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Professor Brendan Wren

FRCPath

Professor
of Microbial Pathogenesis and Dean of Faculty of Infectious and Tropical Diseases

Room
Room 305b

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2288

Brendan Wren's research interests predominantly involve determining the genetic basis by which bacterial pathogens cause disease. His research group exploits a range of post genome research strategies to gain a comprehensive understanding of how these pathogens function, how they evolve and how they interact with their respective hosts.

A core interest includes studying glycosylation and glycostructures and how this relates to the survival and virulence of bacterial pathogens. An application of this basic research is the development of Protein Glycan Coupling Technology and other glycobiotechnological innovations for the production of recombinant glycoproteins. This has been applied for the development of inexpensive glycoconjugate vaccines for human and veterinary use.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Pathogen Molecular Biology

Centres

Vaccine Centre
Antimicrobial Resistance Centre

Teaching

Brendan Wren is a member of the board of examiners for the MSc in Medical Microbiology (MM) and also lectures and examines on this course.

Research

Current research focuses on:

  • Bacterial glycosylation and their role in virulence
  • Exploitation of bacterial glycosylation systems for glycoengineering towards novel antibiotic and vaccine design
  • Comparative phylogenomics and the evolution of bacterial virulence

Research on individual pathogens include; Clostridium difficileCampylobacter jejuniHelicobacter pyloriBurkholderia pseudomallei, Acinetobacter baumanniiFrancisella tularensisStreptococcus pneumonia, Streptococcus suis, Actinobacillus pleuropneumoniae, Vibrio cholerae and the enteropathogenic Yersinia.

Campylobacter Resource Facility link.

Research Area
Bacteria
Vaccines
Discipline
Genomics
Bacteriology
Genetics
Microbiology
Molecular biology
Vaccinology
Disease and Health Conditions
Diarrhoeal diseases
Infectious disease
Melioidosis
Respiratory disease
Zoonotic disease
Country
Australia
Canada
Gambia, The
Thailand
Tanzania
Vietnam
Zambia
Region
East Asia & Pacific (developing only)
Europe & Central Asia (all income levels)
South Asia
Sub-Saharan Africa (developing only)

Selected Publications

Vibrio cholerae accessory colonisation factor AcfC: a chemotactic protein with a role in hyperinfectivity.
Valiente, E. ; Davies, C. ; Mills, D.C. ; Getino, M. ; Ritchie, J.M. ; Wren, B.W. ;
2018
Sci Rep
The N-linking glycosylation system from Actinobacillus pleuropneumoniae is required for adhesion and has potential use in glycoengineering.
Cuccui, J. ; Terra, V.S. ; Bossé, J.T. ; Naegeli, A. ; Abouelhadid, S. ; Li, Y. ; Lin, C.W. ; Vohra, P. ; Tucker, A.W. ; Rycroft, A.N. ; Maskell, D.J. ; Aebi, M. ; Langford, P.R. ; Wren, B.W. ; BRaDP1T Consortium, . ;
2017
Open Biol
Role of glycosyltransferases modifying type B flagellin of emerging hypervirulent Clostridium difficile lineages and their impact on motility and biofilm formation.
Valiente, E. ; Bouché, L. ; Hitchen, P. ; Faulds-Pain, A. ; Songane, M. ; Dawson, L.F. ; Donahue, E. ; Stabler, R.A. ; Panico, M. ; Morris, H.R. ; Bajaj-Elliott, M. ; Logan, S.M. ; Dell, A. ; Wren, B.W. ;
2016
J Biol Chem
Parallel independent evolution of pathogenicity within the genus Yersinia.
Reuter, S.; Connor, T.R.; Barquist, L.; Walker, D.; Feltwell, T.; Harris, S.R.; Fookes, M.; Hall, M.E.; Petty, N.K.; Fuchs, T.M.; Corander, J.; Dufour, M.; Ringwood, T.; Savin, C.; Bouchier, C.; Martin, L.; Miettinen, M.; Shubin, M.; Riehm, J.M.; Laukkanen-Ninios, R.; Sihvonen, L.M.; Siitonen, A.; Skurnik, M.; Falcão, J.P.; Fukushima, H.; Scholz, H.C.; Prentice, M.B.; Wren, B.W.; Parkhill, J.; Carniel, E.; Achtman, M.; McNally, A.; Thomson, N.R.;
2014
Proc Natl Acad Sci U S A
The post-translational modification of the Clostridium difficile flagellin affects motility, cell surface properties and virulence.
Faulds-Pain, A. ; Twine, S.M. ; Vinogradov, E. ; Strong, P.C. ; Dell, A. ; Buckley, A.M. ; Douce, G.R. ; Valiente, E. ; Logan, S.M. ; Wren, B.W. ;
2014
Mol Microbiol
Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis.
Cuccui, J. ; Thomas, R.M. ; Moule, M.G. ; D'Elia, R.V. ; Laws, T.R. ; Mills, D.C. ; Williamson, D. ; Atkins, T.P. ; Prior, J.L. ; Wren, B.W. ;
2013
Open Biol
Bacterial pathogenomics
Pallen, M.J.; Wren, B.W.
2007
Nature
N-linked glycosylation in Campylobacter jejuni and its functional transfer into E-coli
Wacker, M.; Linton, D.; Hitchen, P. G.; Nita-Lazar, M.; Haslam, S. M.; North, S. J.; Panico, M.; Morris, H. R.; Dell, A.; Wren, B. W.; Aebi, M.
2002
Science
See all Professor Brendan Wren's Publications