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Dr Richard Wall

Assistant Professor

London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Richard leads the TB Drug Discovery Group at LSHTM, an interdisciplinary team including experts in target deconvolution, genetic manipulation, zebrafish infection models and metabolomics. Our group supports the development of new treatments for tuberculosis (TB), investigates the mode of action of novel compounds and explores the underlying biology of emerging therapeutic targets.

 

Richard completed his PhD at the University of Nottingham (2012) before joining Prof Rita Tewari’s group, where he studied parasite motility and cell division in the malaria model Plasmodium berghei. He then moved to the University of Dundee (2015) to work with Dr Susan Wyllie on mode of action studies for antiparasitic compounds. There, he used a combination of genetic, proteomic, and bioinformatic tools to identify drug targets for diseases including Chagas’ disease, Leishmaniasis, Sleeping Sickness, and Malaria.

 

He now applies many of these same skills and methodologies to TB research. After joining the lab of Prof Anil Koul at LSHTM (2022), he began contributing to early-stage TB drug discovery, in close collaboration with our industrial partner, and now leads the programme. His group's goal is to advance the development of shorter, safer, and more effective treatments for TB by identifying new drug targets and supporting the progression of promising compounds. He currently co-supervises two PhD students.

 

He currently holds a dual affiliation with LSHTM and the Ineos Oxford Institute at the University of Oxford.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

TB Centre
Antimicrobial Resistance Centre

Teaching

Richard regularly supervises lab-based summer project students and is a personal tutor for the MSc Medical Microbiology course. He is also co-module organiser for the Novel Drug Discovery & AMR (3169) MSc module, where he leads lab practicals and the group tutorials.

Research

Richard's primary research objective is driving various TB drug discovery projects in close collaboration with our industry partner. His other interests include using saturation mutagenesis to identify resistance-conferring mutations, the impact of target overexpression in drug resistance and drug target deconvolution of phenotypic hit compounds.
Research Area
Bacteriology
Genetics
Microbiology
Molecular biology
Parasitology
Drug discovery and development
Disease and Health Conditions
Tuberculosis
Chagas disease
Leishmaniasis
African trypanosomiasis
Malaria

Selected Publications

Menaquinone depletion resensitises bedaquiline-resistant tuberculosis.
Wetzel, J; Dallow, J; Davis, E; Pearson, WH; Daems, S; Govaerts, M; Hereijgers, J; Sprangers, J; Truebody, B; Maes, V; Van Hasselt, V; Leemans, A; Pujari, V; Vos, A; Viturro, CM M; Gómez, JE; Peeters, M; Gerber, M; Chhabra, N; Wouters, A; Everaerts, M; Painter, H; Fathima, R; Willcocks, SJ; Davies, C; ... Koul, A.
2026
bioRxiv
PurFect timing: revisiting purine metabolism for tuberculosis treatment.
WALL, RJ; Mizrahi, V; Lamprecht, DA;
2025
Trends in microbiology
The role of cytochrome bc1 inhibitors in future tuberculosis treatment regimens.
Aguilar-Pérez, C; Lenaerts, AJ; Villellas, C; Guillemont, J; DALLOW, J; PAINTER, H; Ammerman, NC; Hassan, A; Golovkine, G; Brock, L; Sordello, S; Chauffour, A; Aubry, A; Mai, TC; Wong, S; CLARK, TG; Nam, K; Kim, J; Choi, J; Crabbe, M; Esquivias, J; Lounis, N; Stoops, B; Amssoms, K; Bartolome-Nebreda, JM; ... Lamprecht, DA.
2025
Nature communications
Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
Tulloch, LB; Tawell, H; Taylor, AE; Lima, ML; Dawson, A; Carvalho, S; WALL, RJ; Corpas-Lopez, V; Dey, G; Duggan, J; Magalhaes, LG; Torrie, LS; Frame, L; Robinson, D; Patterson, S; Tinti, M; Weaver, GW; Robinson, WJ; Cal, M; Kaiser, M; Mäser, P; Sjö, P; Perry, B; KELLY, JM; FRANCISCO, AF; ... Wyllie, S.
2025
Science Translational Medicine
Targeting de novo purine biosynthesis for tuberculosis treatment.
Lamprecht, DA; WALL, RJ; Leemans, A; Truebody, B; Sprangers, J; Fiogbe, P; Davies, C; Wetzel, J; Daems, S; PEARSON, W; Pillay, V; Saylock, S; Ricketts, MD; Davis, E; Huff, A; Grell, T; Lin, S; Gerber, M; Vos, A; DALLOW, J; WILLCOCKS, SJ; Roubert, C; Sans, S; Desorme, A; Chappat, N; ... KOUL, A.
2025
Nature
An open-access dashboard to interrogate the genetic diversity of Mycobacterium tuberculosis clinical isolates.
PHELAN, J; Van den Heede, K; Masyn, S; Verbeeck, R; CLARK, TG; Lamprecht, DA; KOUL, A; WALL, RJ;
2024
Scientific reports
Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.
Trenaman, A; Tinti, M; WALL, RJ; Horn, D;
2024
Nature communications
ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium.
WALL, RJ; MacGowan, SA; Hallyburton, I; Syed, AJ; Ajay Castro, S; Dey, G; Milne, R; Patterson, S; PHELAN, J; Wiedemar, N; Wyllie, S;
2024
mBio
Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.
Tulloch, LB; Tinti, M; WALL, RJ; Weidt, SK; Corpas-Lopez, V; Dey, G; Smith, TK; Fairlamb, AH; Barrett, MP; Wyllie, S;
2024
PLoS pathogens
Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation
Zhang, N; Samad, A; Zahedifard, F; WALL, R; Horn, D; Zoltner, M; Field, M;
2024
bioRxiv
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