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Dr Jennifer Nicholas

BSc MPhil PhD

Associate Professor
of Medical Statistics

Room
G37a

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7958 8119

I joined the LSHTM Department of Medical Statistics at the start of 2012. Before this I was at King's College London Department of Primary Care and Public Health working on a project to evaluate the implementation of NHS health checks in the South London area. I have a PhD in Epidemiology from King's College London and MPhil in Epidemiology from University of Cambridge. Before starting my PhD I worked for two years as a public health epidemiologist in the NHS.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Centres

Statistical Methodology

Teaching

I am lecturer and organiser for the Linear Regression course on MSc Medical Statistics, and module organiser and tutor for Basic Statistics for Clinical Trials on the MSc Clinical Trials (distance learning). I also co-organise and lecture on the Short Course Essentials of Clinical Trials.

Research

My research interests are in randomised clinical trials and in non-randomised clinical studies. I have a methodological interest in the optimisation of clinical trial design in neurology, particularly focusing on trials in dementia and multiple sclerosis.

At the school I have been involved in researching new treatments for people with multiple sclerosis. Currently I am working with the MS Society on design of multi-arm multi-stage clinical trials to assess treatment for progressive multiple sclerosis. I am trial statistician for the MS-STAT2 randomised clinical trial, which is evaluating whether high dose simvastatin can slow progression of disability in secondary progressive multiple sclerosis.

I have also worked with the LSHTM Clinical Trials Unit on trials which examine whether remote ischaemic conditioning can improve clinical outcomes. The REPAIR and ERICCA trials were conducted in patients receiving living donor kidney transplantation and coronary artery bypass surgery respectively. The ongoing ERIC-PPCI trial examines whether remote ischaemic conditioning can improve clinical outcomes following  myocardial infarction.

I have an ongoing collaboration with the Dementia Research Centre, UCL, exploring genetic and other risk factors for the development of dementia and examining how dementia affects cognition, brain imaging and other biomarkers. As part of this work I am a co-investigator on GENFI, an international longitudinal study of familial frontotemporal dementia and working with UCL on the Insight 46 neuroscience sub-study of the MRC National Survey of Health and Development.

Research Area
Clinical trials
Public health
Statistical methods
Electronic health records
Randomised controlled trials
Discipline
Pharmacoepidemiology
Epidemiology
Statistics
Disease and Health Conditions
Neurological disease
Kidney disease
Country
United Kingdom
Region
European Union

Selected Publications

Cognition at age 70: Life course predictors and associations with brain pathologies.
Lu K; Nicholas JM; Collins JD; James S-N; Parker TD; Lane CA; Keshavan A; Keuss SE; Buchanan SM; Murray-Smith H
2019
Neurology
Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.
Lane CA; Barnes J; Nicholas JM; Sudre CH; Cash DM; Malone IB; Parker TD; Keshavan A; Buchanan SM; Keuss SE
2019
JAMA neurology
Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study.
Weston PSJ; Nicholas JM; Henley SMD; Liang Y; Macpherson K; Donnachie E; Schott JM; Rossor MN; Crutch SJ; Butler CR
2018
Lancet neurology
Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.
Weston PSJ; Nicholas JM; Lehmann M; Ryan NS; Liang Y; Macpherson K; Modat M; Rossor MN; Schott JM; Ourselin S
2016
Neurology
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
Rohrer JD; Woollacott IOC; Dick KM; Brotherhood E; Gordon E; Fellows A; Toombs J; Druyeh R; Cardoso MJ; Ourselin S
2016
Neurology
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.
Rohrer JD; Nicholas JM; Cash DM; van Swieten J; Dopper E; Jiskoot L; van Minkelen R; Rombouts SA; Cardoso MJ; Clegg S
2015
Lancet neurology
Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery.
Hausenloy DJ; Candilio L; Evans R; Ariti C; Jenkins DP; Kolvekar S; Knight R; Kunst G; Laing C; Nicholas J
2015
The New England journal of medicine
Altered sense of humor in dementia.
Clark CN; Nicholas JM; Gordon E; Golden HL; Cohen MH; Woodward FJ; Macpherson K; Slattery CF; Mummery CJ; Schott JM
2015
Journal of Alzheimer's disease
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.
Chataway J; Schuerer N; Alsanousi A; Chan D; MacManus D; Hunter K; Anderson V; Bangham CR; Clegg S; Nielsen C
2014
Lancet
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