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Dr Martin Taylor

BSc PhD

Associate Professor
of Molecular Biology

Room
Room 394

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
02079588245

Martin did his PhD in the laboratory of Prof.Michael Miles at the LSHTM on the trypanothione reductase of Leishmania donovani. He then spent three years as a post-doc in Prof. Piet Borst's lab at the Netherlands Cancer Institute where he worked on antigenic variation and technology development in African trypanosomes. He returned to the School in 1995 to join Dr John Kelly's group working on the American trypanosome, Trypanosoma cruzi.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Pathogen Molecular Biology

Centres

Antimicrobial Resistance Centre

Teaching

Martin is a member of the course committee and deputy chair of the exam board for the MSc. in Molecular Biology of Infectious Diseases. Martin is the organiser for Module 3131 Molecular Biology and Recombinant DNA Techniques

Martin lectures on general control of gene expression, RNA interference/CRISPR (biology and technology), Cell biology of invasion and immune evasion by T. cruzi and Leishmania, Trypanosomatid molecular biology and the immunology of African and American Trypanosomiases.

Research

Martin's main interest is in the interaction of trypanosomes with the mammalian host, including the acquisition of essential micronutrients such as vitamins and minerals. He is currently investigating iron transport and metabolism in T. brucei and T. cruzi. He is developing methods to look at the way in which these parasites respond when the host immune system triggers its iron sequestration response. Iron is essential to these pathogens and its acquisition is likely to be a target for chemotherapy.

He is also investigating the local immunological response to infected cells in the chronic stage of T. cruzi infection in the mouse model using dual reporter parasite lines.

He is  involved in the creation of models for drug development in Stage II African trypanosomiasis, Chagas disease and visceral Leishmaniasis. This has involved the engineering of parasite lines expressing very high levels of firefly luciferase. Use of  red-shifted luciferase has led to a highly sensitive infection model which is being used to streamline in vivo drug development for these neglected tropical diseases. He has developed a combined bioluminescence/fluorescence model for investigating the pathogenesis and immunology of Chagas disease which allows the investigation of host-parasite interactions within the chronic stage. He is currently extending this system to Leishmaniasis.

Martin has also developed a tetracycline based inducible expression system for T. cruzi which is now being used in several laboratories worldwide.

Research Area
Drug discovery and development
Drug resistance
Innate immunity
Micronutrients
Parasites
Trypanosomes
Chemotherapy
Protozoa
Discipline
Genomics
Immunopathology
Biochemistry
Cell biology
Genetics
Immunology
Microbiology
Molecular biology
Parasitology
Pathology
Disease and Health Conditions
Infectious disease
Leishmaniasis
African trypanosomiasis
Chagas Disease
Neglected Tropical Diseases (NTDs)
Region
World

Selected Publications

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Lewis, M.D. ; Francisco, A.F. ; Taylor, M.C. ; Jayawardhana, S. ; Kelly, J.M. ;
2016
Cell Microbiol
The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence.
Taylor, M.C. ; Lewis, M.D. ; Francisco, A.F. ; Wilkinson, S.R. ; Kelly, J.M. ;
2015
PLoS Negl Trop Dis
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
Lewis, M.D.; Fortes Francisco, A.; Taylor, M.C.; Burrell-Saward, H.; McLatchie, A.P.; Miles, M.A.; Kelly, J.M.;
2014
Cell Microbiol
Highly Sensitive In Vivo Imaging of Trypanosoma brucei Expressing "Red-Shifted" Luciferase
McLatchie, A.P.; Burrell-Saward, H.; Myburgh, E.; Lewis, M.D.; Ward, T.H.; Mottram, J.C.; Croft, S.L.; Kelly, J.M.; Taylor, M.C.
2013
PLoS Negl Trop Dis
Genetic Techniques in Trypanosoma cruzi.
Taylor, M.C. ; Huang, H. ; Kelly, J.M. ;
2011
Adv Parasitol
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Wilkinson, S.R.; Taylor, M.C.; Horn, D.; Kelly, J.M.; Cheeseman, I.;
2008
Proc Natl Acad Sci U S A
See all Dr Martin Taylor's Publications