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Dr Richard Stabler

PhD

Associate Professor
in Molecular Bacteriology

Room
Room 362B

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
44 207 927 2824

Fax.
44 207 637 4314

Dr Stablers’ research focus is to understand how and why highly virulent bacteria evolve, in particular in response to the antimicrobial challenge. His focus has been nosocomial pathogens especially those are very much in the public and political eye for example Clostridium difficile and MRSA. More recently he has been focused on Acinetobacter baumannii, the human pathogen declared the highest priority by the WHO in 2017. A. baumannii has evolved to be extremely drug resistant with few treatment options in HIC countries and a far worse situation in LMIC countries. He has been using high throughput sequencing technologies to understand the A. baumannii epidemiology and assessing the use of a bacteriophage depolymerase and ajunct antibody therapy as an alternative to antibiotics employing a disarming rather than kill methodology to reduce the selective pressure that drive AMR.

 

He is a co-investigator on a £20M BBSRC Interdisciplinary one health poultry hub. The hub focuses on achieving sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. He is focusing on transmission of the zoonotic pathogen Campylobacter jejuni from introduction to broiler and egg laying chickens, through the production chain and ultimately to resultant clinical infection. The aim is to identify hotspots of infection, to develop and target intervention strategies, to reduce the burden of disease in LMIC countries. Additionally, the project will be looking at the over use of antimicrobials in food production and investigate the resultant resistance and to look at alternatives from food additives to biosecurity. Additionally, he is funded through the CGIAR IHH project to investigate the presence, transmission and antibiotic resistance of non-typhoidal Salmonella in the Vietnamese pig production value chain.

 

He has developed links with scientists outside my direct sphere, developing interdisciplinarity into my research and have now published and received funding involving, for example, social scientists, modelers, epidemiologists and health policy scientists. He has formed a partnership with a South Korean engineer to develop a nanofluidic microPCR origami point-of-care device to detect A. baumannii and carbapenemase resistance. He is a part of an MRC Joint Health Systems Research Initiative funded team using a multi-stakeholder approach towards operationalising antibiotic stewardship in India's pluralistic rural health system. This social science-led project will generate evidence on developing and operationalising an antibiotic stewardship programme to inform strategies for regulating and improving the performance of informal providers in India.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Antimicrobial Resistance Centre (AMR)

Teaching

Course Director for the MSc Medicial Microbiology

Module Organiser for Core Bacteriology and Clinical Bacteriology

Dept Organiser for Clinical Bacteriology 1 & 2

Research

Research interests include

i) Clostridium difficile: molecular epidemiology and emergence of hypervirulent isolates.

ii) Methicillin resistant Staphylococcus areus: molecular epidemiology and drug resistance

iii) Campylobacter jejuni: molecular epidemiology and identification of source specific markers.

iv) Escherichia coli K1: Analysis of interaction with and role of gut flora in disease process.

v) Development of drug resistance in Acinetobacter baumannii

vi) Development of drug resistance in Neisseria gonorrhoea

Research Area
Bacteria
Diagnostics
Discipline
Genetic epidemiology
Genomics
Molecular epidemiology
Bacteriology
Genetics
Microbiology
Molecular biology
Pathology
Disease and Health Conditions
Diarrhoeal diseases
Infectious disease
Country
Australia
Brazil
United Kingdom
India
Netherlands
Singapore
United States of America
Vietnam
Region
East Asia & Pacific (all income levels)
Euro area
Latin America & Caribbean (all income levels)
North America

Selected Publications

Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review protocol.
Bhate K; Lin L-Y; Barbieri J; Leyrat C; Hopkins S; Stabler R; Shallcross L; Smeeth L; Francis NA; Mathur R
2020
BMJ open
Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study.
Doyle RM; O'Sullivan DM; Aller SD; Bruchmann S; Clark T; Coello Pelegrin A; Cormican M; Diez Benavente E; Ellington MJ; McGrath E
2020
Microbial Genomics
Genomic and Phenotypic Analyses of Acinetobacter baumannii Isolates From Three Tertiary Care Hospitals in Thailand.
Loraine J; Heinz E; Soontarach R; Blackwell GA; Stabler RA; Voravuthikunchai SP; Srimanote P; Kiratisin P; Thomson NR; Taylor PW
2020
FRONTIERS IN MICROBIOLOGY
Ethnically diverse urban transmission networks of Neisseria gonorrhoeae without evidence of HIV serosorting.
Dave J; Paul J; Pasvol TJ; Williams A; Warburton F; Cole K; Miari VF; Stabler R; Eyre DW
2019
Sexually transmitted infections
Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: An inter-laboratory study
Doyle RM; O'Sullivan DM; Aller SD; Bruchmann S; Clark T; Pelegrin AC; Cormican M; Benavente ED; Ellington MJ; McGrath E
2019
BioRxiv
Genome-wide assessment of antimicrobial tolerance in Yersinia pseudotuberculosis under ciprofloxacin stress.
Willcocks S; Huse KK; Stabler R; Oyston PCF; Scott A; Atkins HS; Wren BW
2019
Microbial genomics
See more Publications