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Professor Cally Roper

BSc PhD

Professor
in Malaria Genetics

Room
395

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 2616

My research applies evolutionary genetics to practical problems in malaria control. In particular I am interested in the emergence and spread of antimalarial drug resistance. My research involves mapping resistance mutations in Africa to inform policy on malaria prevention and treatment, and the development of new molecular tools for mapping the dispersal of resistance mutations.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Malaria Centre

Teaching

Module organiser for the distance learning Malaria module.

Research

Barcoding Malaria Parasites: A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.  M.D. Preston, S. Campino, S.A. Assefa, D.F. Echeverry, H. Ocholla, A. Amambua-Ngwa, L. Stewart, D.J. Conway, S. Borrmann, P. Michon, I. Zongo, J-B Ouédraogo, A.A. Djimde, O.K. Doumbo, F. Nosten, A. Pain, T. Bousema, C.J. Drakeley, R.M. Fairhurst, C.J. Sutherland, C. Roper, T.G Clark.   Nature Communications (2014) 5:4052.

Mapping the spread of drug resistance mutations in Africa  http://www.drugresistancemaps.org/   Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria. R. J. Pearce, H. Pota, M-S B. Evehe, E-H Bâ, G. Mombo-Ngoma, A. L. Malisa, R. Ord, W. Inojosa, A. Matondo, D.A. Diallo, W. Mbacham, I.V.van den Broek, T.D. Swarthout, A. Getachew, S. Dejene, M.P.Grobusch, F. Njie, S. Dunyo, M. Kweku, S. Owusu-Agyei, D. Chandramohan, M. Bonnet, J-P Guthmann, S. Clarke, K.I. Barnes, E. Streat, S.T. Katokele, P. Uusiku, C.O. Agboghoroma, O. Y. Elegba, B. Cissé, I. E. A-Elbasit, H.A. Giha, S.P. Kachur, C. Lynch, J.B. Rwakimari, P. Chanda, M. Hawela, B. Sharp, I. Naidoo, C. Roper.   PLoS Medicine (2009) 6(4):e1000055

Measuring drug pressure in a field trial of intermittent preventive treatment of infants (IPTi). A community-randomised evaluation of the effect of IPTi on antimalarial drug resistance in southern Tanzania. R. J. Pearce , R. Ord, H. Kaur, C. Lupala , J. Schellenberg, K. Shirma, F. Manzi, M. Tanner, P. Alonso, H. Mshinda, C. Roper, D. Schellenberg. The Journal of Infectious Diseases (2013) 207, 849-859. 
 

 

Research Area
Drug resistance
Discipline
Molecular epidemiology
Genetics
GIS/Spatial analysis
Molecular biology
Disease and Health Conditions
Infectious disease
Malaria
Country
Burkina Faso
China
Cameroon
Congo, Dem. Rep.
Congo, Rep.
Colombia
Ethiopia
Gabon
United Kingdom
Ghana
Guinea
Gambia, The
India
Kenya
Sri Lanka
Mozambique
Namibia
Senegal
South Sudan
Tanzania
South Africa
Zambia
Region
Sub-Saharan Africa (all income levels)
World

Selected Publications

Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether-lumefantrine and artesunate-amodiaquine in Africa.
Okell LC; Reiter LM; Ebbe LS; Baraka V; Bisanzio D; Watson OJ; Bennett A; Verity R; Gething P; Roper C
2018
BMJ global health
Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V.
Oguike MC; Falade CO; Shu E; Enato IG; Watila I; Baba ES; Bruce J; Webster J; Hamade P; Meek S
2016
International journal for parasitology Drugs and drug resistance
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.
Preston MD; Campino S; Assefa SA; Echeverry DF; Ocholla H; Amambua-Ngwa A; Stewart LB; Conway DJ; Borrmann S; Michon P
2014
Nature communications
Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia
Alifrangis M; Nag S; Schousboe ML; Ishengoma D; Lusingu J; Pota H; Kavishe RA; Pearce R; Ord R; Lynch C
2014
Emerging infectious diseases
Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.
Pearce RJ; Pota H; Evehe MS; Bâ, e.l.- H; Mombo-Ngoma G; Malisa AL; Ord R; Inojosa W; Matondo A; Diallo DA
2009
PLoS medicine
Intercontinental spread of pyrimethamine-resistant malaria.
Roper C; Pearce R; Nair S; Sharp B; Nosten F; Anderson T
2004
Science (New York, NY)
Antifolate antimalarial resistance in southeast Africa: a population-based analysis
Roper C; Pearce R; Bredenkamp B; Gumede J; Drakeley C; Mosha F; Chandramohan D; Sharp B
2003
Lancet
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