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Dr Jennifer Nicholas

BSc MPhil PhD

Assistant Professor
of Medical Statistics

Room
G37a

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7958 8119

I joined the LSHTM Department of Medical Statistics at the start of 2012. Before this I completed a PhD in Epidemiology at King's College London on the topic of pharmacoepidemiology and worked in King's College London Department of Primary Care and Public Health on a project evaluating the implementation of NHS health checks in the South London area. I completed an MPhil in Epidemiology at University of Cambridge in 2004/2005 and prior to starting my PhD I worked for two years as an epidemiologist in the NHS.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Centres

Statistical Methodology

Teaching

I am lecturer and organiser for the Regression course on MSc Medical Statistics, and module organiser and tutor for Basic Statistics for Clinical Trials on the MSc Clinical Trials (distance learning). I also co-organise and lecture on the Short Course in Clinical Trials.

Research

My research interests are in randomised clinical trials and in non-randomised clinical studies. I have a methodological interest in the optimisation of clinical trial design in neurology, particularly focusing on trials in dementia and multiple sclerosis.

At the school I have been involved in researching new treatments for people with multiple sclerosis. I am trial statistician for the MS-STAT2 randomised clinical trial, which is evaluating whether high dose simvastatin can slow progression of disability in secondary progressive multiple sclerosis. I was also trial statistician for the phase 2 MS-STAT1 randomised clinical trial, which found that simvastatin slows the rate of whole-brain atrophy and reduces progression of disability in secondary progressive multiple sclerosis.

I have also worked on trials which examine whether remote ischaemic conditioning can improve clinical outcomes. The REPAIR and ERICCA trials were conducted in patients receiving living donor kidney transplantation and coronary artery bypass surgery respectively. The ongoing ERIC-PPCI trial examines whether remote ischaemic conditioning can improve clinical outcomes following  myocardial infarction.

I collaborate with researchers at the Dementia Research Centre, UCL, on several clinical studies that aim to explore how symptomatic and presymptomatic dementia affects cognition, brain imaging and other biomarkers. As part of this work I am a co-investigator on GENFI, an international longitudinal study of familial frontotemporal dementia. I am also collaborating with UCL on the Insight 46 neuroscience sub-study of the MRC National Survey of Health and Development.

Research Area
Clinical trials
Public health
Statistical methods
Electronic health records
Randomised controlled trials
Discipline
Pharmacoepidemiology
Epidemiology
Statistics
Disease and Health Conditions
Cardiovascular disease
Neurological disease
Kidney disease
Country
United Kingdom
Region
European Union

Selected Publications

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.
Weston, P.S. ; Nicholas, J.M. ; Lehmann, M. ; Ryan, N.S. ; Liang, Y. ; Macpherson, K. ; Modat, M. ; Rossor, M.N. ; Schott, J.M. ; Ourselin, S. ; Fox, N.C. ;
Neurology
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.
Ryan, N.S.; Nicholas, J.M.; Weston, P.S.; Liang, Y.; Lashley, T.; Guerreiro, R.; Adamson, G.; Kenny, J.; Beck, J.; Chavez-Gutierrez, L.; de Strooper, B.; Revesz, T.; Holton, J.; Mead, S.; Rossor, M.N.; Fox, N.C.;
Lancet Neurol
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.
Rohrer, J.D.; Nicholas, J.M.; Cash, D.M.; van Swieten, J.; Dopper, E.; Jiskoot, L.; van Minkelen, R.; Rombouts, S.A.; Cardoso, M.J.; Clegg, S.; Espak, M.; Mead, S.; Thomas, D.L.; De Vita, E.; Masellis, M.; Black, S.E.; Freedman, M.; Keren, R.; MacIntosh, B.J.; Rogaeva, E.; Tang-Wai, D.; Tartaglia, M.C.; Laforce, R.; Tagliavini, F.; Tiraboschi, P.; Redaelli, V.; Prioni, S.; Grisoli, M.; Borroni, B.; Padovani, A.; Galimberti, D.; Scarpini, E.; Arighi, A.; Fumagalli, G.; Rowe, J.B.; Coyle-Gilchrist, I.; Graff, C.; Fallström, M.; Jelic, V.; Ståhlbom, A.K.; Andersson, C.; Thonberg, H.; Lilius, L.; Frisoni, G.B.; Pievani, M.; Bocchetta, M.; Benussi, L.; Ghidoni, R.; Finger, E.; Sorbi, S.; Nacmias, B.; Lombardi, G.; Polito, C.; Warren, J.D.; Ourselin, S.; Fox, N.C.; Rossor, M.N.;
Lancet Neurol
Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery.
Hausenloy, D.J. ; Candilio, L. ; Evans, R. ; Ariti, C. ; Jenkins, D.P. ; Kolvekar, S. ; Knight, R. ; Kunst, G. ; Laing, C. ; Nicholas, J. ; Pepper, J. ; Robertson, S. ; Xenou, M. ; Clayton, T. ; Yellon, D.M. ; ERICCA Trial Investigators, . ; COLLABORATORS;Goss, A. ; Desouza, A. ; Relvas, C. ; Morgan, H. ; Saunders, I. ; Donovan, J. ; Booth, J. ; Shah, M. ; Yates, M. ; Chawla, N. ; Stanger, O. ; Savory, R. ; Trimlett, R. ; Gonella, R. ; Wang, S. ; Morgan, T. ; Roesler, V. ; Suri, A. ; Jarvis, C. ; Warren, L. ; Xenou, M. ; Tehrani, S. ; Sivaraman, V. ; Roberts, N. ; Lawrence, D. ; Di Salvo, C. ; Barnard, M. ; Martin, B. ; Smith, A. ; Malik, A. ; Cortez, A. ; O'Donovan, M. ; Shand, N. ; Desai, J. ; Eka, A. ; Williams, A. ; Kunst, G. ; Jessup, J. ; Breeze, J. ; Salaunkey, K. ; Andrews, M. ; Joseph, M. ; Williams, R. ; Bristol, R. ; Patale, S. ; Preston, T. ; Dew, T. ; Hogervorst, V. ; Jenkins, D. ; Kenny, A. ; Freeman, C. ; Kelly, C. ; Salisbury, D. ; King, E. ; Marston, K. ; Fingleton, L. ; Myszko, L. ; Bennett, M. ; Lowry, R. ; Woods, S. ; Fakelman, S. ; Deeley, S. ; Dean, T. ; Howlett, T. ; Hacking, A. ; Pooley, M. ; Sudarshan, C. ; Ng, C. ; Nashef, S. ; Catarino, P. ; Codispoti, M. ; Large, S. ; Dunning, J. ; Nair, S. ; Abuomar, Y. ; Punjabi, P. ; Macys, A. ; Pengelley, C. ; Moscarelli, M. ; Munro, I. ; Scriven, J. ; Smee, J. ; Iddamalgoda, T. ; Chan, K. ; Salam, A.A. ; Jahangiri, M. ; Edwards, B. ; Cousins, E. ; Nyamajiyah, H. ; Clutterbuck, L. ; Smith, M. ; Rajab, M. ; Day, S. ; Blauth, C. ; Damm, J. ; Wilson, K. ; Clack, L. ; Straiton, N. ; Jones, S. ; Clark, S. ; Russell, V. ; Taylor, Y. ; Uppal, R. ; Barrett, C. ; Habada, H. ; Veerapen, J. ; Lungley, J. ; Baig, K. ; Martin, C. ; Andiapen, M. ; Dowlut, S. ; Brookman, P. ; Prossora, M. ; Ritchie, A. ; Birdi, I. ; Pilcher, A. ; Solesbury, A. ; Sevillano, A. ; Hadebe, B. ; Alves, C. ; Alves, D. ; Hamarneh, A. ; Redman, E. ; Butt, G. ; Chitty, H. ; Udeozor, I. ; Hampton-Till, J. ; Byrne, J. ; Guinto, J. ; Tidey, J. ; Hayden, K. ; Goodsell, K. ; Cruse, L. ; Bondoc, M. ; Masuku, M. ; Christmas, N. ; Mguni, N. ; Harding, P. ; Koothoor, R. ; Adeniba, R. ; Theodule, R. ; Tshumi, S. ; Pepper, S. ; Moyo, S. ; McCormick, C. ; Allen, K. ; Trivedi, U. ; MacKenzie, A. ; Cohen, A. ; McGregor, A. ; Hill, A. ; Cowling, C. ; Joyce, E. ; Peasgood, E. ; Roberts, E. ; Wickham, E. ; Duncan, F. ; Duncliffe, J. ; Hyde, J. ; Roberts, L. ; Bennett, L. ; Cooper, L. ; Maccario, M. ; Millar, M. ; Lewis, M. ; Hutchinson, N. ; Skipper, N. ; Cooter, N. ; Kong, R. ; Berg, G. ; Aitken, C. ; Boyd, E. ; Kelly, J. ; Mason, M. ; Small, R. ; Simon, A. ; Hughes, C. ; Gowen, M. ; Dolphin, N. ; Warsama, S. ; Pessotto, R. ; Fairbairn, A. ; Ferrara, A. ; Marshall, L. ; Laird, M. ; Van Dalen, M. ; Morrissey, M. ; De Haan, M. ; Giordano, V. ; Bhabra, M. ; Luckraz, H. ; Smallwood, A. ; Greatbatch, E. ; Jarvis, E. ; Dean-Goodridge, F. ; Phiri, L. ; Kempson, S. ; Metherell, S. ; Angelini, G. ; Treagus, A. ; Gravani, A. ; Hopkins, E. ; Wilcox, J. ; Evans, J. ; Rajakaruna, K. ; Painter, K. ; Wright, K. ; Culliford, L. ; Wahab, M. ; Lambert, P. ; Wyatt, R. ; Underwood, W. ; Keenan, D. ; Paschalis, A. ; Tallon, B. ; Cummings-Fosong, G. ; Phillips, H. ; Iles-Smith, H. ; Palmer, K. ; Maciver, K. ; Doyle, L. ; O'Keeffe, N. ; Evans, S. ; McLoughlin, S. ; Williams, S. ; Kanyama, S. ; Elwood, S. ; Osborne, W. ; Youhana, A. ; Davies, A.S. ; Jones, C. ; Fagan, C. ; Griffiths, J. ; Scott, J. ; Blytt-Jordens, N. ; Thomas, R. ; Morgan, R. ; Mehta, D. ; Waters, A. ; Marco, A.L. ; John, A. ; Luen, A. ; Braim, D. ; Rathod, J. ; Podila, S.R. ; Rajnish, R. ; James, S. ; Roberts, T. ; Unsworth-White, J. ; Stewart, C. ; Brown, C. ; Lloyd, C. ; Waugh, D. ; Alderton, J. ; Tantam, K. ; Barrett, L. ; Pearse, M. ; Persad, N. ; Brockman, P. ; Wosley, R. ; Olver, S. ; Riches, T. ; Colwell, W. ; Briffa, N. ; Alli, A. ; Jenkins, A. ; Weedon, A. ; Bailey, C. ; King, C. ; Okhuoya, F. ; Mackenzie, F. ; Mills, G. ; Lindley, J. ; Humphreys, J. ; Fofie, J. ; Sorrell, J. ; Hill, L. ; Agyemang, M. ; Deighton, M. ; Braidley, P. ; Walker, R. ; Warren, R. ; Kerrison, S. ; Jackson, Y. ; Richens, D. ; Szafranek, A. ; Mahmoud, A. ; Singh, A. ; Skinner, H. ; Skoyles, J. ; Shajar, M. ; Ther, G. ; Muthuswammy, G. ; Richards, J. ; Dakkak, K. ; Wyllie, L. ; Sadhahalli, P. ; Basu, R. ; Jutley, R. ; Bose, A. ; Mitchell, B. ; Brennan, E. ; Hatton, G. ; Angus, K. ; Flannery, L. ; Ullyott, L. ; Helliwell, L. ; Lane, L. ; Puronit, M. ; Caswell, M. ; Pickervance, S. ; Waterhouse, C. ; Vasudevan, V. ; Srivastava, V. ; Yonan, N. ; Moran, A. ; Oommen, A. ; Leonard, D. ; Daniel, D. ; Flook, E. ; Hashmi, F. ; Perks, H. ; Kirwan, M. ; Ferguson, S. ; Mcnamara, T. ; Spyt, T. ; Alexander, D. ; Szostek, J. ; Maxfield, K. ; Hickey, M. ; Williams, M. ; Worthy, S. ; Legi, S. ; Ohri, S. ; Diprose, P. ; Curry, A. ; Wilkinson, K. ; King, A. ; Jarca, A. ; Wadams, B. ; Tyrell, B. ; Bolger, C. ; Grinyer, E. ; Ekins, E. ; Beckett, G. ; Collins, H. ; Crockett, J. ; Piper, J. ; Salmon, K. ; Golder, K. ; Seaward, L. ; Gill, R. ; Deng, W. ; Bannister, W. ; Tantony, N. ; O'Regan, D. ; Wilby, E. ; Birch, S. ; Elliot, S. ; Beardow, Z. ; Goodwin, A. ; Atkinson, B. ; Richardson, C. ; Morley, E. ; Robinson, H. ; Brown, I. ; Thompson, L. ; Finlayson, M. ; Hill, P. ; Simmons, S. ; Cormack, S. ; Abid, Q. ; Sellars, E. ; Delaney, J. ; Machin, J. ; Barnett, L. ; Castro-Foskett, K. ; Griffiths, M. ; Gallagher, S. ; Wain, J. ; Martin, M. ; Bhudia, S. ; Gibson, C. ; Gocher, D. ; Archer, E. ; Ward, G. ; Ting, J. ; Lindsay, J. ; McCauley, M. ; Hawthorne, N. ; Gibbons-Smith, S. ; Clay, S. ;
N Engl J Med
Altered Sense of Humor in Dementia.
Clark, C.N. ; Nicholas, J.M. ; Gordon, E. ; Golden, H.L. ; Cohen, M.H. ; Woodward, F.J. ; Macpherson, K. ; Slattery, C.F. ; Mummery, C.J. ; Schott, J.M. ; Rohrer, J.D. ; Warren, J.D. ;
J Alzheimers Dis
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.
Chataway, J. ; Schuerer, N. ; Alsanousi, A. ; Chan, D. ; Macmanus, D. ; Hunter, K. ; Anderson, V. ; Bangham, C.R. ; Clegg, S. ; Nielsen, C. ; Fox, N.C. ; Wilkie, D. ; Nicholas, J.M. ; Calder, V.L. ; Greenwood, J. ; Frost, C. ; Nicholas, R. ;
Lancet
See all Dr Jennifer Nicholas's Publications