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Ya Jankey JAGNE

Senior Research Associate

MRC Unit the Gambia
Banjul
United Kingdom

I am a post doctoral Immunologist working within the Vaccines and Immunity Theme. My research focuses on understanding the immune response to infectious diseases and vaccination particularly in early childhood. I have gained extensive experience in various immunological and molecular techniques over the years and have applied these skills in a diverse range of studies on infectious diseases such as malaria, influenza, SARS CoV-2, and Streptococcus pyogenes (GAS). I currently co-lead the Group A strep Immunology work in The Gambia. 

 

I also support the Immunology research laboratories platform at MRC Unit, The Gambia which host permanent research groups for Infant Immunology, TB Immunology and Malaria with more than 60 technical and research staff using the facilities. 

Affiliations

MRC Unit The Gambia at LSHTM

Teaching

I co-organized and lectured on the in-house Basic Immuunology course at the MRC Unit, The Gambia. I also supervise the laboratory work of BSc and MSc students that are on secondment at MRC Gambia Unit for their research work. I am a tutor on the Infectious Diseases by Distance Learning module at LSHTM.

Research

My current research focuses on understanding immune response to naturally occuring Streptococcus pyogenes skin and pharyngeal infections in Gambian children and exploring protective immune responses to Group A Strep human challenge in healthy Gambian adults using the GAS human challenge model. Understanding the immune responses to GAS in African populations is crucial for identifying correlates of protection and GAS vaccine development, given the limited immunological data available in this region.

Selected Publications

Impact of SARS-CoV-2 exposure history on antibody kinetics and correlates of protection in The Gambia
Hodgson, D; Wenlock, RD; Barratt, N; Gomes, M; JAGNE, YJ; JOBE, D; JARJU, S; Danso, M; Temperton, N; KAMPMANN, B; FLASCHE, S; KUCHARSKI, A; De Silva, TI;
2026
openRxiv
Publisher Correction: Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting.
KEELEY, AJ; Camara, FE; Armitage, EP; De Crombrugghe, G; Sillah, J; Fofana, ML; Rollinson, V; Senghore, E; Jammeh, M; Whitcombe, AL; Bittaye, A; Ceesay, H; Ceesay, I; Samateh, B; Manneh, M; Carducci, M; Rovetini, L; Boero, E; Massai, L; Sanyang, LC; Camara, O; Cessay, EE; Iturriza, M; Moriel, DG; KUCHARSKI, A; ... De Silva, TI.
2025
Nature medicine
Integrative mapping of preexisting influenza immune landscapes predicts vaccine response.
Hao, S; Tomic, I; Lindsey, BB; JAGNE, YJ; Hoschler, K; Meijer, A; Carreño Quiroz, JM; Meade, P; Sano, K; Peno, C; Costa-Martins, AG; Bogaert, D; KAMPMANN, B; Nakaya, H; Krammer, F; De Silva, TI; Tomic, A;
2025
The Journal of clinical investigation
Induction of hemagglutinin stalk reactive antibodies by the administration of a live-attenuated influenza virus vaccine in children.
Carreño, JM; Meade, P; Sogodogo, NF; Sano, K; Tcheou, J; Raskin, A; Singh, G; Fried, M; Loganathan, M; Francis, B; Bielak, D; JAGNE, YJ; Salah, HJ; Krammer, F; DE SILVA, TI;
2025
iScience
Compartmentalised mucosal and blood immunity to SARS-CoV-2 is associated with high seroprevalence before the Delta wave in Africa.
JAGNE, YJ; JOBE, D; Darboe, A; Danso, M; Barratt, N; Gomez, M; Wenlock, R; Jarju, S; Sylva, EL; Touray, AF; Toure, F; Kumado, M; Saso, A; Zafred, D; Nicklin, M; Sayers, J; Hornsby, H; Lindsey, B; SESAY, AK; Temperton, N; KUCHARSKI, A; Hodgson, D; DE SILVA, T; KAMPMANN, B;
2025
Communications Medicine
Interactions between live attenuated influenza vaccine and nasopharyngeal microbiota among children aged 24-59 months in The Gambia: a phase 4, open-label, randomised controlled trial.
Peno, C; JAGNE, YJ; Clerc, M; Balcazar Lopez, C; ARMITAGE, EP; Sallah, H; Drammeh, S; Senghore, E; Goderski, G; Van Tol, S; Meijer, A; Ruiz-Rodriguez, A; De Steenhuijsen Piters, WA A; De Koff, E; JARJU, S; Lindsey, BB; Camara, J; Bah, S; MOHAMMED, NI; KAMPMANN, B; CLARKE, E; Dockrell, DH; DE SILVA, TI; Bogaert, D;
2025
The Lancet. Microbe
Microfluidic qPCR for detection of 21 common respiratory viruses in children with influenza-like illness.
Saville, TJ; Colton, H; Jarju, S; ARMITAGE, EP; Drammeh, S; Tazzyman, S; JAGNE, YJ; Sallah, HJ; Senghore, E; Evans, CM; Darton, TC; DE SILVA, TI;
2024
Scientific reports
High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia.
Jarju, S; Wenlock, RD; Danso, M; JOBE, D; JAGNE, YJ; Darboe, A; Kumado, M; Jallow, Y; Touray, M; Ceesay, EA; Gaye, H; Gaye, B; Tunkara, A; Kandeh, S; Gomes, M; Sylva, EL; Toure, F; Hornsby, H; Lindsey, BB; Nicklin, MJ; Sayers, JR; SESAY, AK; KUCHARSKI, A; HODGSON, D; KAMPMANN, B; ... DE SILVA, TI.
2024
Nature communications
Streptococcus pyogenes Colonization in Children Aged 24-59 Months in the Gambia: Impact of Live Attenuated Influenza Vaccine and Associated Serological Responses.
KEELEY, AJ; Groves, D; ARMITAGE, EP; Senghore, E; JAGNE, YJ; Sallah, HJ; Drammeh, S; Angyal, A; Hornsby, H; De Crombrugghe, G; Smeesters, PR; Rossi, O; Carducci, M; Peno, C; Bogaert, D; KAMPMANN, B; MARKS, M; Shaw, HA; Turner, CR; DE SILVA, TI;
2023
The Journal of infectious diseases
SARS-CoV-2 Incidence and Re-Infection During Delta and Omicron Ba.1 Waves in the Gambia: Results from a Prospective Household Cohort Study in a Population with Low SARS-CoV-2 Vaccine Coverage
Jarju, S; Wenlock, R; Danso, M; Jobe, D; JAGNE, YJ; Darboe, A; Kumado, M; Jallow, Y; Touray, M; Ceesay, E; Gaye, H; Gaye, B; Tunkara, A; Kandeh, S; Gomes, M; Sylva, E-L; Toure, F; Hornsby, H; Lindsey, BB; Nicklin, MJ H; Sayers, JR; Sesay, AK; Kucharski, AJ; Hodgson, D; Kampmann, B; ... De Silva, TI.
2023
Elsevier BV
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