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Dr Etheldreda Nakimuli

Associate Professor

London School of Hygiene & Tropical Medicine
Plot 51-59 Nakiwogo Road
Entebbe
Uganda

Etheldreda Mpungu Nakimuli is an Associate Professor of Psychiatry at the London School of Hygiene and Tropical Medicine, based at LSHTM’s MRC Unit in Uganda. She develops and evaluates culturally appropriate mental health interventions for Africans. Her research focuses on the mind-body connection, examining the impact of psychotherapy on physical health and its underlying mechanisms.

Dr. Nakimuli empowers health workers through her virtual SEEK-GSP Academy, fostering mental health capacity building across the African continent. She has won accolades, including the 2016 Elsevier Foundation Award, the 2016 Presidential National Independence Medal of Honor, the 2020 BBC 100 Women, the 2021 Makerere University Outstanding Social Innovation in Health Award, and the 2023 US Mission Outstanding Alum in Health Award. In 2023, she was elected to the Executive Committee of the World Psychiatry Association (WPA) Psychotherapy Section. and later appointed as a Council Member representing Uganda on the World Federation of Psychotherapy Council. With medical and doctoral training from Makerere and Johns Hopkins Universities, and funding from organizations like Grand Challenges Canada and the Wellcome Mental Health Data Prize-Africa, Dr. Nakimuli-Mpungu is committed to advancing mental health research and practice in Africa.

Affiliations

MRC/UVRI and LSHTM Uganda Research Unit

Teaching

 

Dr. Nakimuli is an experienced educator and mentor dedicated to building mental health research and service capacity in Africa. She teaches and supervises students at undergraduate, postgraduate, and doctoral levels, particularly in psychiatry, epidemiology, and global mental health. Her teaching focuses on culturally adapted psychotherapy, the integration of mental health into primary care, and the use of implementation science in low-resource settings.

 

As the founder of the SEEK-GSP Academy, she provides virtual training in Group Support Psychotherapy to a wide range of learners—including community health workers, psychologists, nurses, and social workers—equipping them with skills to deliver mental health support across diverse contexts. She also contributes to curriculum development and capacity strengthening in academic institutions, including Makerere University and the London School of Hygiene and Tropical Medicine, and actively mentors early-career researchers. Through her teaching, Dr. Nakimuli-Mpungu champions the use of locally relevant, evidence-based strategies to address Africa’s mental health treatment gap.

Research

Dr. Nakimuli’s research focuses on advancing mental health equity in Africa through the development, evaluation, and scale-up of culturally adapted, evidence-based psychotherapies. Her work targets vulnerable populations such as people living with HIV, children, adolescents, and caregivers in crisis-affected settings. A core strand of her research explores the mind-body connection, examining how group and tele-support psychotherapy not only alleviates mental distress but also improves physical health outcomes by influencing biological, psychological, and social mechanisms.

 

As a recipient of the Wellcome Mental Health Data Prize: Africa (2024–2026), Dr. Etheldreda Nakimuli-Mpungu is leading a research project aimed at investigating the causal mechanisms through which Group Support Psychotherapy (GSP) alleviates depression among people living with HIV in Uganda. This initiative builds upon her previous work demonstrating the effectiveness of GSP in improving both mental and physical health outcomes. The current project focuses on analyzing existing data to identify the specific components of GSP that contribute most significantly to its success. Insights gained from this research are intended to refine the intervention, enhance training protocols for lay health workers, and inform strategies for scaling up mental health services in low-resource settings.

 

Her work in implementation science assesses the cost-effectiveness and scalability of these interventions, aiming to integrate them sustainably into health systems in alignment with national and global mental health priorities. In addition, she leads longitudinal studies using African birth cohorts to identify early-life predictors of depression and incorporates mechanistic investigations such as neurocognitive and epigenetic analyses. Her preventive focus emphasizes youth mental health, developing early interventions for children and adolescents in humanitarian and post-conflict contexts, while addressing the socioeconomic, developmental, and educational consequences of untreated mental illness. Her transdisciplinary approach bridges psychiatry, public health, epidemiology, digital innovation, and community empowerment to transform the landscape of mental health care in Africa.

Research Area
Global mental health
Psychiatry
Epidemiology
Public health
Disease and Health Conditions
Mood disorders
Anxiety disorders
Mental health
Country
Uganda

Selected Publications

Patient and caregiver lived experiences and mental health service engagement during first-episode psychosis in Uganda: a longitudinal mixed-methods study protocol
Oroma, P; SSEMATA, AS; Ssembajjwe, W; Auma, R; Balinga, S; Aujo, BT; Kaddu, AK; Ampiire, M; Muhwezi, WW; Mwesiga, EK; NAKIMULI, E;
2026
openRxiv
Development and External Validation of a Treatment-Adjusted Machine Learning Model for Precision Allocation of Group-Based Depression Care Among People Living with HIV in Uganda
Babirye, S; Huang, R; Zeng, C; Mutinye, J; Kemigisha, B; Wamala, K; Kasujja, R; Kalani, K; Andres Martinez, R; Nakimuli-Mpungu, E;
2026
Wellcome Open Research
Early and Sustained Mediators of Depression Reduction Six Months Post-Treatment with Group Support Psychotherapy among People Living with HIV in Uganda: A Sequential Mediation Analysis
Nakimuli-Mpungu, E; Zeng, C; Babirye, S; Huang, R; Kemigisha, B; Mutinye Kwesiga, J; Wamala, K; Kasujja, R; Kalani, K; Andres Martinez, R;
2026
Wellcome Open Research
Policy and public health implications for mental health after the COVID-19 pandemic.
Nakimuli-Mpungu, E; Arango, C; Dandona, R; Ford, T; John, A; Jordan, A; Cherop, R; Kola, L; López-Jaramillo, C; Schuster, AM; Knapp, M; Walbaum, M; Opiepie, K; Musoro, F; White, LA; Martsenkovskyi, D; Michael, BD; O'Connor, R; MQ Mental Health Research and The Lancet Psychiatr,; Jones, PB;
2026
The lancet. Psychiatry
Mechanisms and Cost-Effectiveness of Mobile Phone-Based Tele-Support Psychotherapy Delivered by Lay Counselors for Depression Among Youth in Uganda: Secondary Analyses of a Pilot Randomized Controlled Trial
Nakimuli-Mpungu, E; Bwanika, JM; Musinguzi, D; Kwesiga, JM; Wamala, K; Namuli, JD; Akimana, B; Kitaka, SB; Mayora, C; Ochanda, P; Ssengooba, F; Hawkins, C; Cavazos-Rheg, P; Nyirendi, M; Seggane, M; Nachega, JB; Mills, EJ;
2025
Springer Science and Business Media LLC
Prevalence and Factors Associated with Emotional Problems Among HIV-Positive Children and Adolescents with Viral Non-Suppression in Rural Northern Uganda.
Mutinye, JK; Namuli, JD; Akimana, B; Serunjogi, JN; Kitaka, SB; Seggane, M; Kaleebu, P; NYIRENDA, M; Nakimuli-Mpungu, E;
2025
Research Square
Developing and Testing Tele-Support Psychotherapy Using Mobile Phones for Depression Among Youth in Kampala District, Uganda: Study Protocol for a Pilot Randomized Controlled Trial
Nakimuli-Mpungu, E; Mutinye, KJ; Bwanika, JM; Musinguzi, D; CarolineNakanyike,; Iya, J; Kitaka, SB; Akimana, B; Hawkins, C; Cavazos-Rehg, P; Nachega, J; Mills, E; Musisi, S;
2024
PsyArXiv
Labia minora elongation: cultural imperialism or mental health concern?
Mpungu, EN; Aujo, T; Abbo, C; Okello, J; Sekikubo, M; Akol, A;
2023
EClinicalMedicine
The effect of group support psychotherapy on adherence to anti-retroviral therapy and viral suppression among HIV positive young people: Study protocol for a pilot randomized controlled trial.
Nakimuli-Mpungu, E; Wamala, K; Nalugya, JS; Nakanyike, C; Iya, J; Bakeera Kitaka, S; Diana Namuli, J; Akimana, B; Nachega, JB; Mills, EJ; Seggane, M;
2023
Frontiers in health services
Long-Term Effect of Group Support Psychotherapy on Depression and HIV Treatment Outcomes: Secondary Analysis of a Cluster Randomized Trial in Uganda.
Nakimuli-Mpungu, E; Smith, CM; Wamala, K; Okello, J; BIRUNGI, J; Etukoit, M; Mojtabai, R; Nachega, JB; Harari, O; Musisi, S; Mills, EJ;
2022
Psychosomatic medicine
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