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Dr Jayne Ellis

Clinical Assistant Professor - NIHR Academic Clinical Lecturer

United Kingdom

Jump to: Affiliations Research Publications

I am a Infectious Diseases and Microbiology clinician and a Clinical Assistant Professor/NIHR Academic Clinical Lecturer with the London School of Hygiene and Tropical Medicine. 

I am currently working in London and at the Infectious Diseases Institute (IDI) in Kampala where I work as part of an Advanced HIV disease research group conducting observational studies and RCTs aimed at improving the diagnosis, prevention and management of opportunistic infections (OIs) amongst hospitalised adults living with HIV. I have a particular interest in HIV-associated neurological infections (cryptococcal meningitis, and TB meningitis).

Affiliations
Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Research

My research interests are focussed on improving outcomes for adults living with advanced HIV disease, particularly within the inpatient setting. We are conducting a number of clinical studies with the aim of improving the diagnosis, management and prevention of key opportunistic infections (TB, blood stream infection and cytomegalovirus) through use of screening bundles and novel diagnostics.

I was PI of the I now completed IMPROVE RCT: Integrated management of cryptococcal meningitis and concurrent opportunistic infections to improve outcomes in advanced HIV disease - a strategy RCT to investigate the optimal strategy for ultra short course (1HP) TB preventive therapy for adults with advanced HIV disease and cryptococcal meningitis.

 

I am the Ugandan co-PI of the NIRVANA study: ValgaNciclovIR for CMV Viraemia in AdvaNced HIV disease: A phase 2b Randomised Placebo Controlled Trial of Valganciclovir for Cytomegalovirus Viraemia in Adults and adolescents with Advanced HIV Disease.

Selected Publications
Once-Daily Dolutegravir-Based Antiretroviral Therapy Among Adults With Advanced HIV Disease Receiving 1 Month of Daily Rifapentine and Isoniazid for Tuberculosis-Preventive Therapy and Fluconazole for Treatment of Cryptococcal Meningitis: Results of a Pharmacokinetic Study.
ELLIS, J; HALE, G; Buzibye, A; Omali, D; Naluyima, S; Ntenkaire, N; Nsangi, LJ; Ndyetukira, JF; Sadiq, A; Ahimbisibwe, C; Nabbaale, S; Tukundane, A; Bakka, W; Gakuru, J; Kawuma, AN; Cresswell, FV; MOORE, DA J; Meya, DB; Boulware, DR; Waitt, C; JARVIS, JN; Nicol, MR;
2026
Open forum infectious diseases
Central Nervous System Toxoplasmosis is an Under-Recognized Opportunistic infection in Uganda.
Bahr, NC; Kasibante, J; Nsangi, L; Kagimu, E; Ssebambulidde, K; Rutakingirwa, MK; Tugume, L; Ramachandran, PS; Cresswell, F; Meya, DB; Boulware, DR; Wilson, MR; ELLIS, J;
2026
Journal of tropical medicine
Cytomegalovirus viremia in advanced HIV disease.
ELLIS, J; JARVIS, JN;
2026
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Ophthalmic features of HIV associated cryptococcal meningitis in Malawian Adults: an observational study.
ELLIS, JP; Gaskell, K; Peirse, M; Gormley, J; Kalata, N; Burgess, PI; Mopamboli, P; Manda, CA; Kiire, CA; Maccormick, I; Gondwe, E; Molloy, SF; Harrison, TS; Lalloo, DG; Heyderman, RS;
2026
Wellcome open research
Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study.
Nsangi, L; HALE, G; Dai, B; Hullsiek, KH; Tukundane, A; Namudde, A; Menya, GB; Ayebare, P; Nankungu, L; Namuju, OC; Mulwana, S; Kabahubya, M; Meya, DB; Boulware, DR; CRESSWELL, FV; Bahr, NC; Abassi, M; ELLIS, J;
2026
Open forum infectious diseases
Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial.
ELLIS, J; HALE, G; Nsangi, LJ; Wele, A; Kigozi, E; Gakuru, J; Kagimu, E; Mugabi, T; Namombwe, S; Kimuda, S; Ssekindi, F; Ndyetukira, JF; Sadiq, A; Tukundane, A; Bakka, W; Harrison, TS; Mande, E; Muzoora, C; MOORE, DA J; Meya, DB; Fielding, K; Boulware, DR; JARVIS, JN;
2026
The lancet. HIV
Ophthalmic features of HIV associated cryptococcal meningitis in Malawian Adults: an observational study
ELLIS, J; Gaskell, K; Peirse, M; Gormley, J; Kalata, N; Burgess, P; Mopamboli, P; Manda, C; Kiire, C; Maccormick, I; Gondwe, E; Molloy, S; Harrison, T; Lalloo, D; Heyderman, R;
2026
Wellcome Open Res
Valganciclovir for cytomegalovirus viraemia in advanced HIV disease: a phase 2b randomized placebo-controlled trial of valganciclovir for cytomegalovirus viraemia in adults and adolescents with advanced HIV disease.
ELLIS, J; Nsangi, LJ; Rassool, M; Musaazi, J; LAWRENCE, DS; Skipper, C; Boulware, DR; Meya, DB; Wasserman, S; JARVIS, JN; Boyles, T;
2025
Philos Trans R Soc Lond B Biol Sci
Epstein-Barr Virus Central Nervous System Infections and Mortality Risk in Patients Presenting With Suspected Meningitis: Results From the Botswana National Meningitis Survey and the Harare Meningitis Aetiology Study.
ELLIS, J; Milburn, J; Ngoni, K; Williams, CG; Muthoga, C; Mwarumba, T; Gwakuba, E; Manenji, G; Suresh, R; Machiya, T; Thubuka, J; Northcott, C; Penney, J; Kinsella, M; Mechie, I; Ensor, S; Leeme, T; Owen, L; Barton, H; Siamisang, K; Tenforde, MW; Hurt, W; Doyle, R; GRINT, D; Molloy, SF; ... JARVIS, JN.
2025
Open forum infectious diseases
Epstein-Barr virus and cytomegalovirus co-infections and mortality risk in patients with HIV-associated cryptococcal meningitis: a post-hoc analysis of a prospective nested cohort in the AMBITION-cm randomised controlled trial.
ELLIS, J; Groppelli, E; Doyle, R; LAWRENCE, DS; Meya, DB; Boulware, DR; Mwandumba, HC; Kanyama, C; Hosseinipour, MC; Meintjes, G; Muzoora, C; Mosepele, M; Ndhlovu, CE; Harrison, TS; JARVIS, JN; AMBITION Study Group,;
2025
The Lancet HIV
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Jayne Ellis

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United Kingdom