Professor Cally Roper

BSc PhD

Professor

in Malaria Genetics

Room

282

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.

020 7927 2616

My research applies evolutionary genetics to address practical problems in malaria control focussing in particular on the threat of antimalarial drug resistance. My current projects include the development of a genetic barcode, mapping resistance mutations in Africa to inform policy on malaria prevention in pregnant women (IPTp), measuring levels of drug selection in the field applied by different treatment policies, and assessing the role of human migration in the dispersal of drug resistant malaria.

Affiliations

Department of Pathogen Molecular Biology

Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Teaching

Module organiser for the distance learning Malaria module.

Research

Barcoding Malaria Parasites: A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains. M.D. Preston, S. Campino, S.A. Assefa, D.F. Echeverry, H. Ocholla, A. Amambua-Ngwa, L. Stewart, D.J. Conway, S. Borrmann, P. Michon, I. Zongo, J-B Ouédraogo, A.A. Djimde, O.K. Doumbo, F. Nosten, A. Pain, T. Bousema, C.J. Drakeley, R.M. Fairhurst, C.J. Sutherland, C. Roper, T.G Clark. Nature Communications (2014) 5:4052.

Mapping the spread of drug resistance mutations in Africa http://www.drugresistancemaps.org/ Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria. R. J. Pearce, H. Pota, M-S B. Evehe, E-H Bâ, G. Mombo-Ngoma, A. L. Malisa, R. Ord, W. Inojosa, A. Matondo, D.A. Diallo, W. Mbacham, I.V.van den Broek, T.D. Swarthout, A. Getachew, S. Dejene, M.P.Grobusch, F. Njie, S. Dunyo, M. Kweku, S. Owusu-Agyei, D. Chandramohan, M. Bonnet, J-P Guthmann, S. Clarke, K.I. Barnes, E. Streat, S.T. Katokele, P. Uusiku, C.O. Agboghoroma, O. Y. Elegba, B. Cissé, I. E. A-Elbasit, H.A. Giha, S.P. Kachur, C. Lynch, J.B. Rwakimari, P. Chanda, M. Hawela, B. Sharp, I. Naidoo, C. Roper. PLoS Medicine (2009) 6(4):e1000055

Measuring drug pressure in a field trial of intermittent preventive treatment of infants (IPTi). A community-randomised evaluation of the effect of IPTi on antimalarial drug resistance in southern Tanzania. R. J. Pearce , R. Ord, H. Kaur, C. Lupala , J. Schellenberg, K. Shirma, F. Manzi, M. Tanner, P. Alonso, H. Mshinda, C. Roper, D. Schellenberg. The Journal of Infectious Diseases (2013) 207, 849-859.

Research Area

Drug resistance

Discipline

Molecular epidemiology

Genetics

GIS/Spatial analysis

Molecular biology

Disease and Health Conditions

Infectious disease

Malaria

Country

Burkina Faso

China

Cameroon

Congo, Dem. Rep.

Congo, Rep.

Colombia

Ethiopia

Gabon

United Kingdom

Ghana

Guinea

Gambia, The

India

Kenya

Sri Lanka

Mozambique

Namibia

Senegal

South Sudan

Tanzania

South Africa

Zambia

Region

Sub-Saharan Africa (all income levels)

World

Selected Publications

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.

Preston, M.D.; Campino, S.; Assefa, S.A.; Echeverry, D.F.; Ocholla, H.; Amambua-Ngwa, A.; Stewart, L.B.; Conway, D.J.; Borrmann, S.; Michon, P.; Zongo, I.; Ouédraogo, J.B.; Djimde, A.A.; Doumbo, O.K.; Nosten, F.; Pain, A.; Bousema, T.; Drakeley, C.J.; Fairhurst, R.M.; Sutherland, C.J.; Roper, C.; Clark, T.G.;

Nat Commun

Molecular surveillance for artemisinin resistance in Africa

Roper, C.; Alifrangis, M.; Ariey, F.; Talisuna, A.; Menard, D.; Mercereau-Puijalon, O.; Ringwald, P.

Lancet Infectious Diseases

Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia

Alifrangis, M.; Nag, S.; Schousboe, M.L.; Ishengoma, D.; Lusingu, J.; Pota, H.; Kavishe, R.A.; Pearce, R.; Ord, R.; Lynch, C.; Dejene, S.; Cox, J.; Rwakimari, J.; Minja, D.T.R.; Lemnge, M.M.; Roper, C.

Emerging Infectious Diseases

Global and local genetic diversity at two microsatellite loci in Plasmodium vivax parasites from Asia, Africa and South America.

Schousboe, M.L. ; Ranjitkar, S. ; Rajakaruna, R.S. ; Amerasinghe, P.H. ; Konradsen, F. ; Morales, F. ; Ord, R. ; Pearce, R. ; Leslie, T. ; Rowland, M. ; Gadalla, N. ; Bygbjerg, I.C. ; Alifrangis, M. ; Roper, C. ;

Malar J

Mapping 'partially resistant', 'fully resistant', and 'super resistant' malaria.

Naidoo, I.; Roper, C.;

Trends Parasitol

Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.

Pearce, R.J.; Pota, H.; Evehe, M.S.; Bâ, e.l.-.H.; Mombo-Ngoma, G.; Malisa, A.L.; Ord, R.; Inojosa, W.; Matondo, A.; Diallo, D.A.; Mbacham, W.; van den Broek, I.V.; Swarthout, T.D.; Getachew, A.; Dejene, S.; Grobusch, M.P.; Njie, F.; Dunyo, S.; Kweku, M.; Owusu-Agyei, S.; Chandramohan, D.; Bonnet, M.; Guthmann, J.P.; Clarke, S.; Barnes, K.I.; Streat, E.; Katokele, S.T.; Uusiku, P.; Agboghoroma, C.O.; Elegba, O.Y.; Cissé, B.; A-Elbasit, I.E.; Giha, H.A.; Kachur, S.P.; Lynch, C.; Rwakimari, J.B.; Chanda, P.; Hawela, M.; Sharp, B.; Naidoo, I.; Roper, C.;

PLoS Med

Intercontinental spread of pyrimethamine-resistant malaria.

Roper, C.; Pearce, R.; Nair, S.; Sharp, B.; Nosten, F.; Anderson, T.;

Science

Antifolate antimalarial resistance in southeast Africa: a population-based analysis

Roper, C.; Pearce, R.; Bredenkamp, B.; Gumede, J.; Drakeley, C.; Mosha, F.; Chandramohan, D.; Sharp, B.

Lancet

See all Professor Cally Roper's Publications

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