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Dr Rachael Burke

Clinical Assistant Professor

United Kingdom

I am an NIHR Assistant Professor, combing NHS work as an Infectious Disease and General (Internal) Medicine specialist registrar with work as an academic at the school.  I work on clinical epidemiology related to TB and HIV. 

 

I previously lived and worked in Malawi (when doing my Wellcome-funded clinical PhD), but am now London-based.  I work closely with Prof Peter MacPherson (now at Glasgow University) and Prof Liz Corbett (at the school), among others.  I am member of the LSHTM TB Centre.

 

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am the co-module organiser (with Prof Liz Corbett) on the TB module in the MSc Infectious Disease.

Research

I have worked on community, primary care and hospital level studies: including TB Active Case Finding and diagnostic studies, but I have a particular interest in Advanced HIV Disease and reducing mortality among people living with HIV admitted to hospital. 

 

I was PI of the CASTLE trial about enhanced TB diagnostics (Computer Aided Diagnosis chest X-ray and urine LAM testing), and am co-PI of the SaDAPT trial (Same Day ART in Presumptive TB) with colleagues in Lesotho, Malawi and Switzerland.

 

I also experience doing various systematic reviews related to TB and HIV, and being an expert contributor to several WHO guideline develop processes.

Selected Publications

Same-day versus rapid ART initiation in people with HIV and symptoms of tuberculosis (SaDAPT): a randomised, non-inferiority trial in Lesotho and Malawi.
Gerber, F; Semphere, R; Lukau, B; Mahlatsi, P; Mbale, H; Sanchez-Samaniego, G; Sass, N; Amstutz, A; Molatelle, M; Marake, NB; Tarumbiswa, T; Nliwasa, M; Ayakaka, I; Glass, TR; MacPherson, P; BURKE, RM; Labhardt, ND;
2026
The lancet. HIV
Deidentified individual-level data used in "Distribution and transmission of M. tuberculosis in a high-HIV prevalence city in Malawi: A genomic and spatial analysis"
Chitwood, MH; CORBETT, EL; Ndhlovu, V; Sobkowiak, B; Colijn, C; Andrews, JR; BURKE, RM; Cudahy, PG T; Dodd, PJ; Imai-Eaton, JW; Engelthaler, DM; Folkerts, M; Feasey, HR A; Lan, Y; Lewis, J; McNichol, J; Menzies, NA; Chipungu, G; Nliwasa, M; Weinberger, DM; Warren, JL; Salomon, JA; MacPherson, P; Cohen, T;
2025
PLOS Global Public Health
Distribution and transmission of M. tuberculosis in a high-HIV prevalence city in Malawi: A genomic and spatial analysis.
Chitwood, MH; CORBETT, EL; Ndhlovu, V; Sobkowiak, B; Colijn, C; Andrews, JR; BURKE, RM; Cudahy, PG T; Dodd, PJ; Imai-Eaton, JW; Engelthaler, DM; Folkerts, M; Feasey, HR A; Lan, Y; Lewis, J; McNichol, J; Menzies, NA; Chipungu, G; Nliwasa, M; Weinberger, DM; Warren, JL; Salomon, JA; MacPherson, P; Cohen, T;
2025
PLOS global public health
Causes of hospitalisation among people living with HIV worldwide, 2014-23: a systematic review and meta-analysis.
BURKE, RM; Sabet, N; ELLIS, J; Rangaraj, A; LAWRENCE, DS; JARVIS, JN; FALCONER, J; Tugume, L; Bidwell, G; Berhanu, RH; MacPherson, P; Ford, N;
2025
The lancet. HIV
Interventions to Support People With HIV Following Hospital Discharge: A Systematic Review.
Ford, N; Rangaraj, A; JARVIS, JN; LAWRENCE, DS; Chou, R; Kamenshchikova, A; Hargreaves, S; BURKE, RM;
2025
Open forum infectious diseases
Impact of active case finding for tuberculosis with mass chest X-ray screening in Glasgow, Scotland, 1950-1963: An epidemiological analysis of historical data.
MacPherson, P; STAGG, HR; SCHWALB, A; Henderson, H; Taylor, AE; BURKE, RM; RICKMAN, HM; Miller, C; HOUBEN, RM G J; Dodd, PJ; CORBETT, EL;
2024
PLoS medicine
Summary of posterior draws from pulmonary tuberculosis model
MacPherson, P; STAGG, HR; SCHWALB, A; Henderson, H; Taylor, AE; BURKE, RM; RICKMAN, HM; Miller, C; HOUBEN, RM G J; Dodd, PJ; CORBETT, EL;
2024
PLOS Medicine
HIV hospitalisation systematic review data
BURKE, R;
2024
London School of Hygiene & Tropical Medicine
Impact of active case finding for tuberculosis with mass chest X-ray screening in Glasgow, Scotland, 1950-1963: an epidemiological analysis of historical data
MacPherson, P; Stagg, H; SCHWALB, A; Henderson, H; Taylor, A; BURKE, R; RICKMAN, H; Miller, C; Houben, RM G J; Dodd, P; CORBETT, E;
2024
medRxiv
Treatment preferences among people at risk of developing tuberculosis: A discrete choice experiment.
Kamchedzera, W; Quaife, M; Msukwa-Panje, W; BURKE, RM; Macpherson, L; Kumwenda, M; Twabi, HH; Quartagno, M; MacPherson, P; Esmail, H;
2024
PLOS global public health
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