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Anti-fibrinolytics Trialists Collaboration

The Anti-fibrinolytics Trialists Collaboration (ATC) is an international collaboration to conduct individual patient data meta-analyses of results from randomised trials of anti-fibrinolytics versus placebo.

The lead investigators of all completed and ongoing trials of anti-fibrinolytics that involve 1000 or more patients are invited to join the collaboration and contribute individual patient data.

The ATC has been set up to address important clinical questions regarding the effects of anti-fibrinolytics that cannot be answered by individual trials or by standard meta-analyses based on aggregate data.

The ATC is co-ordinated from the London School of Hygiene & Tropical Medicine Clinical Trials Unit.

Participating Trials
Participating Trials Anti-fibrinolytics Trialists Collaboration

As of January 2018, the following trials of anti-fibrinolytics involving 1000 or more patients have agreed to join the collaboration and contribute individual patient data.

Tranexamic acid versus placebo  







Scientific Papers
Publications List
Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40,138 bleeding patients
Angèle Gayet-Ageron, David Prieto-Merino, Katharine Ker, Haleema Shakur, François-Xavier Ageron, Ian Roberts, for the Antifibrinolytic Trials Collaboration
2017 S0140-6736(17)32455-8
Contact us
Contact us Anti-fibrinolytics Trialists Collaboration

Katharine Ker, ATC co-ordinator
Clinical Trials Unit
London School of Hygiene & Tropical Medicine
Keppel Street
London WC1E 7HT, UK