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DUSP4 regulates STING- and RIG-I-mediated signalling in response to microbial infection

Detection of cytosolic nucleic acids by pattern recognition receptors including STING and RIG-I leads to activation of multiple signalling pathways that culminate in the production of type I interferons (IFNs) which are vital for host survival during virus infection. In addition to immune modulatory functions, type I IFNs are also associated with autoimmune diseases. Hence, it is important to elucidate the mechanisms that govern their expression. We identified the critical regulatory function of a molecule known as DUSP4 in innate immune signalling. Mice deficient in DUSP4 are more resistant to both RNA and DNA virus infection, but are more susceptible to malaria, compared to control. In this talk, the mechanism underlying the regulation of IRF3-type I IFN system by DUSP4 will be presented and discussed.



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