Close

Miss Hristina Vasileva

Research Student - MPhil/PhD - Infectious & Tropical Diseases

Medical Research Council The Gambia Unit
Atlantic blvd.
Banjul
Gambia

I have completed an undergraduate degree in BSc Biological Sciences at University of Brighton and a postgraduate degree in MSc Medical Microbiology at LSHTM. I am currently a staff PhD student researching neglected protein families in relation to host immune response to malaria infection by Plasmodium falciparum. I am based between LSHTM, London and MRC Unit The Gambia.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Teaching

Distance learning tutor on IDM102: Principles of Biochemistry (2021-2023)

- Lecturing

- Mentoring

- Exam Marking

Summer project supervisors: MSc Immunology of Infectious Diseases

- Project creation

- Practical teaching in the wet lab and bioinformatic analysis

- Dissertation feedback and shaping

Research

I am currently a PhD student, researching neglected hypervariable protein families of the Plasmodium falciparum malaria parasite. My research includes characterisation of these protein families both, biochemically in the wet laboratory and bioinformatically looking at protein sequence data. I am further interested in the human host immune response to malaria infection, by looking at antibody titres against recombinant Plasmodium falciparum proteins, investigating individuals from various sub-Saharan Africa settings with variable disease and demographic profiles. Moreover, I am aiming to investigate if massive drug administration interventions have an effect to protein recognition and antibody positivity and if serosurveillance using these novel tools can be used as a proxy to malaria transmission in a population level.

I am also working as a molecular biology Research Assistant, based in the MRC Unit The Gambia @ LSHTM, working on a double-blinded cross sectional massive drug administration clinical trial, looking on the effect of Ivermectin to the reduction of malaria transmission and subsequent disease incidence in the Bijagos Archipelago of Guinea Bissau (MATAMAL).

Research Area
Immunology
Bacteriology
Molecular biology
Bioinformatics
Parasitology
Disease and Health Conditions
Trachoma
Malaria
Country
Gambia
Guinea-Bissau
Uganda
United Kingdom
Region
Sub-Saharan Africa (developing only)

Selected Publications

Genomic surveillance of Anopheles mosquitoes on the Bijagós Archipelago using custom targeted amplicon sequencing identifies mutations associated with insecticide resistance.
MOSS, S; Pretorius, E; Ceesay, S; HUTCHINS, H; Da Silva, ET; NDIATH, MO; JONES, RT; VASILEVA, H; PHELAN, J; Acford-Palmer, H; COLLINS, E; Rodrigues, A; Krishna, S; CLARK, TG; LAST, A; CAMPINO, S;
2024
Parasites & vectors
Novel hypervariable erythrocyte surface expressed recombinant proteins show promise as serological markers of exposure to<i>Plasmodium falciparum</i>infection
VASILEVA, H; Chopo-Pizarro, A; OOKO, M; Dumont, E; Wu, L; Ssewanyana, I; LAST, A; TETTEH, KK A;
2023
Cold Spring Harbor Laboratory
Prevalence of five treatable sexually transmitted infections among women in Lower River region of The Gambia.
BUTCHER, R; JARJU, S; Obayemi, D; BASHORUN, AO; VASILEVA, H; Bransbury-Hare, H; Agboghoroma, O; Drammeh, L; HOLLAND, M; HARDING-ESCH, E; CLARKE, E;
2023
BMC infectious diseases
Protocol for a cluster randomised placebo-controlled trial of adjunctive ivermectin mass drug administration for malaria control on the Bijagós Archipelago of Guinea-Bissau: the MATAMAL trial.
HUTCHINS, H; BRADLEY, J; PRETORIUS, E; Teixeira da Silva, E; VASILEVA, H; JONES, RT; NDIATH, MO; Dit Massire Soumare, H; MABEY, D; Nante, EJ; Martins, C; LOGAN, JG; Slater, H; DRAKELEY, C; D'ALESSANDRO, U; Rodrigues, A; LAST, AR;
2023
BMJ open
Population dynamics and drug resistance mutations in Plasmodium falciparum on the Bijagós Archipelago, Guinea-Bissau.
MOSS, S; Mańko, E; VASILEVA, H; Da Silva, ET; Goncalves, A; OSBORNE, A; PHELAN, J; Rodrigues, A; Djata, P; D'ALESSANDRO, U; MABEY, D; Krishna, S; LAST, A; CLARK, TG; CAMPINO, S;
2023
Scientific reports
Effects of ivermectin mass drug administration for malaria vector control on ectoparasites and soil-transmitted helminths: a cluster randomized trial.
KOSITZ, C; Drammeh, M; VASILEVA, H; Houghton, J; Ashall, J; D'ALESSANDRO, U; MARKS, M; BRADLEY, J;
2022
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
The Epidemiology of Plasmodium falciparum Malaria in the Bijagos Islands of Guinea-Bissau.
McGregor, D; Texeira da Silva, E; GRIGNARD, L; Goncalves, A; VASILEVA, H; MABEY, D; LAST, A;
2021
The American journal of tropical medicine and hygiene
Viability PCR shows that non-ocular surfaces could contribute to transmission of Chlamydia trachomatis infection in trachoma.
Versteeg, B; VASILEVA, H; HOUGHTON, J; LAST, A; SHAFI ABDURAHMAN, O; Sarah, V; MACLEOD, D; Solomon, AW; HOLLAND, MJ; Thomson, N; BURTON, MJ;
2020
PLOS NEGLECTED TROPICAL DISEASES
Prevalence of and risk factors for curable sexually transmitted infections on Bubaque Island, Guinea Bissau.
Cowley, G; Milne, G; Teixeira da Silva, E; Nakutum, J; Rodrigues, A; VASILEVA, H; MABEY, D; Versteeg, B; LAST, A;
2020
Sexually transmitted infections
Optimisation and standardisation of a multiplex immunoassay of diverse Plasmodium falciparum antigens to assess changes in malaria transmission using sero-epidemiology
Wu, L; Hall, T; Ssewanyana, I; Oulton, T; PATTERSON, C; VASILEVA, H; Singh, S; Affara, M; Mwesigwa, J; Correa, S; Bah, M; D'ALESSANDRO, U; Sepúlveda, N; DRAKELEY, C; Tetteh, K;
2020
Wellcome open research
See more information