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Dr Anton Spadar

Research Fellow

United Kingdom

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Research

My works focuses on the way data science can inform design and analysis of laboratory work. My current project is development and validation of PCR amplicon panel for environmental surveillance of Salmonella enterica serovar Typhi. Prior to this, I have investigated biomarkers of hypervirulence in Klebsiella pneumoniae and the relationship between this bacteria's carbapenemase resistance and hypervirulence phenotypes. In parallel, I have also continued my MSc work on Aedes mosquitoes investigating the origin chromosomally integrated DNA from non-retroviral RNA viruses and also creating a catalogue of possible resistance mutations in Aedes aegypti mosquitoes.

In addition to this work, I am pursuing other projects including AI assisted development of novel anti-TB drugs and application of amplicons in understanding of UK tick-borne infections and management of plant pests.

Selected Publications

Diversity, functional classification and genotyping of SHV β-lactamases in<i>Klebsiella pneumoniae</i>
Tsang, K; Lam, MM C; Wick, R; Wyres, K; Bachman, M; Baker, S; Barry, K; Brisse, S; Campino, S; Chiaverini, A; Cirillo, DM; CLARK, T; Corander, J; Corbella, M; Cornacchia, A; Cuénod, A; D’Alterio, N; Di Marco, F; Donado-Godoy, P; Egli, A; Farzana, R; Feil, E; Fostervold, A; Gorrie, C; Gütlin, Y; ... KlebNET AMR Genotype-Phenotype Group,
2024
bioRxiv
Genome-wide genetic variation and molecular surveillance of drug resistance in Plasmodium falciparum isolates from asymptomatic individuals in Ouélessébougou, Mali.
VANHEER, LN; Mahamar, A; Manko, E; Niambele, SM; Sanogo, K; Youssouf, A; Dembele, A; Diallo, M; Maguiraga, SO; PHELAN, J; OSBORNE, A; SPADAR, A; Smit, MJ; Bousema, T; DRAKELEY, C; CLARK, TG; STONE, W; Dicko, A; CAMPINO, S;
2023
Scientific reports
Identification of two insecticide resistance markers in Ethiopian Anopheles stephensi mosquitoes using a multiplex amplicon sequencing assay.
Acford-Palmer, H; PHELAN, JE; Tadesse, FG; KRISTAN, M; COLLINS, E; SPADAR, A; Walker, T; Bousema, T; MESSENGER, LA; CLARK, TG; CAMPINO, S;
2023
Scientific reports
Emergence of KPC-3- and OXA-181-producing ST13 and ST17 Klebsiella pneumoniae in Portugal: genomic insights on national and international dissemination.
Elias, R; SPADAR, A; Hendrickx, AP A; Bonnin, RA; Dortet, L; Pinto, M; PHELAN, JE; Portugal, I; CAMPINO, S; Da Silva, GJ; CLARK, TG; Duarte, A; Perdigão, J;
2023
The Journal of antimicrobial chemotherapy
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SPADAR, A;
2023
Population genetic analysis of Plasmodium knowlesi reveals differential selection and exchange events between Borneo and Peninsular sub-populations.
Turkiewicz, A; Manko, E; Oresegun, DR; NOLDER, D; SPADAR, A; SUTHERLAND, CJ; Cox-Singh, J; MOON, RW; Lau, Y-L; CAMPINO, S; CLARK, TG;
2023
Scientific reports
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