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Dr Matthew Yeo

BSc MSc PhD

Assistant Professor
Programme Director for MSc Control of Infectious Diseases (CID)

Room
331

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
02079272814

 

Matthew returned to academia after a first career in the phamaceutical sector, and completed his PhD at the LSHTM on the genetic diversity of Trypanosoma cruzi the causative agent of Chagas disease in 2003. Current research involves the development of transgenic technologies, for example CRISPR-Cas9 gene drive, applied to insect vectors and associated parasites funded by the Wellcome Trust. Also the mechanisms of genetic exchange, phyloepidemiology, diagnostics and control of vectors of both Leishmania and Trypanosoma cruzi.

 

 

 

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Teaching

Matthew is Programme Director for the Control of Infectious Disease Course. Previous Chair of the Board of Examiners (MSc Control of Infectious Diseases) and a member of the CID course committee, deputy module organiser for CID and MBID course modules. He acts as a course tutor, and undertakes and organises numerous lectures and practicals for various MSc courses and associated modules. Subjects span vector biology, diagnostics, molecular biology, parasitology, phyloepedemiology and phylogenetics. Matthew supervises PhD students and numerous visiting research fellows, interns and MSc students during their summer projects. Periodicaly involved in various outreach activities in the media, other institutes and schools (for example BBC, Natural History museum, Sci Dev.net magazine).

Research

 Matthews research interests are broad and span transgenic technologies applied to insects and associated parasites, genetic recombination, genetic diversity, population genetics, genomics, diagnostics, transmission cycles, epidemiology, ecology, vector incrimination, drug screening, and genetic diversity of Trypanasoma cruzi and also Leishmania.

Currently Matthews primary research drive is to develop the molecular tools to interrupt transmission of vector borne diseases by transgenic modification of insect vectors using new molecular tools (CRISPR-Cas9 gene drive).

  Matthews active research lines also encompass experimental models for visceral leishmania, hybrid cell lines, diagnostics and comparative genomics. He has coordinated field research in various Latin America countries and has extensive collaborations with overseas partners.  With collaborators he was the first to produce transgenic dual fluorescent hybrids of Leishmania donovani and has developed and formalised a typing scheme (SNP-MLST) for T. cruzi. With Michael Miles and others Matthew revealed the mechanism of genetic exchange in T. cruzi in a landmark Nature paper. Other work includes the resolution of ecological, vector and host associations of T. cruzi, development of an efficient drug screening assay, improved diagnostics and the application of next generation sequencing technologies to answer fundamental phyloepidemiological questions.

Research Area
Diagnostics
Insects
Parasites
Disease control
Protozoa
Vector control
Discipline
Genetic epidemiology
Genomics
Molecular epidemiology
Cell biology
Genetics
Microbiology
Molecular biology
Parasitology
Vector biology
Disease and Health Conditions
Leishmaniasis
African trypanosomiasis
Chagas Disease
Neglected Tropical Diseases (NTDs)
Vector borne disease
Zoonotic disease
Country
Argentina
Brazil
Ecuador
United Kingdom
Guatemala
Mexico
Nicaragua
Netherlands
Peru
Portugal
Paraguay
Sweden
Venezuela, RB
Region
World

Selected Publications

Dissecting the phyloepidemiology of Trypanosoma cruzi I (TcI) in Brazil by the use of high resolution genetic markers.
Roman F; das Chagas Xavier S; Messenger LA; Pavan MG; Miles MA; Jansen AM; Yeo M
2018
PLoS neglected tropical diseases
Hosts and vectors of Trypanosoma cruzi discrete typing units in the Chagas disease endemic region of the Paraguayan Chaco.
Acosta N; López E; Lewis MD; Llewellyn MS; Gómez A; Román F; Miles MA; Yeo M
2017
Parasitology
Clinical Research on Neglected Tropical Diseases: Challenges and Solutions.
Boelaert M; NIDIAG Consortium
2016
PLoS neglected tropical diseases
Clinical and epidemiological features of leishmaniasis in northwestern-Argentina through a retrospective analysis of recent cases.
García Bustos MF; González-Prieto G; Ramos F; Mora MC; Hashiguchi Y; Parodi C; Basombrío MA; Moreno S; Monroig S; Beckar J
2015
Acta tropica
In vivo antileishmanial efficacy of miltefosine against Leishmania (Leishmania) amazonensis.
García Bustos MF; Barrio A; Prieto GG; de Raspi EM; Cimino RO; Cardozo RM; Parada LA; Yeo M; Soto J; Uncos DA
2014
The Journal of parasitology
Community-Based Sampling Methods for Surveillance of the Chagas Disease Vector, Triatoma dimidiata (Hemiptera: Reduviidae: Triatominae)
Weeks ENI; Davies C; Cordon Rosales C; Yeo M; Gezan SA; Parra-Henao G; Cameron MM
2014
Journal of medical entomology
See more Publications