Dr Stephen Cose

PhD

Assistant Professor

in Immunology

Room

MRC/UVRI Uganda Research Unit on AIDS

PO Box 49
51-59 Nakiwogo Road
Entebbe
United Kingdom

Tel.

Office: +256 417 757258; Mob: +256 792 925686

Fax.

+256 414 321137

Obtained PhD in Melbourne, Australia, studying the T cell response to HSV infection in mice. In 2005, following several postdocotoral studies in the UK and USA on T cell memory and migration, I took a lectureship at the University of Bristol where I continued my research on T and B cell migration. In 2009 I took a post as Lecturer in Immunology at the LSHTM, permanently seconded to Uganda. I now live in Entebbe, Uganda and am a Senior Immunologist at the MRC Unit here, and also have an Honorary Senior Lectureship at the Makerere University College of Health Sciences.

Affiliations

Faculty of Infectious and Tropical Diseases

Department of Clinical Research

Centres

Global Non-Communicable Diseases

Tuberculosis (TB) Centre

Teaching

I help teach on the ID213 Infectious Diseases DL module, and also help teach on the East African Diploma in Tropical Medicine & Hygiene Short Course. I also deliver lectures in Immunology at Makerere University and Mulago Hospital in Kampala, Uganda.

In addition, I run two Short Courses in Immunology in Uganda. These are both two week courses, one held in March and one in September every year. The focus of these courses is on the Immunology of Tropical Diseases relevant to Sub-Saharan Africa. Please see our website (http://www.muii.org.ug) for more details.

Research

My research interests are in the Immunology of TB infection. I have several TB projects looking at the role of B cells in TB infection. We have an MRC funded study to look at whether maternal latent TB infection affects the infant response to BCG in Uganda, a setting where BCG has poor efficacy. I also have a Wellcome Trust funded PhD Fellow conducting a clinical trial on the non-specific effects of BCG vaccination in infants.

In addition to these research activities, I am also involved in an EU collaboration called The Schistovac, which aims to find a vaccine candidate for Schistosomiasis.

Research Area

Bacteria

Helminths

T-cell immunology

Immunisation

Neonatal health

Discipline

Immunopathology

Immunology

Disease and Health Conditions

Infectious disease

Tuberculosis

Neglected Tropical Diseases (NTDs)

Respiratory disease

Schistosomiasis

Tropical diseases

Country

Uganda

Region

Sub-Saharan Africa (developing only)

Selected Publications

Effect of Maternal Schistosoma mansoni Infection and Praziquantel Treatment During Pregnancy on Schistosoma mansoni Infection and Immune Responsiveness among Offspring at Age Five Years.

Tweyongyere, R. ; Naniima, P. ; Mawa, P.A. ; Jones, F.M. ; Webb, E.L. ; Cose, S. ; Dunne, D.W. ; Elliott, A.M. ;

PLoS Negl Trop Dis

The immune response to infection.

Cose, S.; Kaleebu, P.; Elliott, AM.; Whittle, H.;

Principles of Medicine in Africa.

Most B cells in non-lymphoid tissues are naïve.

Inman, C.F.; Murray, T.Z.; Bailey, M.; Cose, S.;

Immunol Cell Biol

Determining Mycobacterium tuberculosis Infection among BCG-Immunised Ugandan Children by T-SPOT.TB and Tuberculin Skin Testing.

Nkurunungi, G. ; Lutangira, J.E. ; Lule, S.A. ; Akurut, H. ; Kizindo, R. ; Fitchett, J.R. ; Kizito, D. ; Sebina, I. ; Muhangi, L. ; Webb, E.L. ; Cose, S. ; Elliott, A.M. ;

PLoS One

Long-Lived Memory B-Cell Responses following BCG Vaccination.

Sebina, I. ; Cliff, J.M. ; Smith, S.G. ; Nogaro, S. ; Webb, E.L. ; Riley, E.M. ; Dockrell, H.M. ; Elliott, A.M. ; Hafalla, J.C. ; Cose, S. ;

PLoS One

Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.

Tweyongyere, R. ; Mawa, P.A. ; Kihembo, M. ; Jones, F.M. ; Webb, E.L. ; Cose, S. ; Dunne, D.W. ; Vennervald, B.J. ; Elliott, A.M. ;

BMC Infect Dis

Memory versus naive T-cell migration.

Lewis, M. ; Tarlton, J.F. ; Cose, S. ;