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Mosquito innate immunity and malaria transmission blocking

The mosquito innate immune system forms a robust barrier to infection by the malaria parasite. After entering the mosquito via a blood meal, malaria parasites are sequentially attacked by an array of immune responses, each of which has a huge impact on the parasite population size. Targeted and high throughput genetic screens identified several mosquito and parasite genes that are critical for resistance to infection and immune evasion/tolerance, respectively. These discoveries opened the path for the design and development of interventions aiming to block malaria transmission. They include among others the engineering of genetic traits aiding mosquitoes to halt the development and transmission of malaria parasites and the spread of these genetic traits in wild mosquito populations via gene drives


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