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Dr William Stone

Assistant Professor

United Kingdom

Jump to: Affiliations Teaching Research Publications

I am an Assistant Professor of malaria research. My primary work has been in Kenya, Burkina Faso, and Mali, where I have conducted various projects aiming to understand the factors that shape the infectious reservoir of malaria parasites in endemic populations, and explore strategies for targeting this population to reduce transmission and disease.

Affiliations
Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Teaching

I teach theoretical and laboratory immunology on the Immunology of Infectious Diseases MSc, and malaria immunology on the Parasite Immunology Module (3177). I also teach biostatistics and epidemiological principles on the Analysis and Design of Research Studies course in Term 1.

Research

Methodologies

  • Serological assay development, biomarker discovery, and immunoepidemiology
  • Gametocyte bioinformatics, transmission-proxy assay development, quantification, and sex-ratios
  • Mosquito feeding assay development, with a focus on the biology of common transmission metrics and improving scalability
  • ELISA, Luminex and Protein microarray platforms for immunology 

Transmission biology and Interventions

  • Transmission-blocking drug evaluation in the lab and field, with a focus on primaquine and tafenoquine
  • Sexual-stage immunology, transmission-blocking vaccine discovery
  • Cluster-randomised trials to evaluate the efficacy of transmission-focused interventions
  • Whole population assessments of the infectious reservoir, considering human, parasite and vector effectors
  • Seasonal-malaria chemoprophylaxis as a tool to target the infectious reservoir
  • Novel mosquito ectocides and endectocides
  • Sexual stage monoclonal antibodies as a transmission blocking therapy
Research Area
Disease control
Immunisation
Medicines
Parasites
Vaccines
Epidemiology
Immunology
Microbiology
Parasitology
Vaccinology
Disease and Health Conditions
Malaria
Country
Mali
Uganda
Burkina Faso
Gambia
Ethiopia
Region
Sub-Saharan Africa (all income levels)
Sub-Saharan Africa (developing only)

Selected Publications
The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections.
De Jong, RM; Alkema, M; Oulton, T; Dumont, E; Teelen, K; Nakajima, R; De Assis, RR; Press, KW D; Ngotho, P; TETTEH, KK A; Felgner, P; Marti, M; Collins, KA; DRAKELEY, C; Bousema, T; STONE, WJ R;
2022
Frontiers in immunology
Single low-dose tafenoquine combined with dihydroartemisinin-piperaquine to reduce Plasmodium falciparum transmission in Ouelessebougou, Mali: a phase 2, single-blind, randomised clinical trial.
STONE, W; Mahamar, A; Smit, MJ; Sanogo, K; Sinaba, Y; Niambele, SM; Sacko, A; Keita, S; Dicko, OM; Diallo, M; Maguiraga, SO; Samake, S; Attaher, O; Lanke, K; Ter Heine, R; BRADLEY, J; McCall, MB B; Issiaka, D; Traore, SF; Bousema, T; DRAKELEY, C; Dicko, A;
2022
The Lancet Microbe
No time to die: An in-depth analysis of James Bond's exposure to infectious agents.
Graumans, W; STONE, WJ R; Bousema, T;
2021
Travel medicine and infectious disease
Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections.
Barry, A; BRADLEY, J; STONE, W; Guelbeogo, MW; Lanke, K; Ouedraogo, A; Soulama, I; Nébié, I; Serme, SS; GRIGNARD, L; PATTERSON, C; Wu, L; Briggs, JJ; Janson, O; Awandu, SS; Ouedraogo, M; Tarama, CW; Kargougou, D; Zongo, S; Sirima, SB; Marti, M; DRAKELEY, C; Tiono, AB; Bousema, T;
2021
Nature communications
Pyronaridine-artesunate or dihydroartemisinin-piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial.
STONE, W; Mahamar, A; Sanogo, K; Sinaba, Y; Niambele, SM; Sacko, A; Keita, S; Youssouf, A; Diallo, M; Soumare, HM; KAUR, H; Lanke, K; Ter Heine, R; BRADLEY, J; Issiaka, D; Diawara, H; Traore, SF; Bousema, T; DRAKELEY, C; Dicko, A;
2021
The Lancet Microbe
Naturally acquired immunity against immature Plasmodium falciparum gametocytes.
Dantzler, KW; Ma, S; Ngotho, P; STONE, WJ R; Tao, D; Rijpma, S; De Niz, M; Nilsson Bark, SK; Jore, MM; Raaijmakers, TK; Early, AM; Ubaida-Mohien, C; Lemgruber, L; Campo, JJ; Teng, AA; Le, TQ; Walker, CL; Hermand, P; Deterre, P; Davies, DH; Felgner, P; Morlais, I; Wirth, DF; Neafsey, DE; Dinglasan, RR; ... Marti, M.
2019
SCIENCE TRANSLATIONAL MEDICINE
Two-Faced Immunity? The Evidence for Antibody Enhancement of Malaria Transmission.
STONE, W; Bousema, T; Sauerwein, R; DRAKELEY, C;
2018
Trends in parasitology
Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density.
BRADLEY, J; STONE, W; Da, DF; Morlais, I; Dicko, A; Cohuet, A; Guelbeogo, WM; Mahamar, A; Nsango, S; Soumaré, HM; Diawara, H; Lanke, K; Graumans, W; Siebelink-Stoter, R; Van de Vegte-Bolmer, M; Chen, I; Tiono, A; GONÇALVES, BP; GOSLING, R; Sauerwein, RW; DRAKELEY, C; Churcher, TS; Bousema, T;
2018
eLife
A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance.
STONE, W; Sawa, P; Lanke, K; Rijpma, S; Oriango, R; Nyaurah, M; Osodo, P; Osoti, V; Mahamar, A; Diawara, H; Woestenenk, R; Graumans, W; Van de Vegte-Bolmer, M; BRADLEY, J; Chen, I; Brown, J; Siciliano, G; Alano, P; GOSLING, R; Dicko, A; DRAKELEY, C; Bousema, T;
2017
The Journal of infectious diseases
Naturally acquired immunity to sexual stage P. falciparum parasites.
STONE, WJ R; Dantzler, KW; Nilsson, SK; DRAKELEY, CJ; Marti, M; BOUSEMA, T; Rijpma, SR;
2016
Parasitology
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William Stone

Contact

United Kingdom