Explore more Centres, Projects and Groups
Welcome Banner
@NEST360 Malawi Hospital

IMPRESS: Innovative Management PRactices to Enhance hoSpital quality and Save lives in Malawi

Examining whether enhanced hospital management practices can drive improvements in newborn survival and the quality of clinical care in Malawi

Bottom Content

IMPRESS (Innovative Management PRactices to Enhance hoSpital quality and Save lives in Malawi) focuses on hospital management in Malawi. Building on an existing platform, Newborn Essential Solutions & Technologies (NEST360), we are identifying practical ways to enhance management practices in hospitals in Malawi, to improve quality of care and reduce newborn deaths. We are also strengthening the capacity and capability of the next generation of health systems researchers.

This is a four-year NIHR-funded project that started in October 2020. At the core of the research is an equitable partnership between College of Medicine, University of Malawi and London School of Hygiene & Tropical Medicine. We are working with the Ministry of Health and other stakeholders to generate high quality evidence that has direct relevance for policy and practice in Malawi, the African region, and beyond.


We are a multi-disciplinary team of health system researchers, epidemiologists, health economists, social scientists, clinicians, implementation scientists and statisticians.

We are addressing what are three fundamental gaps in knowledge. First, until recently, we did not have the tools to measure the hospital adoption modern management practices. Building on recent advances, we are adapting and validating tools to Malawi to measure management practices. Second, no interventions to enhance hospital management practices have been rigorously evaluated. Working in partnership with the Ministry of Health, experts and other key partners, we are co-designing a management intervention with a view to evaluating it in a randomised controlled trial and other complementary methods. Third, it is rarely possible to measure lives saved in such health systems research.

By building on the existing NEST360 network of 36 hospitals with detailed patient level information on newborns admitted to hospital, we are examining which management practices matter most for quality of care.

Capacity strengthening

We strengthen research capacity through formal postgraduate training (PhD and MSc), mutual learning during the research, skills training, and mentorship.  

About IMPRESS 2 columns
About IMPRESS 2 columns left paragraph

Project rationale

Every year 2.5 million newborns die. Most of these deaths happen in hospital and could be prevented. Babies in their first 28 days of life represent some of the most vulnerable users of the health system, as they can die quickly. Malawi has been one of the fastest progressing countries in Africa for newborn survival. Now that most births happen in health facilities, there is an urgent need to improve hospital care for newborns and their families.

Health technologies and skilled clinical staff are a necessary ingredient for improving survival of small and sick babies. However, in practice, babies do not always get these clinical interventions even when resources are available. Commonplace problems, such as drug stockouts, absent staff, and power outages, may be due to organisational failings that are rooted in poor management. Improving management practices – so that hospitals effectively manage staff, drugs and medical supplies, have sound financial management and are data-driven in how they make decisions – offers the potential to turn the situation around.

Recent studies indicate that management practices – in the areas of human resource management, performance monitoring, target setting and operations – may be a driver of quality care but there are few relevant studies in low- and middle-income settings, especially ones with enough data on patient mortality.


Building on an existing platform, Newborn Essential Solutions & Technologies (NEST360), we are identifying practical ways to enhance management practices in hospitals in Malawi. IMPRESS aims to examine whether enhanced management practices can improve health outcomes and clinical quality for newborns in hospitals. A multi-disciplinary team from College of Medicine and LSHTM will address the following main objectives:

  1. Adapt and validate measures of hospital and district management practices
  2. Examine the association between management practices and quality of clinical care, and its variation by facility characteristics
  3. Co-design a problem-focused hospital management intervention and scalable delivery model
  4. Evaluate effectiveness of the intervention on neonatal mortality and secondary outcomes (including hospital-acquired infections) through a cluster randomised trial
  5. Assess the intervention’s acceptability, fidelity, and mechanisms through multi-methods research and estimate its cost-effectiveness

Capacity strengthening

IMPRESS will generate novel evidence on hospital management practices, with two-way skills transfer between the UK and Malawi, strengthening capacity of health systems researchers, hospital staff and district health officials. We strengthen research capacity through formal postgraduate training (PhD and MSc), mutual learning during the research, skills training, and mentorship.


IMPRESS is a collaboration between the College of Medicine, University of Malawi and London School of Hygiene & Tropical Medicine. We are working in close partnership with NEST360, the Government of Malawi’s Ministry of Health, and other stakeholders to inform policy to the benefit of neonates at high risk in Malawi, and beyond.

We work closely with LSHTM’s Centre for Health Economics in London and the Centre for Maternal, Adolescent, Reproductive, & Child Health.


Ensuring that the study findings have maximum impact is given high priority by all partners in the research team. The planned outputs from the research include:

  • Validated tools to measure management practices at the hospital and district level
  • Novel data on the extent to which hospitals adopt management practices and evidence on which practices matter for quality
  • Co-designed hospital management intervention based on a well-articulated theory of change and developed with scalability in mind
  • Rigorous evidence in a low income setting on the effectiveness of a hospital intervention to improve management practices, quality of care and patient outcomes
  • Process findings on implementation, mechanisms, context and costs, to inform scale-up and generalisability to other countries
  • Capacity strengthening of a cadre of management trainers with capability to scale up intervention, hospital clinicians and managers, and health system researchers

We focus on four key groups of users. In addition, as these groups act on the research findings, there is clear potential for neonates to benefit from improved quality of care in hospitals across the whole of Malawi:

  • National stakeholders. They include national and district government bodies, professional associations and NGOs
  • Hospital managers and clinicians. We are engaging early with this key group of users through zonal sensitisation workshops to maximise ownership and input into the design
  • International funders. We are leveraging our long-standing relationships with international stakeholders and we will coordinate closely with NEST360 in communicating findings through its network in Kenya, Tanzania, and Nigeria
  • Academic community. We aim to publish in a range of academic journals and are committed to ensuring open access. We will present findings at conferences and via webinars


This project (NIHR131237) is funded by the National Institute for Health Research (NIHR) using UK aid from the UK Government to support global health research. The views expressed on the website are those of the author(s) and not necessarily those of the NIHR or the UK Government.

Research IMPRESS 2 columns
Research IMPRESS 2 columns left paragraph

A multi-disciplinary team from the College of Medicine, University of Malawi and LSHTM will address the following interlinked objectives (click on each one for more information):

1) To adapt and validate measures of hospital and district management practices

Formative qualitative research and psychometric performance assessment will generate validated tools to measure management practices.

This objective falls under the formative phase of research. We first identify and describe the types of management-related practices in hospitals and district health offices that may affect the quality of clinical care. Through in-depth interviews with hospital managers, clinicians and district health officials, we are exploring their understanding of what good management looks like in their setting, what practices are expected and implemented, perceptions of what management practices are important for supporting the provision of clinical care, and the attributes of effective leadership in a hospital setting.

An important part of the formative phase is to theorize how management practices may affect quality of care. Here we draw on causal loop diagrams, which are ideal for providing a blueprint for complex systems by representing important, non-linear feedback and relationships that further our understanding of how these systems operate. We undertake “group model building” sessions involving doctors, nurses and managers to map out – with the help of a causal loop diagram – the management-related causes of poor quality of care in the hospital.

Informed by these data and a review of existing instruments, we develop and implement a new survey tool to quantitatively measure the adoption of management practices in 36 hospitals. The survey includes a combination of interview with hospital managers, direct observation, and review of facility records. Using the cross-sectional survey data on management practices collected in the hospitals, we use psychometric methods to assess the acceptability, reliability and validity of the tool.

2) To examine the association between management practices and quality of clinical care

Data on management practices linked to patient level measures of clinical quality will provide observational evidence on which practices matter for quality.

This objective examines the association between hospital management practices and clinical quality, and its variation by facility characteristics. Study outcomes include neonatal outcomes, such as all cause in-hospital mortality, and clinical care processes for newborns, such as adherence to essential interventions for sick babies. The observational study makes use of the cross-sectional data on management practices collected in the first objective and links to these to the NEST360 patient level data. The latter is a de-identified prospective dataset on every newborn admitted to a newborn care unit in study hospitals containing information on the newborn’s admission status, maternal, birth and infant details, observations and nursing care, microbiology and labs, interventions and discharge outcome.

Analyses examine associations of hospital and district management scores with clinical quality. The primary outcome is all cause in-hospital mortality. Secondary outcomes are: birth weight standardized mortality, adherence to essential interventions for sick newborns (e.g. neonates <2500g who get kangaroo mother care); and neonates with hospital-acquired infections. further analyses explore the relative importance of individual management practices and sub-group differences with respect to hospital sector and level.

3) To co-design a problem-focused hospital management intervention and scalable delivery model

Stakeholder workshops that draw in national and international expertise will result in a theory-driven intervention to enhance hospital management practices.

Intervention development follows MRC guidance on complex interventions, including the need to identify relevant literature, develop the intervention around a credible theory of change, and consider implementation at an early stage. The intervention development draws on practical guidance on the importance of middle-level principles (e.g. support factors, derailers, safeguards) and more specific theoretical insights from the quality improvement literature (e.g. lean, six sigma, plan-do-study-act-cycles). It is also informed by early findings from objectives one and two – including the causal loop diagram derived from the model building workshops. We facilitate an inclusive process which brings together key stakeholders to co-design the intervention, including the Ministry of Health’s Quality Management Directorate, hospital managers and neonatal unit clinicians, and parent and community representatives. The output from this process is a co-designed hospital management intervention that is based on a well-articulated theory of change, thickened with information about the local setting in Malawi, and developed with scalability in mind.

4) To evaluate effectiveness of hospital management intervention on neonatal mortality and secondary outcomes (including hospital acquired infections)

A cluster RCT will generate evidence on the effects of enhancing hospital management practices on patient outcomes and clinical quality.

We evaluate the effectiveness of the hospital management intervention on neonatal mortality and secondary outcomes through a cluster randomised controlled trial. Since NEST360 is being implemented in all the study hospitals, we are testing the hypothesis that resources (medical devices, clinical training, quality improvement visits) in combination with supportive management practices can improve quality. The study outcomes include in-hospital mortality of newborn admissions (primary) and secondary outcome measures of clinical quality and uptake of management practices.

5) To assess acceptability, fidelity, and mechanisms of effect and estimate cost-effectiveness

A process evaluation and cost-effectiveness analysis will inform scale-up in Malawi and generalisability of the trial findings to other countries.

We conduct a process evaluation based on MRC guidance on complex interventions and realist evaluation principles, to address the following questions. Is the intervention implemented as intended? Is it acceptable to hospital staff? Do the mechanisms that underpin the intervention work, and if not, why not? How does context affect the success or failure of the intervention? Is it value for money? The process evaluation – particularly the focus on mechanisms – will be guided by the theory of change developed in the third objective. We draw on in-depth interviews, routine programme data and economic cost data. 


Capacity strengthening
Capacity strengthening IMPRESS 2 columns
Capacity strengthening IMPRESS 2 columns left paragraph

The IMPRESS team see mutual capacity strengthening as vital for a successful collaboration, and a key foundation of an equitable partnership, building on the strong traditions of College of Medicine and LSHTM in this area.

We aim to strengthen capacity and capability at both the individual and institutional level, with a view to enhancing IMPRESS research, its communication and policy impact, and the long-term futures of the individuals and institutions involved.

Our capacity strengthening strategies based on the following principles:

  • The strategy is developed collaboratively across the team
  • It covers individual researchers at all levels, team administrators, our research organisations and, where appropriate, our policy and implementation partners
  • It is informed by systematic needs assessments
  • Opportunities are allocated in a transparent and equitable manner
  • We emphasise opportunities for mutual learning across the team
  • We monitor and evaluate our progress

The scope of our capacity development activities includes (i) formal post-graduate training; (ii) knowledge exchange during regular meetings and workshops; (iii) mentoring; and (iv) targeted training sessions. We follow these five key stages:

Flowchart showing IMPRESS five stages of capacity development activities


Team Block


Associate Professor


College of Medicine, University of Malawi
Victor Mwapasa

Victor Mwapasa

Professor of Epidemiology and Public Health
Linda Nyondo-Mipando

Linda Nyondo-Mipando

Lecturer in health Systems and Policy
Queen Dube

Queen Dube

Professor & Head of Department of Pediatrics at Queen Elizabeth Central Hospital
Publications IMPRESS 2 columns
Publications IMPRESS 2 columns left paragraph

Project publications

Coming soon. 

Related publications

Powell-Jackson T, Purohit B, Saxena D, Golechha M, Fabbri C, Ganguly PS, Hanson K. Measuring management practices in India's district public health bureaucracy. Soc Sci Med. 2019 Jan;220:292-300.

Rao SPN, Minckas N, Medvedev MM, Gathara D, …Lawn JE; COVID-19 Small and Sick Newborn Care Collaborative Group. Small and sick newborn care during the COVID-19 pandemic: global survey and thematic analysis of healthcare providers' voices and experiences. BMJ Glob Health. 2021 Mar;6(3):e004347. doi: 10.1136/bmjgh-2020-004347. PMID: 33716220.

Minckas N, Medvedev MM, Adejuyigbe EA, …Lawn JE; COVID-19 Small and Sick Newborn Care Collaborative Group. Preterm care during the COVID-19 pandemic: A comparative risk analysis of neonatal deaths averted by kangaroo mother care versus mortality due to SARS-CoV-2 infection. EClinicalMedicine. 2021 Feb 15;33:100733.