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Prof Brendan Wren

Professor of Microbial Pathogenesis

United Kingdom

Tel.
02079272288

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Centre for Epidemic Preparedness and Response
Vaccine Centre
Antimicrobial Resistance Centre

Selected Publications

A combinatorial DNA assembly approach to biosynthesis of N-linked glycans in E. coli.
PASSMORE, IJ; Faulds-Pain, A; ABOUELHADID, S; HARRISON, MA; Hall, CL; Hitchen, P; Dell, A; Heap, JT; WREN, BW;
2023
Glycobiology
Engineering a suite of E. coli strains for enhanced expression of bacterial polysaccharides and glycoconjugate vaccines.
KAY, EJ; MAURI, M; WILLCOCKS, SJ; SCOTT, TA; CUCCUI, J; WREN, BW;
2022
MICROBIAL CELL FACTORIES
Development of an automated platform for the optimal production of glycoconjugate vaccines expressed in Escherichia coli.
Samaras, JJ; MAURI, M; KAY, EJ; WREN, BW; Micheletti, M;
2021
Microbial cell factories
Adaptation of host transmission cycle during Clostridium difficile speciation.
Kumar, N; Browne, HP; Viciani, E; Forster, SC; Clare, S; Harcourt, K; Stares, MD; Dougan, G; Fairley, DJ; Roberts, P; Pirmohamed, M; Clokie, MR J; Jensen, MB F; Hargreaves, KR; Ip, M; Wieler, LH; Seyboldt, C; Norén, T; Riley, TV; Kuijper, EJ; WREN, BW; Lawley, TD;
2019
NATURE GENETICS
Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen.
ABOUELHADID, S; North, SJ; Hitchen, P; Vohra, P; Chintoan-Uta, C; Stevens, M; Dell, A; CUCCUI, J; WREN, BW;
2019
mBio
A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13.
Reglinski, M; Ercoli, G; Plumptre, C; KAY, E; Petersen, FC; Paton, JC; WREN, BW; Brown, JS;
2018
NPJ vaccines
Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria.
PASSMORE, IJ; Letertre, MP M; Preston, MD; Bianconi, I; HARRISON, MA; NASHER, F; KAUR, H; Hong, HA; Baines, SD; Cutting, SM; Swann, JR; WREN, BW; DAWSON, LF;
2018
PLoS pathogens
The N-linking glycosylation system from Actinobacillus pleuropneumoniae is required for adhesion and has potential use in glycoengineering.
CUCCUI, J; TERRA, VS; Bossé, JT; Naegeli, A; ABOUELHADID, S; Li, Y; Lin, C-W; Vohra, P; Tucker, AW; Rycroft, AN; Maskell, DJ; Aebi, M; Langford, PR; WREN, BW; BRaDP1T Consortium,;
2017
Open biology
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