My work spans multiple disciplines (clinical trials, epidemiology, diagnostics, health economics, anthropology) but is unified by an unwavering drive to reduce mortality and morbidity from advanced HIV disease.
I joined the Faculty of Infectious and Tropical Diseases in 2017 and was based in Gaborone, Botswana for four years where I worked as the Lead Clinician for the AMBIsome Therapy Induction OptimisatioN (AMBITION) trial. AMBITION was a phase III randomised controlled trial of a single, high-dose liposomal amphotericin regimen for HIV-associated cryptococcal meningitis and recruited patients from six sites across five countries in Southern Africa.
I returned to the UK in 2021 and following the success of the trial I am co-investigator on a number of research and non-research grants aimed at maximising the impact of the AMBITION regimen in routine care settings and applying research advances in cryptococcal meningitis to other HIV-associated fungal infections.
Alongside research I work two-days a week at King's College Hospital NHS Foundation Trust as a HIV and Sexual Health doctor. My work within the NHS is strongly focused on supporting individuals living with HIV who have complex medical and social needs to engage in lifelong care.
Affiliations
Teaching
I am module organiser of HIV 3174 which is an intensive face-to-face module taking place in Term 3. I lead the HIV component of the Diploma in Tropical Medicine and Hygiene and am a distance learning tutor on the IDM 501 HIV/AIDS module. I supervise research projects conducted by MSc students and I am currently supervising four PhD students. I have completed Module 1 and Module 2 of the Postgraduate Certificate in Learning and Teaching and am a Fellow of the Higher Education Academy.
Research
I am involved in a number of ongoing research projects including:
IMPRINT - an NIHR Global Health Research Group for HIV-associated fungal infections
SHARE-CM - an implementation project aimed at reducing mortality from cryptococcal meningitis in routine care
EFFECT - a phase III clinical trial of combination anti-fungal therapy for cryptococcal antigenaemia
5FC PROTECT - a phase II clinical trial of a sustained-release formulation of flucytosine for cryptococcal antigenaemia
IMPALA - a phase III clinical trial of long-acting injectable antiretroviral therapy for individuals with a history of challenges with adherence to oral treatment
NIRVANA - a phase II clinical trial of oral valganciclovir for people hospitalised with advanced HIV disease and cytomegalovirus viraemia
LATCH - an implementation project supporting people living with HIV in the UK who have complex medical and social needs to receive long-acting injectable antiretroviral therapy
Selected Publications
