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Dr Richard Wall

Research Fellow - Molecular Biology

United Kingdom

I completed my PhD at the University of Nottingham before starting a research position in Prof Rita Tewari’s group working in a range of areas from parasite motility to cell division using the malaria model, Plasmodium berghei. I then moved to the University of Dundee to work on mode of action studies for new antiparasitic drugs under the guidance of Dr Susan Wyllie. This combined a myriad of genetic, proteomic and bioinformatic techniques to identify the target of new treatments against parasites that cause Chagas’ disease, Leishmaniasis, Sleeping Sickness and Malaria. Currently, I work in the lab of Prof Anil Koul at LSHTM with an aim to discovery new drugs for the treatment of M. tuberculosis as well as investigating the underlying biology surrounding key drug targets.

A full list of publications can be found on Google Scholar.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Research

Research Area
Bacteriology
Genetics
Microbiology
Molecular biology
Parasitology
Disease and Health Conditions
Tuberculosis
Chagas disease
Leishmaniasis
African trypanosomiasis
Malaria

Selected Publications

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
Cleghorn, LA T; WALL, RJ; Albrecht, S; MacGowan, SA; Norval, S; De Rycker, M; Woodland, A; Spinks, D; Thompson, S; Patterson, S; Corpas Lopez, V; Dey, G; Collie, IT; Hallyburton, I; Kime, R; Simeons, FR C; Stojanovski, L; Frearson, JA; Wyatt, PG; Read, KD; Gilbert, IH; Wyllie, S;
2023
ACS Publications
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Cleghorn, LA T; WALL, RJ; Albrecht, S; MacGowan, SA; Norval, S; De Rycker, M; Woodland, A; Spinks, D; Thompson, S; Patterson, S; Corpas Lopez, V; Dey, G; Collie, IT; Hallyburton, I; Kime, R; Simeons, FR C; Stojanovski, L; Frearson, JA; Wyatt, PG; Read, KD; Gilbert, IH; Wyllie, S;
2023
Journal of medicinal chemistry
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
Milne, R; Wiedemar, N; Corpas-Lopez, V; Moynihan, E; WALL, RJ; Dawson, A; Robinson, DA; Shepherd, SM; Smith, RJ; Hallyburton, I; Post, JM; Dowers, K; Torrie, LS; Gilbert, IH; Baragaña, B; Patterson, S; Wyllie, S;
2022
ACS infectious diseases
Non-canonical endogenous expression of voltage-gated sodium channel NaV 1.7 subtype by the TE671 rhabdomyosarcoma cell line.
Ngum, NM; Aziz, MY A; Mohammed Latif, L; WALL, RJ; Duce, IR; Mellor, IR;
2022
The Journal of physiology
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
Smith, A; WALL, RJ; Patterson, S; Rowan, T; Rico Vidal, E; Stojanovski, L; Huggett, M; Hampton, SE; Thomas, MG; Corpas Lopez, V; Gillingwater, K; Duke, J; Napier, G; Peter, R; Vitouley, HS; Harrison, JR; Milne, R; Jeacock, L; Baker, N; Davis, SH; Simeons, F; Riley, J; Horn, D; Brun, R; Zuccotto, F; ... Gilbert, IH.
2022
Journal of medicinal chemistry
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
Mowbray, CE; Braillard, S; Glossop, PA; Whitlock, GA; Jacobs, RT; Speake, J; Pandi, B; Nare, B; Maes, L; YARDLEY, V; Freund, Y; WALL, RJ; Carvalho, S; Bello, D; Van den Kerkhof, M; Caljon, G; Gilbert, IH; Corpas-Lopez, V; Lukac, I; Patterson, S; Zuccotto, F; Wyllie, S;
2021
Journal of Medicinal Chemistry
Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease.
Lima, ML; Tulloch, LB; Corpas-Lopez, V; Carvalho, S; WALL, RJ; Milne, R; Rico, E; Patterson, S; Gilbert, IH; Moniz, S; MacLean, L; Torrie, LS; Morgillo, C; Horn, D; Zuccotto, F; Wyllie, S;
2021
Antimicrobial agents and chemotherapy
Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series.
Van den Kerkhof, M; Leprohon, P; Mabille, D; Hendrickx, S; Tulloch, LB; WALL, RJ; Wyllie, S; Chatelain, E; Mowbray, CE; Braillard, S; Ouellette, M; Maes, L; Caljon, G;
2021
Microorganisms
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Paradela, LS; WALL, RJ; Carvalho, S; Chemi, G; Corpas-Lopez, V; Moynihan, E; Bello, D; Patterson, S; Güther, ML S; Fairlamb, AH; Ferguson, MA J; Zuccotto, F; Martin, J; Gilbert, IH; Wyllie, S;
2021
Cell Chemical Biology
Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission.
Guttery, DS; Pandey, R; Ferguson, DJ; WALL, RJ; Brady, D; Gupta, D; Holder, AA; Tewari, R;
2020
Life science alliance
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