Dr Jennifer Nicholas
BSc MPhil PhD
of Medical Statistics
I joined the LSHTM Department of Medical Statistics at the start of 2012. Before this I completed a PhD in Epidemiology at King's College London on the topic of pharmacoepidemiology and worked in King's College London Department of Primary Care and Public Health on a project evaluating the implementation of NHS health checks in the South London area. I completed an MPhil in Epidemiology at University of Cambridge in 2004/2005 and prior to starting my PhD I worked for two years as an epidemiologist in the NHS.
My research interests are in randomised clinical trials and in non-randomised clinical studies. I have a methodological interest in the optimisation of clinical trial design in neurology, particularly focusing on trials in dementia and multiple sclerosis.
At the school I have been involved in researching new treatments for people with multiple sclerosis. I am trial statistician for the MS-STAT2 randomised clinical trial, which is evaluating whether high dose simvastatin can slow progression of disability in secondary progressive multiple sclerosis. I was also trial statistician for the phase 2 MS-STAT1 randomised clinical trial, which found that simvastatin slows the rate of whole-brain atrophy and reduces progression of disability in secondary progressive multiple sclerosis.
I have also worked on trials which examine whether remote ischaemic conditioning can improve clinical outcomes. The REPAIR and ERICCA trials were conducted in patients receiving living donor kidney transplantation and coronary artery bypass surgery respectively. The ongoing ERIC-PPCI trial examines whether remote ischaemic conditioning can improve clinical outcomes following myocardial infarction.
I collaborate with researchers at the Dementia Research Centre, UCL, on several clinical studies that aim to explore how symptomatic and presymptomatic dementia affects cognition, brain imaging and other biomarkers. As part of this work I am a co-investigator on GENFI, an international longitudinal study of familial frontotemporal dementia. I am also collaborating with UCL on the Insight 46 neuroscience sub-study of the MRC National Survey of Health and Development.