Dr Ozan Gundogdu
BSc MSc PhD
Principal Scientific Officer
Ozan Gundogdu joined the LSHTM in 2004 and is a dual qualified bioinformatician and microbiologist. Before joining the School he completed a BSc Honours in Molecular Biology followed by an MSc Computer Science (Commendation), both at the University of Hertfordshire. His undergraduate also contained an industrial placement year which was completed at RAFT - Institute of Plastic Surgery, where he was research assistant in the Molecular Biology group. Ozan completed his PhD in 2011 studying the microbial pathogenesis of Campylobacter jejuni and then completed a two year Bill & Melinda Gates foundation funded postdoctoral position investigating pit latrine characteristics using metagenomics based applications within the Department of Disease Control, LSHTM. Ozan has since continued to study Campylobacter and related enteric pathogens using classical molecular microbiology techniques along with cutting-edge omics based approaches e.g. genomics, transcriptomics and metagenomics.
- 28 peer reviewed manuscripts; h-index of 12.
- >£250,000 research funding awarded from three grants.
- Currently co-supervising 3 PhD students.
- >30 staff/student supervision/advisory/support since 2011.
- Reviewed >15 manuscripts for multiple journals since 2013, and >5 grant applications for multiple funding bodies totalling £20 million since 2013.
Ozan has successfully completed the Postgraduate Certificate in Learning and Teaching (Full Certificate) at the LSHTM and has become a Fellow of the Higher Education Academy (FHEA). He has a wide range of teaching activities which include:-
- Lecturing on the "Molecular Biology Research Progress & Applications" (3160) module (since 2009)
- Lecturing on the "Molecular Biology" (3333) module (since 2011)
- Both above lectures are part of the Molecular Biology of Infectious Diseases (MBID) and Medical Microbiology (MM) MSc courses at the LSHTM
- Laboratory and faculty demonstrations as part of MBID and MM courses (since 2006)
- MSc exam marking and invigilation (since 2006)
- Tutoring MSc students throughout the academic year (12 students since 2006)
- Advisory panel for PhD students (two students since 2011)
- PhD upgrade (two students 2014, 2016) and viva (one student 2017) examiner
- Teaching internal and external researchers about a number of faculty equipment and also data analysis techniques (since 2004)
- Setting up modules as part of a distance learning course (IDM602)
- Member of Senate Council
- Bioinformatics Trainer for MRC Gambia Genomics Training Camp (2018)
Ozan currently co-supervises three PhD students and also co-supervises MSc research projects at the LSHTM (nine students since 2006).
Along with teaching, Ozan is the Head of Sequencing at the LSHTM which includes an Illumina MiSeq and an ABI3730 sequencer. He is actively involved in enhancing the School's sequencing / bioinformatics set-up and is responsible for running and maintaining the Genome Resource Facility within the Pathogen Molecular Biology department and has created and runs the Genome Resource Facility (GRF) website.
Ozan's research interests and vision are to study the physiology and pathogenesis of Campylobacter (the leading human foodborne pathogen), and other related enteric microorganisms, and importantly to link our basic microbiological knowledge to translational research in real life settings. Ozan believes only when we connect these two elements will we be able to implement intervention and control strategies within the food chain. Over the past 15 years, he has utilized classical molecular microbiology techniques, and linked his bioinformatics skills to provide cutting-edge omics based approaches such as genomics, transcriptomics and metagenomics in his research (28 peer reviewed manuscripts; h-index of 12).
Current research themes for studying Campylobacter and other enteric microorganisms include:-
- Mechanisms of response to environmental and host stress
- Prevalence and characterising the Type Six Secretion Systems (T6SS)
- Survival and persistence mechanisms in relation to host cells
- Investigating the genomic and phenotypic properties of foodborne outbreaks e.g. Listeria monocytogenes
- Explore the chicken microbiome and investigate Campylobacter survival and persistence to infer control strategies within the food chain.
Current PhD students (3):-
- Janie Liaw (LSHTM) - 2016 - Present. Co-supervisors Dr Ozan Gundogdu and Professor Nick Dorrell. Project - Investigation of the role of the Campylobacter jejuni Type VI Secretion System in bacterial secretion of virulence factors and interaction with host cells.
- Geunhye Hong (LSHTM) - 2018 - Present. Co-supervisors Dr Ozan Gundogdu and Professor Nick Dorrell. Project - Investigating Campylobacter jejuni interactions with endoplasmic reticulum in intestinal epithelial cells resulting in induction of the unfolded protein response.
- Elizabeth Attree (RVC) - 2018 - Present. Co-supervisors Dr Ozan Gundogdu, Professor Damer Blake, Professor Fiona Tomley and Dr Dong Xia. Project - A multi-omics approach to improve Eimeria functional genome annotation.
Current and past advisory panel for PhD students (2):-
- Daiani Teixeira (LSHTM) - 2011-16. Project - The role of the MarR transcriptional regulators RrpA and RrpB in the response of Campylobacter jejuni to oxidative and aerobic stress.
- Mateusz Hasso Agopsowicz (LSHTM) - 2014-18. Project - A Study Of Factors Underlying BCG Immunogenicity Differences Across Countries: The Influence Of DNA Methylation Patterns And Antigen Presenting Cells.
Current and past MSc research project students co-supervised with Professor Nick Dorrell at the LSHTM (9):-
- Maria Peila - 2004-05. Project - Comparative phylogenomics of the foodborne human pathogen Campylobacter jejuni.
- Fatma Dalgakiran - 2009-10. Project - Pathogenesis of outer membrane vesicles (OMVs) by using Campylobacter jejuni mutant.
- Sarah Leir - 2010-11. Project - Characterising the Campylobacter oxidative stress response.
- Banaz Mohammad - 2011-12. Project - Investigation of Campylobacter jejuni oxidative and aerobic stress responses.
- Naomi Henderson - 2012-13. Project - Investigating the oxidative stress response in Campylobacter jejuni.
- Maria Garza Valles (RVC visiting student) - 2013-14. Project - Ecology of Campylobacteriosis in a Tanzanian rural village (Supervisor Professor Richard Kock); as part of the Strengthening food and nutrition security through family poultry and crop integration in Tanzania and Zambia (Principle Investigator Professor Robyn Alders).
- Cadi Davies - 2014-15. Project - Investigation of the role of the Campylobacter jejuni Type VI secretion system in bacterial secretion of virulence factors and interactions with host cells.
- Chloe Wragg-Kerridge - 2015-16. Project - Investigation of the role of Campylobacter jejuni Type VI secretion system in bacterial secretion of virulence factors and interactions with host cells.
- Geunhye Hong - 2016-17. Project - Investigation of the role of the Campylobacter jejuni Type VI secretion system (T6SS) and the oxidative stress response.
Current and past supervision and hosting of visitors with laboratory/bioinformatics based projects (5):-
- Maria Ugarte-Ruiz (Universidad Complutense Madrid, Madrid, Spain) - June 2014 - March 2015. On her PhD thesis (2012-16) titled - Detection and characterization of Campylobacter from animals, food and sewage.
- Gianna Di Sario (University of Urbino, Urbino, Italy) - October 2016 - March 2017. On her PhD thesis (2014-17) titled - Investigation of the effects of Campylobacter jejuni virulence factors in human cells: different pathways involved.
- Aaron McKenna (Moy Park, Belfast, U.K) - October 2017 and February 2019. On his PhD thesis (2015 - Present) titled - Efficient prevention of Campylobacter spp. entrance in broiler houses improves flock performance at slaughter.
- Dr Alexandros Stratakos (Agri-Food and Biosciences Institute, Belfast, U.K) - March 2018. Project - Whole genome sequencing and bioinformatics analysis of Salmonella, Listeria and Escherichia species.
- Cadi Davies (LSHTM) - 2017 - Present. Project - Campylobacter jejuni mechanisms of outer membrane vesicles (OMV) production.
A number of national and international collaborations have been established to allow future research and funding opportunities:-
- Professor Nicolae Corcionivoschi and Dr Alexandros Stratakos at Agri-Food and Biosciences Institute, Belfast, U.K
- Dr Ursula Lavery and Dr Anne Richmond at Moy Park, Belfast, U.K
- Dr Dong Xia, Dr Androniki Psifidi, Professor Damer Blake and Professor Fiona Tomley at Royal Veterinary College, London, U.K
- Dr Alan Walker at University of Aberdeen, Aberdeen, U.K
- Dr Maria Ugarte-Ruiz and Professor Lucas Domínguez Rodríguez at Universidad Complutense Madrid, Madrid, Spain
- Dr Umer Zeeshan Ijaz and Dr Paul Everest at University of Glasgow, Glasgow, U.K
- Dr Arnoud van Vliet at University of Surrey, Guildford, U.K
- Dr Barbara Canonico at University of Urbino, Urbino, Italy
- Dr Mona Bajaj-Elliott at UCL GOS Institute of Child Health, London, U.K
- Dr Gianna Di Sario at UCL School of Pharmacy, London, U.K
- Professor Martin Antonio at MRC Gambia LSHTM
- Dr Anuradha Ravi, Dr Andrew Page and Professor Mark Pallen at Quadram Institute, Norwich, U.K
- £187,000 from Safefood in collaboration with Professor Nicolae Corcionivoschi to study risk profiling of Listeria in ready-to-eat foods (RTE) and determination of control strategies and practical interventions (2016).
- £10,000 from Agri-Food and Biosciences Institute in collaboration with Professor Nicolae Corcionivoschi to study the effects of the natural antimicrobial peptide carvacrol on the delayed onset of Campylobacter (2016).
- £50,000 from Moy Park, Belfast, U.K as Co-Investigator to study the gut microbiome of chickens over the course of 35 days and to investigate the onset of Campylobacter (2017).
In relation to Campylobacter, he has completed the full re-annotation of the C. jejuni NCTC11168 genome (in collaboration with the Sanger Institute) and has created and runs the Campylobacter Resource Facility (CRF) website. He has also linked to a number of additional internal and external projects which include a next-generation sequencing/bioinformatics theme with the aim of enhancing research output and funding opportunities.
Ozan is active in presenting at national and international conferences relating to Campylobacter research and has presented at a number of meetings (12 since 2007), most recently an oral presentation at the CHRO 2017, Nantes, France. He is a full member of the Microbiology Society (Previously known as the Society of General Microbiology) and an Associate Faculty Member of Faculty of 1000 (post-publication peer review). Recently he has been selected as a Scientific Committee member for CHRO 2019 (Belfast). He is also active in refereeing manuscripts from different journals (>15 manuscripts since 2013) and grant applications from different funding bodies (>5 totalling £20 million since 2012).
Languages - English, Turkish and Spanish