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Prof Stephen Evans

Emeritus Professor of Pharmacoepidemiology

United Kingdom

My first degree was in physics and chemistry and included a year in the US doing physics and philosophy. Having worked in computing I did the MSc in Medical Statistics at LSHTM and worked in statistics and computing at The London Hospital and Medical College for 25 years, leaving there in 1995 as Prof of Medical Statistics, and was made Hon. Prof at LSHTM. I was then at the UK Medicines Control Agency (now MHRA) and briefly at Quintiles where I mainly worked on the Bristol Royal Infirmary Inquiry. I joined LSHTM part-time on retirement in 2002. I have been (until June 2018) a European Commission appointed independent Expert member of the Pharmacovigilance (Drug Safety) and Risk Assessment Committee at the European Medicines Agency. I was President of the International Society of Pharmacoepidemiology for 2010/2011. From October 2022 I am Emeritus and do not act as a supervisor of PhD students.

I continue to be involved in CEPI activities and in the OpenSafely collaboration.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Centres

Centre for Data and Statistical Science for Health
Antimicrobial Resistance Centre

Teaching

I helped start the LSHTM short course in pharmacoepidemiology and pharmacovigilance and teach on that course and the Practical Pharmacoepidemiology short course. I have also contributed to the DL MSc in Clinical Trials and the MSc in Medical Statistics.

Research

Effects of medicines, both drugs and vaccines, is my major interest. Assessment of effiacy, safety and risk in trials and epidemiological studies, especially in electronic health records, are the main topics.
I have suggested methods for use in analysis of spontaneous reports of suspected adverse reactions to drugs and vaccines, and continue to contribute to this field, known as pharmacovigilance.

I am also interested in detection of scientific fraud and misconduct, especially in clinical trials.

I have extensive experience in data monitoring committees for both drug and vaccine trials.
Research Area
Medical and vital statistics
Pharmacoepidemiology
Epidemiology
Disease and Health Conditions
Diabetes
Heart disease
Cancer
Infectious diseases
Country
Singapore

Selected Publications

OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients
WILLIAMSON, E; Walker, AJ; BHASKARAN, K; Bacon, S; Bates, C; Morton, CE; Curtis, HJ; Mehrkar, A; Evans, D; Inglesby, P; Cockburn, J; MCDONALD, HI; MacKenna, B; TOMLINSON, L; DOUGLAS, IJ; RENTSCH, CT; MATHUR, R; WONG, A; GRIEVE, R; Harrison, D; Forbes, H; SCHULTZE, A; Croker, R; Parry, J; Hester, F; ... GOLDACRE, B.
2020
MedRxiv
Application and optimisation of the Comparison on Extreme Laboratory Tests (CERT) algorithm for detection of adverse drug reactions: Transferability across national boundaries.
Tham, MY; Ye, Q; Ang, PS; Fan, LY; Yoon, D; Park, RW; Ling, ZJ; Yip, JW; Tai, BC; EVANS, SJ; Sung, C;
2017
Pharmacoepidemiology and drug safety
The importance of investing in data, models, experiments, team science, and public trust to help policymakers prepare for the next pandemic.
GRIEVE, R; Yang, Y; ABBOTT, S; Babu, GR; Bhattacharyya, M; Dean, N; EVANS, S; Jewell, N; Langan, SM; Lee, W; Molenberghs, G; SMEETH, L; Williamson, E; Mukherjee, B;
2023
PLOS global public health
Comparative effectiveness of nirmatrelvir/ritonavir versus sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised high-risk patients during Omicron waves: observational cohort study using the OpenSAFELY platform.
ZHENG, B; Tazare, J; Nab, L; Green, AC; Curtis, HJ; MAHALINGASIVAM, V; HERRETT, EL; COSTELLO, RE; EGGO, RM; Speed, V; Bacon, SC; Bates, C; Parry, J; Cockburn, J; Hester, F; Harper, S; Schaffer, AL; Hulme, WJ; Mehrkar, A; EVANS, SJ; MacKenna, B; GOLDACRE, B; DOUGLAS, IJ; TOMLINSON, LA; OpenSAFELY Collaborative,;
2023
The Lancet Regional Health - Europe
hdps: A suite of commands for applying high-dimensional propensity-score approaches
TAZARE, J; SMEETH, L; EVANS, SJ W; DOUGLAS, IJ; WILLIAMSON, EJ;
2023
The Stata Journal: Promoting communications on statistics and Stata
Association Between Fluoroquinolone Use and Hospitalization With Aortic Aneurysm or Aortic Dissection.
Brown, JP; WING, K; LEYRAT, C; EVANS, SJ; MANSFIELD, KE; WONG, AY S; SMEETH, L; Galwey, NW; DOUGLAS, IJ;
2023
JAMA cardiology
Association between living with children, vaccination, and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England during 2021–22
COWLING, TE; Forbes, H; Wing, K; TAZARE, J; SCHULTZE, A; Morton, CE; Bacon, S; MacKenna, B; Walker, AJ; Hulme, W; Bates, C; Mehrkar, A; Curtis, HJ; Evans, D; Inglesby, P; Davy, S; Cockburn, J; Parry, J; Hester, F; Harper, S; Douglas, IJ; EVANS, SJ W; BHASKARAN, K; WILLIAMSON, EJ; EGGO, RM; ... TOMLINSON, LA.
2023
Wellcome Open Research
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