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Mr Luke Vale

Professor of Health Economics

United Kingdom

I am a researcher with an international reputation in economic evaluation and health technology assessment and have contributed significantly to the growth in the use of systematic reviews and economic modelling in this field. This expertise is built on nearly 30 years of health economics experience. I am currently a Professor of Health Economics which I joined in 2023. I am a member and health economics lead for the NICE funded Newcastle External Assessment Centre and lead health economist for the NIHR Behavioural Science Policy Research Unit. I am chair of the Executive of the NIHR research Support Service for the North East and North Cumbria,

Prior to joining LSHTM I led the Health Economics Group at Newcastle University. I was also Director of the NIHR funded Newcastle Technology Assessment Review Centre and collaborator and theme lead for the Enabling Methodologies Theme of the NIHR Applied Research Collaboration and collaborator and lead health economist on other NIHR infrastructure including the NIHR Newcastle In Vitro Diagnostics Co-operative, Patient Safety Research Collaboration and the Blood and Transplant research Unit .

Until 2023 I was co-ordinating editor of the NIHR funded Cochrane Incontinence Review Group and following reorganisation of Cochrane I remain as a sign-off editor. I was also Chair from 2010 to 2020 of the joint economic methods group of the international Cochrane and Campbell Collaborations (http://methods.cochrane.org/economics/) which develops the methods and conducts systematic reviews of interventions in health care and other policy areas; I am still actively developing methodology in this area.

I have considerable managerial and supervisory experience including most recently as the Deputy Director of the Institute of Health & Society at Newcastle University (until 2019). I also have a proven record in attracting research funds, completing projects to a high standard and in a timely fashion. I have extensive links with policy makers and researchers throughout the UK and internationally and was economic advisor the recent Topol review on digital medicine. The total value of competitive peer reviewed funding I have been awarded is in excess £165 million including a substantial number as Principal Investigator. In addition, I have a strong publication record with well over 400 papers in peer-reviewed journals, 4 books, 15 book chapters and over 100 other significant reports.

Affiliations

Department of Health Services Research and Policy
Faculty of Public Health and Policy

Teaching

My main areas of teaching focus on the methods and application of economic evaluation in health care. This includes development of short courses on aspects of economic evaluation and health technology assessment for different groups nationally and internationally.

Research

Key research interests are:

Economic evaluation as part of randomised controlled trials and Health Technology Assessments for national and international agencies

Use of economic evaluation techniques in the design of complex interventions and health technologies

Development of methods for the incorporation of discrete choice experiments and willingness to pay estimates into economic evaluation

Identification and exploration of methods to improve the efficiency of economic evaluation research.
Research Area
Health economics
Clinical trials
Systematic reviews
Economic evaluation

Selected Publications

Young People's Valuations of Managing Compromised Molars: A Discrete Choice Experiment.
Taylor, GD; Boyers, D; Exley, C; Innes, N; VALE, L; Vernazza, CR;
2026
JDR clinical and translational research
Community Optometrist-Led Monitoring of Quiescent Neovascular Age-Related Macular Degeneration: The FENETRE Randomized Clinical Trial.
Sharma, A; Jaber, A; Pal, B; Lawrenson, JG; Harper, RA; Tufail, A; Learoyd, AE; Robinson, E; Douiri, A; Burman, R; Kernohan, A; Vougioukalou, S; Read, S; Csontos, J; Jones, A; Mahmood, S; McKibbin, M; Peacock, JL; Gale, R; Patel, PJ; Keane, PA; Hamilton, R; VALE, L; Bunce, C; Balaskas, K;
2026
JAMA network open
PARTIAL: study protocol for a clinical and cost-effectiveness of complex PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma randomised trial.
Johnson, D; Thomas, R; Cotton, S; Newlands, R; Cooper, D; McCann, S; VALE, L; Gillies, K; Bex, A; Challacombe, B; Falloon, J; MacLennan, G; Narahari, K; Nicol, D; Sheerin, N; Stewart, GD; Tran, M; Heer, R; Soomro, N;
2026
Trials
Evaluation of non-ophthalmologist-led and offline AI-assisted models for diabetic retinopathy screening in India: a pragmatic diagnostic accuracy study.
Chauhan, A; VALE, L; Kankaria, A; Tigari, B; Kumar, S; Yadav, M; Kumar, L; Kaur, G; Bhadada, SK; Gupta, V; Duggal, M;
2026
BMJ open
Seizure prophylaxis in glioma surgery: a synopsis from the SPRING RCT.
Jenkinson, MD; Bulbeck, H; Carruthers, J; Burns, J; Lessels, S; Dobbie, R; Watson, R; Gribben, C; Rooney, AG; Thompson, G; Robinson, T; VALE, L; Erridge, S; Watts, C; Marson, AG; Grant, R; SPRING Study Collaborators,;
2026
Health technology assessment (Winchester, England)
Clinical and cost-effectiveness of eculizumab withdrawal in atypical haemolytic uraemic syndrome: the SETS aHUS multi-centre, open-label, prospective and single-arm study.
Bryant, A; Lecouturier, J; Orozco-Leal, G; Brocklebank, V; Carnell, S; Chadwick, TJ; Dunn, S; Johnson, SA; Kavanagh, D; Kennedy, CA; Malina, M; Montgomery, EK; Muirhead, CR; Oluboyede, Y; VALE, L; Weetman, C; Kwan Soon Wong, E; Woodward, L; Sheerin, NS;
2026
Health technology assessment (Winchester, England)
Surgery versus conservative management for severe pectus excavatum (RESTORE): protocol for a multicentre, randomised, controlled superiority trial.
Maier, R; Dunning, J; Wason, J; Chadwick, T; Bryant, A; Fernandez-Garcia, C; VALE, L; Danjoux, GR; Wallace, G; Levett-Renton, A; Naidu, B; Pryor, C; McCulloch, P; Thursfield, R; Wyllie, J; Chang, L; Marsay, L; Akowuah, E;
2025
BMJ open
Subjective Evaluation of Female Adult Body Fat Distribution: A Scoping Review.
Lennie, SC; Hall, A; Nguyen, G; Boath, A; VALE, L; Teare, MD; Heslehurst, N;
2025
Obesity reviews : an official journal of the International Association for the Study of Obesity
Outlook for life sciences in the UK.
Katikireddi, SV; VALE, L;
2025
BMJ (Clinical research ed.)
Tele-ophthalmology-enabled and artificial intelligence-ready referral pathway for community optometry referrals of retinal disease: HERMES cluster randomised trial with a diagnostic accuracy study.
Sharma, A; Hussain, R; Learoyd, AE; Aristidou, A; Soomro, T; Blandford, A; Lawrenson, JG; Grimaldi, G; Douiri, A; Kernohan, A; Robinson, T; Moradi, N; Dinah, C; Minos, E; Sim, D; Aslam, T; Manna, A; Denniston, AK; Patel, PJ; Keane, PA; BUNCE, C; VALE, L; Balaskas, K;
2025
Health technology assessment
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