Cholera spread tracked at household level for first time

Nearly 80% of cholera transmission in Dhaka, Bangladesh occurs between people who share a household, according to a new study published in Nature Genetics
Prevent cholera leaflet on noticeboard

Dhaka is a city with a ‘hyper-endemic’ level of cholera. In this large-scale genomic study the researchers tracked transmission of the disease at the household level for the very first time. The results could be used by public health officials to improve cholera control strategies - preventing the chain of transmission within households in high-burden areas could have a huge impact on reducing the number of cholera cases worldwide.

Led by the Wellcome Sanger Institute, the research team included Nick Thomson, Professor of Bacterial Genomics and Evolution at the London School of Hygiene & Tropical Medicine.

Despite being thought of as an ancient disease, cholera cases are on the rise, with around 1.4 billion people at risk in endemic countries, and an estimated three million to five million cases each year. The disease causes up to 120,000 deaths per year globally.

Dhaka is a megacity in Bangladesh that experiences two seasonal outbreaks of cholera each year. To understand how cholera outbreaks sweep through the population and to highlight the best control strategies, researchers tracked cholera strains at a local level - from people within households who shared a cooking pot and ate together.

Between 2002 and 2005, samples were taken from cholera patients admitted to the Dhaka Hospital of icddr,b in Bangladesh (formerly known as the International Centre for Diarrhoeal Research, Bangladesh). Over a surveillance period of three weeks, follow-up samples were taken from other members in the same household of each cholera patient. In total, 303 Vibrio cholerae samples were collected from 224 individuals across 103 households.

The researchers sequenced the genomes of all the samples to find out how the cholera strains from each person were related and compared them with strains coming from other parts of the globe. They found that nearly 80% of the secondary infections were linked to the first case in that household (within the first five days from that person falling ill).

This meant that once cholera entered the household it was spreading between household members, rather than repeatedly coming in from outside, within this critical time period. This revealed that household control measures are vitally important to stop the spread of cholera.

Professor Nick Thomson said: “Whereas our previous studies have tracked cholera at the global level, here we look at households in a region at high risk of seasonal cholera outbreaks. Our fine-scale genomic data can help identify which control strategies could have the most impact, and we provide genetic tools to measure the effectiveness of household and local interventions in reducing outbreaks.”

Dr Daryl Domman, first author from the Wellcome Sanger Institute, said: “Using genomics, we found that cholera is easily transmitted within the household. Preventing this spread within the household could enormously reduce cholera outbreaks and highlights the need for prioritising local control strategies. This could have a huge impact, not only on the individual households, but also on the entire region.”

Reducing people’s exposure to Vibrio cholera at the household level would help to break the chain of transmission of the disease. Local interventions including better sanitation and hygiene, water chlorination and vaccinating household members could help reduce cholera spread.

Dr Firdausi Qadri, co-lead author from the icddr,b in Bangladesh, said: “Vaccination together with WASH interventions – improved water, sanitation and hygiene – are critical interventions for preventing and controlling the spread of cholera.”


Daryl Domman et al. (2018) Defining endemic cholera at three levels of resolution within Bangladesh. Nature Genetics. DOI: 10.1038/s41588-018-0150-8