Amrish; Kamvar, Zhian; Cori, Anne; Durski, Kara; Edmunds, John; Eggo, Rosalind; Funk, Sebastian; Kaiser, Laurent; Keating, Patrick; le Polain de Waroux, Olivier; Marks, Michael; Moraga, Paula; Morgan, Oliver; Nouvellet, Pierre; Ratnayake, Ruwan; Roberts, Chrissy; Whitworth, Jimmy; Jombart, Thibaut
2018
Philosophical Transactions of the Royal Society B
Unrecognised Ebola virus infection in contacts: what can we learn from it?
Tom E Fletcher; Hilary Bower
2018
The Lancet Infectious Diseases
Rapid research needs appraisal methodology
Sigfrid L, Moore C, Garritty C, Maayan N, Lutje V, Marshall R, Salam A, Pestridge C, Buckley B, Soares-Weiser K, Clarke M, Horby P
2017
Open Access Framework
The Breadth of Viruses in Human Semen
Salam AP, Horby PW
2017
Emerging Infectious Diseases
Updates
Updates List Block
Research Fellow / Assistant Professor, UK-PHRST

We are seeking an outstanding Research Fellow or Assistant Professor to support the UK Public Health Rapid Support Team (UK-PHRST). The post-holder will contribute epidemiological and analytical expertise to support UK-PHRST’s strategic objectives in outbreak response, operational research, and capacity building, working in partnership with local and regional stakeholders. The role will also include representing the UK-PHRST at relevant external events, conferences and workshops.

The UK-PHRST is a collaborative partnership between the London School of Hygiene and Tropical Medicine (LSHTM) and Public Health England (PHE) that rapidly deploys a team of multidisciplinary public health professionals and researchers on behalf of the UK Government to areas of need in low and middle-income countries (LMICs). Application details here.

Deadline: Tuesday 28 September

Launch of the Itad Evaluation

Between September and November 2020, Itad conducted a number of Key Informant Interviews with stakeholders to gather evidence for the end-point evaluation of the UK Public Health Rapid Support Team (UK-PHRST) programme.

The purpose of the evaluation is to ensure independent monitoring and quality assurance of programme delivery, documentation of lessons learned, and robust tracking of results, providing assessment of the effectiveness of official development assistance (ODA) funds.

We are delighted to share these with you;

Dr. Ben Gannon appointed interim Director of the UK-PHRST

We are delighted to announce that Dr Ben Gannon has been appointed as the Interim Director of the UK Public Health Rapid Support Team (UK-PHRST). Ben has taken over the role from Professor Dan Bausch, who has accepted a post as Director of Global Health Security at the Foundation for Innovative New Diagnostics in Geneva. We would like to take this opportunity to thank Dan for his leadership of the UK-PHRST over the past four years.

Ben has worked in the UK-PHRST as the Microbiology Lead for the last five years, deploying on multiple occasions and building an extensive portfolio of overseas research and capacity development projects. He comes from an academic background, including specialising in zoonotic disease transmission and diagnostics at the University of Bristol. Later he joined the PHE Rare and Imported Pathogens Laboratory where he deployed to Sierra Leone on multiple occasions to support the Ebola diagnostic laboratory programme. Ben’s appointment is strongly supported by the Department of Health and Social care, as well as Public Health England and the London School of Hygiene & Tropical Medicine, the joint lead UK-PHRST partner organisations.

We are confident that the UK-PHRST is in excellent hands at this critical time.

UK-PHRST launch new COVID-19 Psychological First Aid course for Africa

Adapted by UK-PHRST staff, Dr Alice Walker, this course shows front-line responders how to recognise when people affected by the COVID-19 pandemic are in distress, and how to provide them with Psychological First Aid (PFA). It is specifically designed for first responders in Africa and reflects the different healthcare situations of African countries, drawing on guidance from the World Health Organisation and the United Nations, and has been adapted for the context by the UK-Public Health Rapid Support Team (PHE/LSHTM) with input by experts from WHO AFRO, WHO EMRO, Africa CDC, the West African Health Organization, and the East, Central and Southern Africa Health Community (ECSA-HC).

Take the course.

Deputy Director of Research, UK-PHRST

We are seeking an outstanding academic leader to serve as Deputy Director for Research for the UK Public Health Rapid Support Team (UK-PHRST). The post-holder will oversee and deliver the UK-PHRST research programme, building the evidence base for international disease outbreak response and interventions. The UK-PHRST is a high-profile collaboration between the London School of Hygiene and Tropical Medicine (LSHTM) and Public Health England (PHE), with a 5-year £20m grant from the UK government to support a triple mandate of outbreak response, outbreak-related research, and capacity building in low and middle-income countries (LMICs).  Application details here

Deadline: Sunday 03 January

Professor Daniel Bausch voted President-Elect of the American Society of Tropical Medicine & Hygiene

Prof Bausch has served on ASTMH’s executive committee as scientific program chair for the last six years, and was recently voted President-elect by the society’s members. ASTMH is the largest international scientific organisation of experts dedicated to reducing the worldwide burden of tropical infectious diseases and improving global health. Prof Bausch will serve a three-year term comprised of one year each as President-Elect, President, and Immediate Past-President.

As president, he will be responsible for steering the important work of ASTMH, which includes generating and sharing scientific evidence, informing health policies and practices around the world and advocating for investment in tropical medicine and global health research.

Prof Bausch said “I feel so fortunate to be elected to lead such a great and talented group of people at ASTMH who are so dedicated to making the world a better place. Furthermore, being based in London and engaging with the Royal Society over the past few years, I’m excited about the potential for ASTMH-RSTMH collaborations.”

Read the full story here.

What is your professional assessment of current and future COVID-19 interventions?

The UK Public Health Rapid Support Team (UK-PHRST) is conducting an online survey (until 25th October 2020) open to public health and healthcare professionals worldwide to understand their professional assessment of current and future COVID-19 interventions, specifically the practicality of, and barriers to, implementation in their context.   

Your participation is important to share learning to inform the COVID-19 response in your country and in others. The survey is available in English, French and Portuguese and is anonymous.  

For more information on how to complete the survey, please click here

Please help to share this with relevant professionals - many thanks for your valued support!

Launching the new UK-PHRST Knowledge Hub: Sharing knowledge saves lives

The UK-PHRST are pleased to announce the launch of their new Knowledge Hub, where practitioners and researchers can find and share the most useful information for their work in outbreak response. Hosted on The Global Health Network, the Knowledge Hub aims to:

  • Bridge the gap between the fast-paced world of online discussion forums and maintain long-term access to useful resources.
  • Share up-to-date research and policy, as well as a dedicated education and training area with resources to support learning and inform effective outbreak response.
  • Connect UK-based researchers with specialists in LMICs, creating a flow of information exchange and localised adaptations to outbreaks.

The new UK-PHRST Knowledge Hub provides a community function, allowing members to start group conversations around key topics, such as this timely post on contact tracing technology and comment on current issues, as shown in this blog on the importance of looking after Mental Health in COVID-19

We look forward to you joining, contributing and using our Knowledge Hub as a reliable and up-to-date source on outbreak response! Please do give us feedback on how you would like to see the UK-PHRST Knowledge Hub evolve in our discussion forum here.

 

Meet Ashley Sharp, our new Deputy Director of Operations!

Welcoming Ashley Sharp, a medical doctor before moving into public health and completing the UK Public Health Specialty Training Programme and the UK Field Epidemiology Training Programme (FETP). 

He has worked in a variety of public health roles at local, regional, national and international levels in the UK, Eswatini, Sierra Leone, Haiti and Bangladesh, with a focus on health protection and health systems development. He is also a member of the UK Faculty of Public Health, the standard setting body for public health specialists within the United Kingdom. 

Ashley joins the team as the Senior Epidemiologist and Deputy Director for Operations, replacing Olivier le Polain. 

GOARN: Congratulations on 20 years of service

The UK-PHRST notes that April 28th 2020 marks 20 years since the inception of the Global Outbreak Alert and Response Network (GOARN). For 20 years GOARN has facilitated and promoted partners to work together in tackling disease outbreaks across the world and by doing so, ensuring that the response can be greater than the sum of its parts. We congratulate GOARN for two decades of dedicated service, making the world a safer place. The UK-PHRST is proud to support GOARN, both through deployments in the field and strategic support through membership on the GOARN Steering Committee.  

The UK-PHRST responds to COVID-19

The UK-PHRST deploys specialist experts to outbreaks of infectious diseases overseas, to help increase and improve the response and reduce their risk of becoming global threats. As COVID-19 has shown, diseases don’t respect borders. In February and March the UK-PHRST deployed, both through GOARN and bilateral agreements, to combat COVID-19, working alongside colleagues from the World Health Organisation (WHO), Ministries of Health and others in the WHO Western Pacific Regional Office in the Philippines, WHO Country Office in Nepal, Nigeria CDC, and Africa CDC in Ethiopia to deliver expertise in epidemiology, data analysis, infection prevention and control, clinical care, laboratory diagnostics, social science, logistics, and strategic guidance.

Although global travel restrictions have now necessitated recalling all personnel back to the UK, the UK-PHRST continues to provide support remotely to the aforementioned partners, as well as to the WHO African Regional Office in the Republic of the Congo and WHO Country Office and Ministry of Health in Bangladesh. In addition to their support to partners overseas, many UK-PHRST team members are also supporting the domestic response, providing clinical care and epidemiologic support. The UK-PHRST is also engaged in developing and implementing several research projects on COVID-19 and has organized a Massive Open Online Course (MOOC) on COVID-19 through LSHTM, which has nearly 200,000 registrants. 

UK Public Health Rapid Support Team Director, Dan Bausch contributes to The Lancet Infectious Diseases Commission on preparedness for emerging epidemic threats

At any time, an emerging, lethal, and highly transmissible pathogen might pose a risk of being spread globally because of the interconnectedness of the global population.1, 2 Emerging epidemic threats are occurring with increasing scale, duration, and effect, often disrupting travel and trade, and damaging both national and regional economies.3, 4 Even geographically limited outbreaks such as the Ebola virus disease in Africa might have a global effect.

Read the full comment

Building in-country capacity for genetic sequencing: NCDC National Reference Laboratory

The UK-PHRST has been working closely with the Nigeria Centre for Disease Control (NCDC) to improve knowledge on Lassa fever by identifying other pathogens that may be causing similar illnesses. A recent Weekly Epidemiological Report from NCDC features an update on this work, which is taking place at the NCDC National Reference Laboratory.

It's hoped the work could lead to improved patient care, better surveillance data, and will inform public health policy. As well as broadening the scientific knowledge base on the topic, this collaboration is supporting the growth of in-country capacity for genetic sequencing in Nigeria and leadership by local experts.

Find out more

Disease outbreaks in low and middle income countries: New free online course launched

Experts from the UK Public Health Rapid Support Team have contributed to a new Massive Online Open Course (MOOC) from the London School of Hygiene & Tropical Medicine.

This course is for those interested in, studying or working in global and public health. This includes government stakeholders; health practitioners and NGO employees - particularly those working in countries regularly affected by infectious disease outbreaks.

Recent outbreaks of emerging and re-emerging infectious diseases have shown we need to be able to coordinate responses to disease outbreaks at the regional, country and global level. On this free course, participants will explore disease outbreaks, discovering what outbreaks are and why they matter as well as the different responses to such outbreaks. They will also consider the future of outbreak preparedness.

Find out more

UK Public Health Rapid Support Team deploys more experts to support Ebola outbreak response

Public health specialists from the UK Public Health Rapid Support Team are supporting the Democratic Republic of Congo to tackle the country’s Ebola outbreak as it reaches the one-year mark.

Those deploying to the country include a data scientist, an expert in tracking outbreaks (epidemiologist), and an infection and prevention control expert who will work with local scientists. The deployment is at the request of the World Health Organization’s Global Outbreak Alert and Response Network following the recent decision to declare the outbreak a Public Health Emergency of International Concern.

Read the full announcement

Chief Medical Officer recognises contribution of UK-PHRST to improving global health

In her final annual report before leaving the role, Dame Sally Davies – Chief Medical Officer, England, and Chief Medical Advisor to the UK – chose to ‘address the UK’s engagement with health at a global level’. Her report showcases the work of the UK Public Health Rapid Support Team and includes a case study of the team’s work to support Nigeria in tackling Lassa Fever.

Read the full report

What is it like responding to the ongoing Ebola outbreak in the Democratic Republic of Congo and deploying to emergencies?

Q&A with UK-PHRST’s Dr Olivier le Polain. 

Olivier le Polain is the senior epidemiologist and deputy director for operations of the UK Public Health Rapid Support Team.

He has been a member of the team for just under two years and in that time has deployed to Madagascar to respond to an outbreak of pneumonic plague, to Bangladesh amidst the Rohingya refugee crisis and most recently to the Democratic Republic of Congo. The latter was to support the response to two consecutive Ebola virus disease (EVD) epidemics, one in Equateur Province (May – July 2018) as well as the ongoing large outbreak which has affected the Eastern provinces of North Kivu and Ituri since August 2018.

Olivier talks about his experience on the ground in the DRC during the ongoing Ebola epidemic, the importance of working in partnership with other countries and organisations and his experience on the UK-PHRST so far. 

Read the interview

Online to on the ground – helping health workers engage with local communities during epidemics

A new online resource which aims to strengthen the control response to disease outbreaks has been developed by the London School of Hygiene & Tropical Medicine (LSHTM) and the Institute of Development Studies. The Epidemic Response Anthropology Platform is funded by the UK-PHRST and will work with, and build, networks of anthropologists and other social scientists with regional or subject expertise, and connect them to policymakers, scientists and humanitarian response workers involved in responding to epidemics.

Read the full story

Ebola Outbreak: UK Public Health Rapid Support Team deploying to DRC

On 8 May 2018, the Democratic Republic of Congo (DRC) Government declared a new outbreak of Ebola Virus Disease (EVD)—the country’s ninth outbreak. The UK-PHRST is deploying to the Democratic Republic of Congo to help control the outbreak. The three UK-PHRST team members deploying include two experts in tracking outbreaks, LSHTM’s Hilary Bower and Olivier le Polain from Public Health England, and data scientist Patrick Keating from LSHTM.

The team is expected to remain in the DRC for around six weeks, during which time they will help track the spread of the outbreak, and will also support in establishing robust data systems that will help align crucial information gathering. The UK-PHRST also has expertise in various other key areas for Ebola response, such as laboratory diagnostics, that can be deployed should they be needed.

Read the full announcement

How does the UK Public Health Rapid Support Team investigate and respond to disease outbreaks?

Q&A with team Director, Prof Dan Bausch.

In April 2017, Professor Daniel Bausch was appointed Director of the UK-PHRST. Prof Bausch is a specialist in emerging infectious diseases trained in internal medicine, infectious diseases, tropical medicine, and public health. He has extensive experience in sub-Saharan Africa, Latin America, and Asia combatting deadly global health threats such as Ebola virus, hantavirus, and SARS coronavirus.

A year on from the team's first deployment, Prof Bausch tells us more about the team and how they work to assist in managing disease outbreaks.

Read the interview

Events
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Knowledge Hub
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UK-PHRST Global Health Network and UKHSA logo

Responding effectively to outbreaks of infectious diseases saves lives. Sharing knowledge, learning, and experience of outbreak response across geographies, diseases, and between researchers and policy makers is essential. Without collaboration, outbreaks risk spreading in size and scale.

The UK Health Security Agency and the London School of Hygiene & Tropical Medicine came together in 2016 to form the UK Public Health Rapid Support Team (UK-PHRST), with an academic consortium including the University of Oxford. The UK-PHRST’s integrated tripartite remit includes outbreak response, research, and capacity building.

Funded by UK aid from the Department of Health and Social Care, UK-PHRST supports low- and middle-income countries (LMICs) in investigating and responding to disease outbreaks and conducts research to improve our response to future epidemics.

The UK-PHRST are pleased to announce the launch of their new Knowledge Hub, where practitioners and researchers can find and share the most useful information for their work in outbreak response.

Hosted on The Global Health Network, the Knowledge Hub aims to:

  • Bridge the gap between the fast-paced world of online discussion forums and maintain long-term access to useful resources.
  • Share up-to-date research and policy, as well as a dedicated education and training area with resources to support learning and inform effective outbreak response.
  • Connect UK-based researchers with specialists in LMICs, creating a flow of information exchange and localised adaptations to outbreaks.

Many of these resources have been developed by UK-PHRST and its partners, including a number of virtual learning resources on COVID-19.

The new UK-PHRST Knowledge Hub provides a community function, allowing members to start group conversations around key topics, such as this timely post on contact tracing technology and comment on current issues, as shown in this blog on the importance of Looking after Mental Health in COVID-19.

We look forward to you joining, contributing and using our Knowledge Hub as a reliable and up-to-date source on outbreak response! Please do give us feedback on how you would like to see the UK-PHRST Knowledge Hub evolve in our discussion forum here.

About The Global Health Network

Faster and better research is critical to solving the world’s biggest health challenges. The Global Health Network enables researchers and institutions to share best practice and know-how with each other to drive progress, while empowering local health professionals undertaking research in the world’s most vulnerable settings. The Global Health Network facilitates sustainable health improvements through sharing of research methods, knowledge and experience through an open-access online platform and face-to-face within varied healthcare settings. It delivers training, skills and career development to frontline health workers, no matter where they are or how resource-constrained their environment may be. The result is easier, faster, better research to help address the world's biggest health challenges.

Visit: www.theglobalhealthnetwork.org.

Case Studies
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The UK-PHRST are deployed to outbreaks all over the world from Bangladesh to Nigeria to Sudan. Working alongside in-country staff from Minstries of Health, NGOs and other government organisations, UK-PHRST successfully help combat the outbreak and protect against future threats to health. Read some of our stories below:

Using PPE in outbreak response

The UK Public Health Rapid Support Team (UK-PHRST), funded by UK aid from the Department of Health and Social Care, supports low- and middle-income countries in investigating and responding to disease outbreaks and conducts research to improve our response to future epidemics.

Our expertise in infection and prevention and control, which includes the use of Personal Protective Equipment (PPE), is used to protect people from infection in disease outbreaks. PPE can diminish transmission when used as part of an integrated package of measures, and crucially helps protect medical staff from disease, but there is variation in the need for, and use of PPE for different diseases, across countries, and differing views on its necessity.

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This project investigated the use of PPE to protect people from Lassa Fever, in specific Lassa Fever Treatment Centres (LTCs) across Nigeria.

Lassa fever is often confused with Ebola or other viral haemorrhagic fevers, but it differs - it is less fatal, and its transmission is very different. Ebola is transmitted between people, whereas Lassa fever is spread to most people (~80%) through exposure to food or household items contaminated by ratsLess commonly, transmission can occur in laboratories, or between people, particularly in health care settings with inadequate infection prevention and control measures.
 
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Why are the UK-PHRST involved?

Lassa Fever is an important cause of outbreaks of infectious disease. It is one of the pathogens in the World Health Organizations’ list of epidemic threats needing urgent research. The disease is endemic in rodent populations in parts of West Africa including Benin, Ghana, Guinea, Liberia, Mali, Sierra Leone, Togo, and Nigeria, and most likely exists in other West African countries as well. Cases are increasing in Nigeria.

The nuances between viruses causing haemorrhagic fevers, such as Ebola and Lassa Fever, are not translated into official guidance, and policies end up addressing them in the same manner. In addition, much of the research and guidance for PPE are developed in high-income settings, where there are few cases of disease, therefore the guidance is built on data, rather than lived experience. 

Recognising limitations in existing guidance, The Nigerian Centre for Disease Control (NCDC) invited the UK-PHRST work with them to investigate whether their infection, prevention and control (IPC) policies devised in 2017 were effectively disseminated and how, in the case of Lassa Fever, they were operationalised.

A woman suspected of contracting Lassa Fever awaits her lab results in quarantine. Suspect cases of Lassa Fever typically wait 12-24 hours for their samples to be tested locally at the virology laboratory. If positive they are moved by ambulance to the confirmed case ward a short distance away.
A woman suspected of contracting Lassa Fever awaits her lab results in quarantine. Suspect cases of Lassa Fever typically wait 12-24 hours for their samples to be tested locally at the virology laboratory. If positive they are moved by ambulance to the confirmed case ward a short distance away.

What did they discover? 

The team found that health care workers in Lassa treatment centres (LTCs) were frequently not using PPE in line with government guidelines. Limited availability of PPE in some centres led to health care workers using personal risk assessments to drive decision-making about its use, and there is a gap in understanding of staff perceptions, and how they protect themselves, in the absence of adequate PPE.

During interviews, researchers noticed that much importance was placed on the language, behaviour and understanding of PPE by the health workers. For example, some staff were basing their decision-making on what they perceived as ‘careful’ best practice, but this is not reflected in guidance. Staff also consistently expressed challenges with using PPE,  for example in the environment they were using it in (high temperatures), with poor quality materials (gloves breaking or tearing), and limited function (reduced visibility when using eye protection).

Inside the grounds of the Federal Training Hospital (FETHA) in Abakaliki, a makeshift Lassa Fever holding centre is prepared for quarantining of suspected cases.
Inside the grounds of the Federal Training Hospital (FETHA) in Abakaliki, a makeshift Lassa Fever holding centre is prepared for quarantining of suspected cases.

To mitigate some of these issues, some health workers adapted PPE to suit their local context; for example, choosing to wear a surgical gown in replacement of gowns provided, saying they were cooler to wear and simpler to remove.

The study team observed that judgements made by health workers were based on their experience and understanding of the situation, and this was very different to PPE guidance from international and national bodies.

Demonstrating a correctly prepared personal protective equipment suit
Demonstrating a correctly prepared personal protective equipment suit

In low- and middle-income countries (LMICs), funds assigned for PPE procurement and supplies can be limited. Where there are competing demands, funds are often redirected to more immediate requirements, such as emergency operations, or treatments.  

Alongside this, there were worries that the PPE provided was substandard. Much of the PPE in use had been donated, for example from non-governmental organisations, and there was no formal process in place to ensure it was fit for purpose.

Capacity building: Preventing future fires

As a result of the collaborative work carried out in the LTCs, The Nigeria Centre for Disease Control (NCDC) has revised national guidance on infection prevention control for viral haemorrhagic fevers.

Together with this success, emphasis on the quality of PPE facilitated prompted dialogue at a national level about developing assurance systems so that donation of equipment is fit for purpose in the future. These results have informed national advocacy work for improvements to supplies to Lassa Treatment Centres – with the ultimate aim of reducing countrywide infection.

Dr Abdulmajid Suleiman Musa shows a group of NCDC staff how a correctly prepared PPE suit should look when working in a virus hit region, Keffi, Nasarawa state.
Dr Abdulmajid Suleiman Musa shows a group of NCDC staff how a correctly prepared PPE suit should look when working in a virus hit region, Keffi, Nasarawa state.
Nurse Mary Obasi measures the temperature of woman with Lassa Fever in the confirmed ward at the FETHA 02 facility, Abakaliki, Ebonyi state
Nurse Mary Obasi measures the temperature of woman with Lassa Fever in the confirmed ward at the FETHA 02 facility, Abakaliki, Ebonyi state

How can this work be translated into other contexts?

There has also been ongoing professional collaboration between the NCDC as part of the COVID-19 response with Africa Centre for Disease Control and as part of the African Union Taskforce for COVID-19.

Thinking through novel and more nuanced approaches to PPE is useful when considering PPE for COVID-19. It is also helpful in the face of supply chain issues, with many countries unable to source PPE during the pandemic. Rational use of PPE has been suggested to mitigate insufficient PPE supplies.

While COVID-19 has brought worldwide disruptions to PPE supplies, and its availability, the experience of clinicians in LMICs has much to teach us all about the realities of working with limited resources; developing adaptations and creating innovative local solutions. However, it is important that guidelines are rooted in evidence-based best practise, as well as reflecting the reality of those who are required to implement them.

Read the updated guidelines and vital role the NCDC plays in keeping hospitals, clinics, and health facilities safe and free from disease.

Mystery pathogens and the role of the modular flight case mobile laboratory

Funded by UK aid from the Department of Health and Social Care, the multidisciplinary nature of the UK Public Health Rapid Support Team (UK-PHRST) allows its outbreak response support to take many forms, depending on the situation, and includes a mobile laboratory that can be deployed worldwide. This enables instant diagnostic capacity to process samples, identify causal agents, and tackle disease outbreaks.

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The Philippines, like many tropical countries, has a wide variety of infectious agents circulating that cause febrile illness and severe disease. Patients presenting with febrile symptoms could be infected with dengue, yellow fever, zika, or malaria, for example. When there is a spike in fever cases in any country, it is vital that the diagnostic tests can accurately describe the pathogen or ‘causal agent’ – to facilitate appropriate treatment and prevent further spread.

Why are the UK-PHRST involved?

Dengue is a mosquito-borne viral disease that has rapidly spread in all regions of WHO in recent years. The Americas, South-East Asia and Western Pacific regions are the most seriously affected, with Asia representing ~70% of the global burden of disease. As part of its public health system to identify cases, and outbreaks, it is compulsory to record dengue cases in The Philippines. This enables trends to be analysed which provides potential notice for future outbreaks.

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Dengue is a disease that not only has a high impact on health of the population, but also a large impact economically, therefore it is essential to identify outbreaks with the end goal of using targeted control measures to help combat the spread and repercussions.

So how are they tracking cases? 

A national surveillance programme tracks cases countrywide, with 21 disease reporting units across 17 regions – 4 in the national capital region. The units are housed in hospitals and clinics. Many of the reported cases are ‘suspected dengue’ where the patient has presented clinical symptoms, but this has not necessarily been followed up with a laboratory test due to limited diagnostics.

From the national surveillance programme, the UK-PHRST identified >4,000 patients, including more than 1,000 with severe disease, that had been tested and actually found to be dengue negative. From these, UK-PHRST prioritised samples from severe cases and identified ~400 to analyse (2015-2016). Then they sought to identify the unknown cause(s), the so called ‘mystery pathogen(s)’ of this febrile illness.

The role of the modular flight case mobile laboratory

To test and diagnose disease, UK-PHRST deployed research expertise and various components of the modular flight case laboratory via airline courier to The Philippines. Inside this mobile laboratory are two very sophisticated pieces of kit, previously not used in-country, a MinION and a Film Array. Both accurately diagnose disease by analysing the genetic code and comparing it with an existing database of genetic material. This process is called metagenomics.

Metagenomics identifies the closest strains or sequences of disease, which can also give the transmission patterns and geographical origin.

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How does this differ from current diagnostics?

Through use of metagenomics, all genes from the sample are sequenced, rather than specifically testing for an individual pathogen. Film Array is useful because it has the capacity to detect a range of pathogens, then the MinION enables precise confirmation of the causal agent. Because all the DNA is sequenced using these techniques, it gives scientists the ability to spot any disease, as well as find new strains of diseases.

Interestingly, within the samples there was lots of dengue present, despite testing negative. This suggests a new strain is not being picked up by the existing diagnostic tests.

Prior to the arrival of the mobile laboratory in The Philippines, diagnostics were only available for diseases the test is designed to recognise – allowing new strains to go under the radar.

How were the samples previously tested?

Samples can be tested in the Philippines, but the majority of sequencing would be carried out in labs overseas. For various reasons, this makes the process longer and creates a gap between sample collection and identification of the unknown pathogen, and all the time the outbreak can increase.

Firstly, there is difficulty shipping samples overseas because you need national and institutional approvals. Testing for Dengue is a lab bench process in The Philippines since it is as common as ‘flu. Elsewhere, such as the UK, dengue is very rare, therefore, to work on the virus itself research is contained within a category 3 laboratory and requires certain standards of biohazard safety. DNA needs to be transferred into RNA to be categorised as ‘uninfectious’ before shipping, and again, this increases the length of the process.

Having the in-country capacity to process samples makes a huge difference to the diagnosis and prevention of outbreaks.

Will this work continue? 

The UK-PHRST tested three batches using these techniques, with 31/107 samples processed. As a result of the deployment, the team at Research Institute for Tropical Medicine in Manila are trained and equipped to test the next few batches.

To train a laboratory scientist on a Film Array, it requires one or two sessions of a couple hours each. A MinION takes slightly longer and training can be up to a week, as you are required to initially prepare and clean the sample. The time-consuming component is the analysis, with plenty of training and biological theory involved. As this is work with datasets, this part of the process can be supported remotely.

UK-PHRST can train and equip a team with the necessary techniques to diagnose unknown disease outbreaks within three weeks of the mobile laboratory arriving in the country.

The in-country team are then better prepared to manage further outbreaks without direct support.

Can this be used in other outbreak settings?

Any additions to the global database of genetic material from pathogens can assist with the diagnosis of future disease outbreaks worldwide. Scientists use these data to compare the genetic code to this database and further develop diagnostics for fever cases in many different settings.

In Sudan, the UK-PHRST used minimal components of the modular flight case laboratory to determine the requirements for metagenomic sequencing and analysis. 32 samples were sequenced in-country and Chikungunya virus was identified

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In all 139 samples sequenced, Chikungunya virus was identified in 84%, with the metagenomic approach also identifying co-infections in six patients including ‘Dengue 4’ - not previously known to be circulating in Sudan.

"This case study shows the UK-PHRST are able to deploy a mobile laboratory providing cutting-edge diagnostic capabilities matching even the best ‘static’ laboratories. However, the value of this lab reaches beyond just doing the science and diagnostics; it provides a mobile training facility allowing local scientists, in countries such as the Philippines and Sudan, to learn and experience new techniques and develop their own scientific skills."
Dr Ben Gannon

 

The use of this method in Khartoum, Sudan, demonstrated capability to identify previously unknown pathogens. This shows that during an outbreak, the UK-PHRST can effectively deploy laboratory equipment to provide high level diagnostic capability, which is often unavailable even in most high-income health facilities.

The work of the mobile laboratory makes outbreak response more efficient, better equipped, and ready to tackle mystery pathogens all over the world.


Join the UK-PHRST Knowledge Hub here to find out more. 

What does it take to deploy in 48 hours?

No two outbreaks are the same. Having completed 19 deployments between April 2017 and November 2020, the operations team can safely testify that there is a need to remain alert, agile, and consistently open to change. Regardless of the mode of deployment, destination or disease, there are always new challenges to navigate.

For example, the suspension of air travel, resulting from border controls during the COVID-19 pandemic, led the team to explore new and innovative ways to offer technical support. Technical expertise was delivered remotely alongside a wide range of partners (including WHO Bangladesh and Africa CDC). This offered opportunities for reservist staff who may not be released for a six-week deployment to volunteer their support.

A full summary of deployments up to November 2020 below:

UK-PHRST deployments map

We will summarise the operational requirements to deploy UK-PHRST staff and reflect on what it takes to be operationally ready.

Onboarding staff:

Feedback from a wide range of governmental and non-governmental organisations supported the creation of processes to support the onboarding and advanced preparation of deployable staff.

  • Medical
    It is critical that individuals are medically fit for deployment and have all the necessary routine vaccinations to support their health and wellbeing whilst overseas. A routine schedule of vaccinations alongside a comprehensive medical assessment is required on appointment to the team. Individuals are then issued with an emergency medications kit, first aid kit and trauma kit (and of course, the training on what to do them).

  • Training
    In addition to the necessary technical training, UK-PHRST individuals undertake mandatory UK-PHRST training which aims to prepare them for operating effectively overseas. This includes residential safety and security training, safeguarding training and an immersive 5-day deployment course alongside a package of online learning.

  • Logistics
    Deployed staff are given a comprehensive kit to support their deployment, which includes resources for a wide range of environments (e.g. IT equipment, tents, mosquito nets, water chlorination tablets and ration packs). This kit is systematically reviewed, managed, and maintained by the operations team. external audits of the kit have taken place to ensure rigor and continual improvements are made.

  • Deployment handbook
    This is a guidance document containing all the processes and procedures required of UK-PHRST staff. It incorporates all feedback to date and serves to anticipate any questions relating to finance, medical support, incidents, travel, logistics and more.

Accepting a request to deploy:

When the UK-PHRST Director receives a request to deploy, the following steps are taken;

 

  • Criteria – Considerations to deploy include the country, infectious disease agent, location, partners already engaged and threat to further spread (particularly cross border).
  • Approval – A Cross-Government protocol (developed in advance with key partners) ensures rapid consideration of any request received by HMG departments. This protocol has been revised several times and represents the key approval mechanism for the team to deploy.

 

To prepare for deployment:

Once a deployment has been accepted, the team are sent additional information;

  • Risk assessment – a travel risk assessment is prepared in advance and includes any known hazards and mitigating actions in relation to the specific deployment, pathogen and country.
  • Information pack– includes country and disease specific documentation to aid preparations.
  • Pre-deployment briefing – A meeting is set up with the Director, deploying team and key UK-PHRST members to discuss a range of aspects relating to the deployment. This is an opportunity for the individuals to ask any questions and includes, but is not limited to, input from subject matter experts, medical advice, logistics and admin support.

In the field:

Whilst in the field team members have access to a wide range of 24/7 support from the UK based team. They also benefit from access to a dedicated nurse within the PHE Occupational Health team.

Reporting of any health and safety incidents or other concerns is done through a systematic process which links in with PHE reporting policies.