Dr Jennifer Nicholas
Associate Professor
London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
Before I joined LSHTM I worked at King's College London conducting public health research and worked for two years as a public health epidemiologist in the NHS. I have a PhD in Epidemiology from King's College London, in which I investigated methods for analysing routinely collected electronic health care records.
Affiliations
Teaching
I am a member of the course committee for MSc Medical Statistics and for several years was the lecturer and organiser for the linear regression course as part of the Foundations of Medical Statistics module. I have supervised more than ten student summer projects on the MSc Medical Statistics programme and provide support students on the course with NIHR pre-doctoral fellowships.
I am module organiser and tutor for Basic Statistics for Clinical Trials on the MSc Clinical Trials (distance learning). I also co-organise and lecture on the Short Course Essentials of Clinical Trials.
Through my collaboration with the Dementia Research Centre at UCL I have been statistical advisor to several PhD students working on projects in neurology. I have also supervised PhD students working in the area of adaptive trial design.
Research
My research includes both randomised clinical trials and non-randomised clinical studies. I have a methodological interest in clinical trial design in neurology, focusing on trials in dementia and multiple sclerosis. In particular, my research looks at the design of trials that incorporate repeated measures and medical imaging outcomes.
I have been part of the trial statistician team for several multi-centre clinical trials. Currently, my trials work focuses on researching new treatments for people with multiple sclerosis. I am working with the MRC Clinical Trials Unit at UCL on the Octopus multi-arm multi-stage clinical trial to assess treatment for progressive multiple sclerosis, which is funded by the MS Society. I am the trial statistician for the recently completed MS-STAT2 randomised clinical trial, which evaluated whether high dose simvastatin can slow progression of disability in secondary progressive multiple sclerosis. I have also worked with the LSHTM Clinical Trials Unit on trials which examine whether remote ischaemic conditioning can improve clinical outcomes in cardiovascular disease and kidney transplant.
I have an ongoing collaboration with the Dementia Research Centre, UCL, exploring genetic and other risk factors for the development of dementia and examining how dementia affects cognition, brain imaging and other biomarkers. As part of this work I am working with UCL on the Insight 46 neuroscience sub-study of the MRC National Survey of Health and Development.
