Sedona's main research interest is in the economic impact of substantial long-term health shocks, both at the provider level and within the household. Her research to date has been focused on measurement and understanding of the costs of chronic illness – including HIV, TB, chronic non-communicable diseases, and HCV.

Sedona's current research projects include:

TB PRACTECAL: a phase II/III clinical research project to find short, tolerable and effective treatments for people with drug-resistant tuberculosis (DR-TB)
XACT-III: a pragmatic, multi-country, open-labelled, randomised controlled trial to evaluate a scalable active case finding intervention for TB using a point-of-care molecular tool
FEND-TB: a global research consortium supporting the evaluation of early-stage TB diagnostics & novel diagnostic strategies in the context of existing clinical algorithms in TB endemic countries
iHOST: an intervention that aims to improve hospital care for people who use opioids by removing barriers to opioid withdrawal management.
TB MAC: the TB Modelling and Analysis Consortium

Past involvement in research projects includes:
VALUE-TB: a collaboration between LSHTM, University of Cape Town, and WHO aiming to collect cost data to facilitate decision-making for TB in five countries (incl. Kenya, Ethiopia, Philippines, India, and Georgia)
the Global Health Cost Consortium: which aims to mitigate the TB and HIV epidemics by systematically improving the availability, quality, timing, relevance, interpretation, and use of cost information on HIV and tuberculosis (TB) programs and services
the Integra Initiative: an analysis of integrated HIV and sexual and reproductive health services in Kenya and Swaziland
the Health Systems Chronic Disease project: a project aiming to improve the health systems response to chronic disease in Uganda and Tanzania
a project assessing the impact and cost-effectiveness of needle/syringe provision on hepatitis C transmission among people who inject drugs in the UK
the MERGE project: evaluating a model of scaling-up in