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Dr James Thomas

Research Fellow

United Kingdom

Jump to: Affiliations Teaching Research Publications
James Thomas is a molecular geneticist in the laboratory of Dr Rob Moon. He works on understanding the basic biology of the human malaria parasites Plasmodium falciparum and Plasmodium knowlesi. He has studied invasion of, and egress from, red blood cells by the malaria parasite and has a continued interest in this field of study. Currently he works on understanding gametocytogenesis in Plasmodium knowlesi: the commitment of the malaria parasite to development of the sexual stages of its lifecycle which are required for transmission from humans to the mosquito vector.

Affiliations
Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Teaching

James take a lead role in the teaching of both the dry and wet laboratory sessions within the 3158 Advanced Training in Molecular Biology module at LSHTM.

Research
Research Area
Cell biology
Biochemistry
Molecular biology
Parasitology
Disease and Health Conditions
Malaria
Country
United Kingdom

Selected Publications
Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites.
Hart, MN; Mohring, F; DONVITO, SM; THOMAS, JA; Muller-Sienerth, N; Wright, GJ; Knuepfer, E; Saibil, HR; MOON, RW;
2023
Nature communications
Sequences of oligonucleotides and other synthetic DNA used in this study
Ramaprasad, A; Burda, P-C; Koussis, K; THOMAS, J; Pietsch, E; Calvani, E; Howell, SA; MacRae, JI; Snijders, AP; Gilberger, T-W; BLACKMAN, MJ;
2023
PLOS Pathogens
A malaria parasite phospholipase facilitates efficient asexual blood stage egress.
Ramaprasad, A; Burda, P-C; Koussis, K; THOMAS, JA; Pietsch, E; Calvani, E; Howell, SA; MacRae, JI; Snijders, AP; Gilberger, T-W; BLACKMAN, MJ;
2023
PLoS pathogens
Label-free quantitation of proteins detected in SUB1-null schizonts in the presence or absence of C2
Ramaprasad, A; Burda, P-C; Koussis, K; THOMAS, JA; Pietsch, E; Calvani, E; Howell, SA; MacRae, JI; Snijders, AP; Gilberger, T-W; BLACKMAN, MJ;
2023
PLOS Pathogens
Raw peak intensities of various lipid species measured before and after egress in RAP-treated (+RAP) and mock-treated (-RAP) LCAT:2loxPint parasites
Ramaprasad, A; Burda, P-C; Koussis, K; THOMAS, JA; Pietsch, E; Calvani, E; Howell, SA; MacRae, JI; Snijders, AP; Gilberger, T-W; BLACKMAN, MJ;
2023
PLOS Pathogens
Raw peak intensities of various lipid species measured in LCAT:2loxPint egress-stalled schizonts following mock-or RAP-treatment at ring stages
Ramaprasad, A; Burda, P-C; Koussis, K; THOMAS, JA; Pietsch, E; Calvani, E; Howell, SA; MacRae, JI; Snijders, AP; Gilberger, T-W; BLACKMAN, MJ;
2023
PLOS Pathogens
Unravelling the role of the apical membrane antigen-1 cytoplasmic domain during Plasmodium merozoite invasion of erythrocytes
THOMAS, J; Hart, M; Mayville, E; MOON, R;
2023
BioMalPar XIX
Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites
Hart, M; Mohring, F; DONVITO, S; THOMAS, J; Muller-Sienerth, N; Wright, G; Knuepfer, E; Saibil, H; MOON, R;
2022
bioRxiv
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.
Tan, MS Y; Koussis, K; Withers-Martinez, C; Howell, SA; THOMAS, JA; Hackett, F; Knuepfer, E; Shen, M; Hall, MD; Snijders, AP; BLACKMAN, MJ;
2021
The EMBO journal
Use of a highly specific kinase inhibitor for rapid, simple and precise synchronization of Plasmodium falciparum and Plasmodium knowlesi asexual blood-stage parasites.
Ressurreição, M; THOMAS, JA; Nofal, SD; FLUECK, C; MOON, RW; BAKER, DA; VAN OOIJ, C;
2020
PloS one
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James Thomas

Contact

United Kingdom