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Professor Caroline Relton

Pro-Director Research and Academic Development

United Kingdom

I am Pro Director for Research and Academic Development at LSHTM. As a member of the Executive Team my responsibilities include oversight of research, innovation and impact strategy, research culture, governance and integrity, partnerships, the Doctoral College, inter-disciplinary Centres and academic development (career development and promotions).

My research interests lie in investigating the role of epigenetics in development and disease and the use of epigenetic biomarkers in applied health contexts.

 

I am Emeritus Professor of Epigenetic Epidemiology at the University of Bristol.

Affiliations

Executive Office

Teaching

I have experience of designing and teaching undergraduate, Master's and short course programmes, mainly in the field of Molecular Epidemiology. I act as a visiting lecturer on various taught programmes.

Research

My research interests are in genetic and epigenetic epidemiology. My work has involved both methodological development and applied research, with the aim of seeking to understand the role of DNA methylation in common complex disease. I have investigated the role of common genetic variation in determining DNA methylation variation and used genotype to explore causal pathways via molecular mediation. I have also studied the use of DNA methylation, as well as other molecular phenotypes, in disease prediction, prognosis and patient stratification.

 

My current work focuses on the use of DNA methylation biomarkers as indices of common risk factors (smoking, age, inflammation, adiposity, etc.) and their application in risk stratification and is funded by Cancer Research UK. 

 

Research Area
Genetic epidemiology
Molecular epidemiology
Disease and Health Conditions
Cancer
Obesity
Mental health
Cardiovascular diseases
Country
India
Gambia
United States of America
Canada
Norway
Netherlands
France

Selected Publications

Breastfeeding association with DNA methylation in the pregnancy and childhood epigenetics (PACE) consortium.
Caramaschi, D; Fernández-Barrés, S; Casey, E; Cruells, A; Czamara, D; Sharkawy, ME; Elliott, HR; Fore, R; Gairola, R; Gruzieva, O; Huels, A; Lahti, J; Lee, H; Magnano San Lio, R; Malmberg, A; Mansell, T; Merid, SK; Novakovic, B; Ott, R; Pelegrí, D; Rezwan, FI; Rifas-Shiman, SL; Weiss, A; De Lauzon-Guillain, B; Duijts, L; ... Bustamante, M.
2026
Clinical epigenetics
An epigenome-wide analysis of DNA methylation, racialized and economic inequities, and air pollution
Watkins, SH; Testa, C; Simpkin, AJ; Smith, GD; Coull, B; De Vivo, I; Tilling, K; Waterman, PD; Chen, JT; Diez-Roux, AV; Krieger, N; Suderman, M; RELTON, CL;
2026
Figshare
DNA methylation-based clocks, tobacco smoking, and lung cancer risk.
Penha, RC C; Onwuka, JU; Langdon, R; Sandanger, TM; Nøst, TH; Vineis, P; Johansson, M; Milne, RL; Dugué, P-A; RELTON, C; Suderman, M; McKay, J; Johansson, M;
2025
BMC medicine
An epigenome-wide analysis of DNA methylation, racialized and economic inequities, and air pollution.
Watkins, SH; Testa, C; Simpkin, AJ; Smith, GD; Coull, B; De Vivo, I; Tilling, K; Waterman, PD; Chen, JT; Diez-Roux, AV; Krieger, N; Suderman, M; RELTON, C;
2025
Clinical epigenetics
Cell type-specific methylome-wide association studies of childhood ADHD symptoms.
Meijer, M; Klein, M; Caramaschi, D; Clark, SL; Cosin-Tomas, M; Koen, N; Lu, X; Mulder, RH; Röder, SW; Zhang, Y; Zilich, L; Bustamente, M; Deuschle, M; Felix, JF; González, JR; Gražulevičiene, R; Streit, F; Wright, J; Carracedo, A; Cecil, CA M; Corpeleijn, E; Hartman, CA; Herberth, G; Huels, A; RELTON, C; ... Van den Oord, EJ C G.
2025
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study.
Morales Berstein, F; Khouja, J; Gormley, M; Ebrahimi, E; Virani, S; McKay, JD; Brennan, P; Richardson, TG; RELTON, CL; Davey Smith, G; Borges, MC; Dudding, T; Richmond, RC;
2025
eLife
Differential DNA methylation patterns in whole blood from ACPA-positive patients with DMARD-naïve rheumatoid arthritis at clinical disease onset.
Svendsen, AJ; Mengel-From, J; Junker, P; Dalgård, C; Davey Smith, G; RELTON, CL; Elliott, HR; Kyvik, K; Lindegaard, H; Christensen, AF; Tan, Q;
2025
Frontiers in Immunology
Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study.
Morales-Berstein, F; Khouja, J; Gormley, M; Ebrahimi, E; Virani, S; McKay, J; Brennan, P; Richardson, TG; RELTON, CL; Smith, GD; Borges, MC; Dudding, T; Richmond, RC;
2025
medRxiv
Epigenetic markers of adverse lifestyle identified among evening and night shift workers in two UK population-based studies: Generation Scotland and Understanding Society.
Hulls, PM; McCartney, DL; Bao, Y; Walker, RM; De Vocht, F; Martin, RM; RELTON, CL; Evans, KL; Kumari, M; Marioni, RE; Richmond, RC;
2025
Chronobiology international
Place-based household vouchers for locally supplied fruit and vegetables: the Fresh Street pilot cluster randomised controlled trial.
RELTON, C; Blake, MK; Bridge, G; Umney, D; Taylor, SJ C; Adams, J; Mihaylova, B; Griffiths, C; Hooper, R; Phillips, R; Palmer, L; Gamston, A; Williamson, K;
2025
BMC public health
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