Dr Fiona Cresswell
PhD MBChB BSc MRCP DTMH PGCert Epi DipHIV
Academic Clinical Lecturer
I am a Physician with a clinical and academic interest in HIV, particularly the prevention and management of advanced HIV disease. I'm an investigator in two clinical trials determining whether novel approaches to HIV treatment, such as injectable antiretroviral therapy, are safe and effective in sub-Saharan Africa (IMPALA and CARES studies).
I completed a Wellcome Clinical PhD in 2021, the focus of which was improving diagnosis and treatment of HIV-associated TB meningitis. I am part of the International TB Meningitis Research Consortium and the HARVEST clinical trial consortium investigating high dose rifampicin for TB meningitis in Uganda, South Africa and Indonesia.
I have had the pleasure of being a tutor on the East African Diploma in Tropical Medicine and Hygeine since its inception in 2011. I do clinic-based teaching with undergraduate medical students at Brighton and Sussex University Hospital.
My research projects include:
- Diagnostics: I am collaborating with neurologists at the University of California San Francisco who are using next generation sequencing technologies to better understand the aetiology of brain infections in advanced HIV disease. We have also recently investigated FujiLAM in TB meningitis.
- HIV treatment: I am keen to investigate long-acting injectable antiretroviral therapy in stable HIV and in unstable populations in sub-Saharan Africa.
- TB meningitis treatment: As part of a collaboration with researchers in Indonesia, South Africa, Uganda, Netherlands and USA we are investigating higher dose of rifampicin through a phase III trial (Harvest).
- Transmission of HIV and STIs: I have been involved in molecular epidemiological studies of gonorrhoea transmission using whole genome sequencing. I am the chair of the writing group of the national HIV post exposure prophylaxis guidelines and more recently conducted a systematic review on HIV transmission of HIV through biting and spitting incidents.