The Challenges of Estimating the Burden of AMR
Antimicrobial resistance is widely recognised to be a major threat to global health, but the current burden of disease is difficult to quantify. Estimation of mortality from AMR is needed at national and global levels to inform healthcare providers and policy makers, who need an evidence base for prioritisation of interventions.
Underlying challenges to estimating the burden of AMR include lack of linked clinical and microbiological data, sparsity of data in low and middle income countries (LMIC), data quality issues, selection bias of available data, and the difficulties of establishing causality. This talk will discuss the key challenges, including a summary of the underlying assumptions, limitations and comparability of methods used for estimation. Audience participation will be welcomed for this discussion.
Susanna Dunachie, Department of Tropical Medicine, Oxford University
I trained as a doctor in Microbiology and Infectious Diseases in Oxford, Glasgow and Newcastle, and in did a PhD with Adrian Hill and Helen Fletcher in Oxford on vaccine clinical trials and immunology. Since 2011 I have conducted research in Thailand on the host response to bacterial pathogens including Burkholderia pseudomallei(melioidosis), Orientia tsutsugamushi (scrub typhus) and Mycobacterium tuberculosis (TB), based at the Mahidol-Oxford Tropical Medicine Research Unit in Bangkok. Through my time in Thailand liaising with microbiologists in the Southeast Asia region I developed an interest in the challenges of addressing antimicrobial resistance. I am now the clinical microbiologist for the Global Burden of Disease Antimicrobial Resistance project (GBD-AMR) which is an Oxford based collaboration with the Institute for Health Metrics and Evaluation (IHME) at University of Washington in Seattle. This project seeks to collect and share data on the burden of morbidity and mortality caused by AMR, and develop maps of the likely burden of AMR.