Dr Natacha Protopopoff


Assistant Professor
of entomology

Keppel Street
United Kingdom


I am particularly interested in operational research that will help countries to take sound decisions on vector control strategy that is based on scientific evidence. I have spent the last 15 years implementing large scale entomological and parasitological trials evaluating malaria vector control interventions. I joined LSHTM in 2011 and I am currently based in Moshi, (Tanzania) managing randomized control trial investigating the impact of vector control tools on vector outcomes and malaria transmission. I am also involved in the evaluation of a new type of long lasting insecticide nets for the control of resistant malaria vectors.

My background is on biochemistry and undertook a master in environmental sciences and water management. This led me to work with Médecins Sans Frontière as a water and sanitation officer and manage my first malaria vector control project. I spent several years in Burundi managing Indoor Residual Spray campaigns and insecticide treated nets distributions and evaluating the impact of these interventions on vector abundance and malaria prevalence. I completed a PhD in 2008 with the Institute of Tropical Medicine in Antwerp Belgium which investigated the impact of targeted vector control on malaria transmission in the African highlands.

In 2009 I joined the Malaria Consortium as vector control specialist supporting the Uganda, South Sudan, Senegal and Ghana National Malaria Control Programmes to establish their malaria vector control strategy and net distribution systems. I was involved in research to evaluate the durability of LLIN in phase III trials in Uganda. With the vector control division of the Ugandan NMCP I established insecticide resistance susceptibility monitoring in sentinel sites throughout Uganda.


Faculty of Infectious and Tropical Diseases
Department of Disease Control


I teach vector biology and control, give lectures and practical to the East African Diploma of Tropical Medicine & Hygiene held each year in Tanzania. Since 2013, I am a tutor on the malaria module of the Infectious Diseases distance learning programme. I am supervising LSHTM, Kilimanjaro Christian Medical University College (Tanzania) and University of Antwerp (Belgium) MSc dissertation project students in Tanzania.



 1. Community randomized control trials evaluating of new vector control tool and/or strategies.

  • Co Pi and manager of a project funded by MRC/DfID/Wellcome Global Health Trials to evaluate single and combination interventions aimed at controlling malaria transmitted by pyrethroid resistant mosquitoes: a novel long lasting net incorporating a synergist and a long lasting IRS formulation.
  • Manager of a 3 years community randomized control trial evaluating the impact of combining Insecticide Treated Net and Indoor Residual Spraying on Malaria funded by PMI/USAID in Northern Tanzania (2010-2013).
  • Scientific support to a community randomized control trial examining the efficacy of insecticide-treated durable wall liners (ITWL) as a method for malaria control in endemic rural Tanzania funded by PMI/USAID

2. Development of novel malaria vector control tools with IVCC

  • Manager of laboratory (phase I) and small scale studies (phase II) evaluating new long lasting insecticide net or indoor residual spray formulations through the Innovative Vector Control Consortium (IVCC), a Gates funded project

3. Co-PI for a project investigating malaria transmission in Lower Moshi and training medical students in research as part of the Medical Education Partnership Initiative mentored Research and Training (Duke University School of Medicine and KCMC).


Research Area
Clinical trials
Complex interventions
Disease control
Implementation research
Randomised controlled trials
Vector control
Operational research
Vector biology
Disease and Health Conditions
Vector borne disease
South Sudan
Sub-Saharan Africa (all income levels)