Close

Dr Fiona Cresswell

Clinical Associate Professor and Honorary Consultant in HIV and Sexual Health

United Kingdom

I am a physician in HIV and Sexual Health at University Hospital Sussex and an active clinician scientist working on improving the treatment of HIV and opportunistic infections in sub-Saharan Africa. I undertook an LSHTM Wellcome-funded PhD based at the Infectious Diseaes Instituite in Uganda and I remain involved in brain infection research with the meningitis team. I work closely with the MRC/UVRI-LSHTM Uganda Research Unit through a Wellcome Early Career Award which aims to support the effective and equitable implementation of long-acting HIV treatments in programmatic care settings in Africa. I am co-Chair of an interntional HIV conference - the African Workshop in HIV and Women. I am Chair of the British HIV Association Education and Scientific Committee. 




Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I supervise Msc and PhD candidates at LSHTM and Brighton and Sussex Medical School

Faculty on the East African Diploma in Tropical Medicine and Hygiene 2010 - 2019. 
HIV/TB module lead on the EADTMH in 2019.

TB module coordiantor in UK DTMH in 2023. 
I regularly examine medical student OSCEs for Brighton and Sussex Medical School

I have examined medical student OSCEs for Makerere University in Uganda

I am co-Chair of an international conference - the African Workshop in HIV and Women

I am Chair of the BHIVA Education and Scientific Committee

Research

My interests lie in HIV treatment, the diagnosis and treatment of HIV-related opportunistic infections. I am Chief Investigator of a phase III randomised clinical trial called IMPALA 'Improving HIV outcomes in Africa with Long-acting Antiretroviral therapy' so I work closely with colleagues at the trial coordinating centre at MRC/UVRI-LSHTM Uganda Research Unit and collaborators in Uganda, Kenya and South Africa. Through a Wellcome Early Career Award I am investigating the clinical pharamcology of long-acting HIV treatment in Africa with a view to personalising therapy. I am also site-investigator on the Cabotegravir and Rilpivirine Efficacy and Safety (CARES) study in Uganda. I lead an observational study on injectable HIV treatment in the UK. I continue to study TB meningitis an Investigator on the HARVEST multi-country trial of high-dose rifampicin for TB meningitis at the Infectious Diseases Institute, Uganda, Caprisa in South Africa, Oxford University Clinical Research Unit in Indonesia, Universities Padjadjaran, Radboud University in the Netherlands and University of Minnesota. My areas of expertise are in clinical trials, clinical pharmacology and translational research.

Research Area
Clinical care
Clinical guidelines
Clinical trials
Diagnostics
Global Health
Medicines
Pharmacokinetics
Sexual health
Epidemiology
Medicine
Pharmacology
Disease and Health Conditions
HIV/AIDS
Syphilis
Tropical diseases
Tuberculosis
Infectious diseases
Sexually transmitted infections
Country
Indonesia
Netherlands
Uganda
United Kingdom
United States
Region
Sub-Saharan Africa (developing only)

Selected Publications

Standardized Urine-Based Tuberculosis (TB) Screening With TB-Lipoarabinomannan and Xpert MTB/RIF Ultra in Ugandan Adults With Advanced Human Immunodeficiency Virus Disease and Suspected Meningitis.
CRESSWELL, FV; ELLIS, J; Kagimu, E; Bangdiwala, AS; Okirwoth, M; Mugumya, G; Rutakingirwa, M; Kasibante, J; Quinn, CM; Ssebambulidde, K; Rhein, J; Nuwagira, E; Tugume, L; Martyn, E; Skipper, CP; Muzoora, C; GRINT, D; Meya, DB; Bahr, NC; ELLIOTT, AM; Boulware, DR;
2020
OPEN FORUM INFECTIOUS DISEASES
Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study.
CRESSWELL, FV; Tugume, L; Bahr, NC; Kwizera, R; Bangdiwala, AS; Musubire, AK; Rutakingirwa, M; Kagimu, E; Nuwagira, E; Mpoza, E; Rhein, J; Williams, DA; Muzoora, C; GRINT, D; ELLIOTT, AM; Meya, DB; Boulware, DR; ASTRO-CM team,;
2020
The Lancet. Infectious diseases
Erratum to: The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015-2017.
ELLIS, J; Bangdiwala, AS; CRESSWELL, FV; Rhein, J; Nuwagira, E; Ssebambulidde, K; Tugume, L; Rajasingham, R; Bridge, SC; Muzoora, C; Meya, DB; Boulware, DR;
2019
OPEN FORUM INFECTIOUS DISEASES
Recent Developments in Tuberculous Meningitis Pathogenesis and Diagnostics.
CRESSWELL, FV; Davis, AG; Sharma, K; BASU ROY, R; Ganiem, AR; Kagimu, E; Solomons, R; Wilkinson, RJ; Bahr, NC; Thuong, NT T; Tuberculous Meningitis International Research Cons,;
2019
Wellcome Open Research
Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study.
Nsangi, L; HALE, G; Dai, B; Hullsiek, KH; Tukundane, A; Namudde, A; Menya, GB; Ayebare, P; Nankungu, L; Namuju, OC; Mulwana, S; Kabahubya, M; Meya, DB; Boulware, DR; CRESSWELL, FV; Bahr, NC; Abassi, M; ELLIS, J;
2026
Open forum infectious diseases
Cerebrospinal Fluid Hypo-inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis.
Wilt, AL; Meya, DB; CRESSWELL, FV; Wele, A; Kabahubya, M; Kagimu, E; Gakuru, J; Mugabi, T; Kimuda, S; Namombwe, S; Tukundane, A; Okafor, EC; Okurut, S; Scriven, JE; Dai, B; Engen, N; Bahr, NC; Boulware, DR; Bold, TD;
2026
The Journal of infectious diseases
Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis.
Meya, DB; CRESSWELL, FV; Dai, B; Engen, N; Naidoo, K; Ganiem, AR; Imran, D; Kabahubya, M; Lessells, RJ; Yunivita, V; Estiasari, R; Tugume, L; Hlabisa, B; Kurniawati, MY; Sagita, N; Kagimu, E; Maharani, K; Gakuru, J; Gaharu, MN; Mugabi, T; Kimuda, S; Namombwe, S; Te Brake, L; Aarnoutse, R; Svensson, EM; ... HARVEST Trial Team,
2025
The New England journal of medicine
Cabotegravir and rilpivirine for treatment of HIV infection in Africa: week 96 results from the phase 3b randomized, open-label, noninferiority CARES trial.
Kityo, C; Mambule, IK; Musaazi, J; Sokhela, S; Mugerwa, H; Yawe, I; CRESSWELL, F; Siika, A; Kosgei, J; Shah, R; Naidoo, L; Opiyo, K; Otike, C; Möller, K; Okwero, M; Wambui, C; Van Eygen, V; Mohammed, P; Addo Boateng, F; PATON, NI; CARES trial team,;
2025
Nature medicine
Integrating metagenomic sequencing into diagnostic pathways for tuberculous meningitis - Authors' reply.
Donovan, J; CRESSWELL, FV; Figaji, A; Thwaites, GE;
2025
The Lancet. Infectious diseases
C-Reactive Protein in Tuberculous Meningitis: A Viable Biomarker for Individualized Care.
Tugume, L; CRESSWELL, FV; Bahr, NC; Dai, B; Engen, N; Meya, DB; Boulware, DR;
2025
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
See more information