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Dr Caroline Minassian

Assistant Professor

United Kingdom

I am an epidemiologist specialising in electronic health records (EHR) research, with a particular interest in maternal health. I hold a BA Hons in Experimental Psychology from Oxford University and an MSc in Epidemiology from LSHTM. My PhD, awarded in 2014, investigated the role of acute infections and inflammation in vascular disease. I have extensive experience working with large-scale, linked healthcare datasets, including UK primary and secondary care records (CPRD and HES) and US administrative claims data (Medicaid and Medicare). My research spans a range of topics, including inflammation and vascular events, pregnancy, and maternal thyroid disease, supported by a UKRI Innovation Fellowship. I am currently Co-Lead of the Electronic Health Records Research Discipline of the NIHR Health Protection Research Unit in Vaccines and Immunisation at LSHTM. In partnership with the UK Health Security Agency, our work leverages electronic health record data to enhance vaccine coverage and inform evidence-based policy in the UK.

 

Affiliations

Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

Teaching

I have been teaching on face-to-face and distance learning MSc modules since 2009, including STEPH, Statistical Methods in Epidemiology, Basic Epidemiology, and the Introductory Course in Epidemiology and Medical Statistics (ICEMS) short course. I have been a Module Organiser for Basic Epidemiology (2009-2013) and for the DL MSc Epidemiology Project module EPM500 (2017-2020). I currently teach on two DL modules: Statistical Methods in Epidemiology (EPM202) and Practical Epidemiology (EPM103).

Research

My main research focus is on maternal health and methods to optimise the identification of pregnancies in electronic health record databases. In 2016, I co-led a collaboration between LSHTM and the Clinical Practice Research Datalink (CPRD) to develop and validate an algorithm to identify and date pregnancies and their outcomes in primary care data. This work established the CPRD Pregnancy Register, a novel research tool that has since supported over thirty published studies. I am particularly interested in optimising the use of the Pregnancy Register alongside emerging data linkages (such as the Maternity Services Dataset, MSDS) to study the uptake and safety of vaccines recommended during pregnancy.

Research Area
Maternal health
Child health
Electronic health records
Research methodology
Immunisation
Pregnancy care management
Epidemiology
Disease and Health Conditions
Cardiovascular diseases

Selected Publications

Identification of misclassified pregnancy episodes in women of childbearing potential exposed to drugs with known teratogenic potential in the CPRD GOLD Pregnancy Register.
Lee, C; Rizzi, S; Bierrenbach, AL; Antunes, L; Nissinen, N-M; Rocha, O; Campbell, J; MINASSIAN, C; Hodgson, S; Broe, A;
2024
Pharmacoepidemiology and drug safety
Identification of misclassified pregnancy episodes in women of childbearing potential exposed to drugs with known teratogenic potential in the CPRD GOLD Pregnancy Register
Lee, C; Rizzi, S; Bierrenbach, AL; Antunes, L; Nissinen, N-M; Rocha, O; Campbell, J; MINASSIAN, C; Hodgson, S; Broe, A;
2023
Wiley
Identification of misclassified pregnancy episodes in women of childbearing potential exposed to drugs with known teratogenic potential in the CPRD GOLD Pregnancy Register
Lee, C; Rizzi, S; Bierrenbach, AL; Antunes, L; Nissinen, N-M; Rocha, O; Campbell, J; MINASSIAN, C; Hodgson, S; Broe, A;
2023
Wiley
Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy.
Cartwright, EJ; Pierret, C; MINASSIAN, C; Esserman, DA; Tate, JP; Goetz, MB; Bhattacharya, D; Fiellin, DA; Justice, AC; Lo Re, V; RENTSCH, CT;
2023
JAMA network open
Preconception Management of Hyperthyroidism and Thyroid Status in Subsequent Pregnancy: A Population-Based Cohort Study.
MINASSIAN, C; Allen, LA; Okosieme, O; Vaidya, B; Taylor, P;
2023
The Journal of clinical endocrinology and metabolism
Supplementary material for: "Preconception management of hyperthyroidism and thyroid status in subsequent pregnancy: a population-based cohort study"
MINASSIAN, C; Allen, LA; Okosieme, O; Vaidya, B; Taylor, P;
2023
London School of Hygiene & Tropical Medicine
Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19 in England: a descriptive cohort study within the OpenSAFELY platform.
OpenSAFELY Collaborative,; TAZARE, J; Walker, AJ; TOMLINSON, LA; Hickman, G; RENTSCH, CT; WILLIAMSON, EJ; BHASKARAN, K; Evans, D; WING, K; Mathur, R; WONG, AY; SCHULTZE, A; Bacon, S; Bates, C; Morton, CE; Curtis, HJ; NIGHTINGALE, E; McDonald, HI; Mehrkar, A; Inglesby, P; Davy, S; MacKenna, B; Cockburn, J; Hulme, WJ; ... GOLDACRE, B.
2022
Wellcome open research
Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19 in England: a descriptive cohort study within the OpenSAFELY platform
The OpenSAFELY Collaborative,; TAZARE, J; Walker, A; TOMLINSON, L; Hickman, G; RENTSCH, C; WILLIAMSON, E; BHASKARAN, K; Evans, D; WING, K; MATHUR, R; WONG, AY S; SCHULTZE, A; Bacon, S; Bates, C; Morton, C; Curtis, H; NIGHTINGALE, E; MCDONALD, H; Mehrkar, A; Inglesby, P; Davy, S; MacKenna, B; Cockburn, J; Hulme, W; ... GOLDACRE, B.
2022
Wellcome Open Res
Risks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform.
WILLIAMSON, EJ; MCDONALD, HI; BHASKARAN, K; Walker, AJ; Bacon, S; Davy, S; SCHULTZE, A; TOMLINSON, L; Bates, C; Ramsay, M; Curtis, HJ; FORBES, H; WING, K; MINASSIAN, C; TAZARE, J; Morton, CE; NIGHTINGALE, E; Mehrkar, A; Evans, D; Inglesby, P; MacKenna, B; Cockburn, J; RENTSCH, CT; MATHUR, R; WONG, AY S; ... KUPER, H.
2021
BMJ (Clinical research ed.)
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