Molecular consequences of genomic variation associated with drug resistance in TB and Malaria
Dr Nick Furnham will deliver this talk entitled 'Molecular consequences of genomic variation associated with drug reistance in TB and Malaria'.
Genomic studies of Mycobacterium tuberculosis bacteria have revealed loci associated with resistance to anti-tuberculosis drugs. However, the molecular consequences of polymorphism within these candidate loci remain poorly understood. The talk will summarise the development and findings of a new computational protocol to quantify the effects of point mutations conferring resistance to three major anti-tuberculosis drugs. In addition, the use of this protocol will be discussed in understanding the molecular effects of in vivo polymorphisms co-located with in vitro induced mutations conferring resistance to inhibitors proposed for the treatment of malaria.