Dr Anna Schultze

Assistant Professor

United Kingdom

I am a pharmacoepidemiologist based in the Electronic Health Records (EHR) group researching drug and vaccine safety using large observational databases. Before joining LSHTM, I worked as an epidemiologist in the pharmaceutical industry where I led post-authorisation safety and comparative effectiveness studies, primarily using nationwide Scandinavian health registries. I completed a PhD in epidemiology at UCL in 2017, focusing on HIV drug resistance, and also hold an MSc in Epidemiology from LSHTM and a BSc in Human Sciences from UCL.


Department of Non-communicable Disease Epidemiology
Faculty of Epidemiology and Population Health


I am a module organiser for Extended Epidemiology, and teach on Basic Epidemiology, the Professional Certificate course in Pharmacoepidemiology and Introduction to Health Data Science. My teaching covers a range of topics ranging from introductory epidemiology to reproducible programming/git. I also supervise a number of MSc students.


I am broadly interested in how we can better use routinely collected data to study the effectiveness and safety of medications. My current research focuses on self-controlled study designs, specifically applied to COVID-19 vaccine safety and single-arm studies (long-term extensions of clinical trials). I have been involved in several broader studies of drug repurposing for COVID-19 and descriptive epidemiology using the OpenSAFELY platform. I'm particularly interested in reproducibility and open science, and also lead some meta-research on these practices in pharmacoepidemiology.

Research Area
Statistical methods
Research methodology

Selected Publications

VAC4EU/CVM: WP4 SCCS sensitivity code for publication/Zenodo
Messina, D; Paoletti, O; Belitser, S; Gini, RM; Limoncella, G; SCHULTZE, A;
ehr-lshtm/code-sharing: preprint
Rapid Safety Assessment of SARS-CoV-2 Vaccines in EU Member States using Electronic Health Care Data Sources (COVID Vaccine Monitor-CVM study): Final Study Report for WP3 (electronic health record data)
Durán, CE; Messina, D; Gini, R; Riefolo, F; Aragón, M; Belitser, S; Bissacco, CA; Bots, SH; De Burgos, A; Carreras-Martínez, JJ; Correcher-Martínez, E; DOUGLAS, IJ; Garcia-Poza, P; Girardi, A; Herings, R; Hoxhaj, V; Huerta, C; Hyeraci, G; Ientile, V; Ingrasciotta, Y; Limoncella, G; Lupattelli, A; Maglanoc, L; Martin, I; Martin, M; ... Sturkenboom, M.
Association between living with children, vaccination, and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England during 2021–22
COWLING, T; Forbes, H; Wing, K; TAZARE, J; SCHULTZE, A; Morton, C; Bacon, S; MacKenna, B; Walker, A; Hulme, W; Bates, C; Mehrkar, A; Curtis, H; Evans, D; Inglesby, P; Davy, S; Cockburn, J; Parry, J; Hester, F; Harper, S; Douglas, I; EVANS, S; BHASKARAN, K; WILLIAMSON, E; EGGO, R; ... TOMLINSON, L.
Wellcome Open Res
Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform.
COSTELLO, RE; Tazare, J; Piehlmaier, D; HERRETT, E; Parker, EP K; ZHENG, B; Mansfield, KE; HENDERSON, AD; CARREIRA, H; BIDULKA, P; WONG, AY S; WARREN-GASH, C; Hayes, JF; Quint, JK; MacKenna, B; Mehrkar, A; EGGO, RM; Katikireddi, SV; TOMLINSON, L; LANGAN, SM; Mathur, R; LH&W NCS (or CONVALESCENCE) Collaborative,; OpenSAFELY collaborative,;
Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2 sublineages: emulated target trials using the OpenSAFELY platform
The OpenSAFELY collaborative,; TAZARE, J; Nab, L; ZHENG, B; Hulme, W; Green, A; Curtis, H; MAHALINGASIVAM, V; Higgins, R; SCHULTZE, A; BHASKARAN, K; Mehrkar, A; Schaffer, A; Smith, R; Bates, C; Cockburn, J; Parry, J; Hester, F; Harper, S; EGGO, R; Walker, A; MARKS, M; Brown, M; MARINGE, C; LEYRAT, C; ... DOUGLAS, I.
Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data.
Hulme, WJ; WILLIAMSON, E; Horne, EM F; Green, A; McDonald, HI; Walker, AJ; Curtis, HJ; Morton, CE; MacKenna, B; Croker, R; Mehrkar, A; Bacon, S; Evans, D; Inglesby, P; Davy, S; BHASKARAN, K; SCHULTZE, A; RENTSCH, CT; TOMLINSON, L; DOUGLAS, IJ; EVANS, SJ W; SMEETH, L; Palmer, T; GOLDACRE, B; Hernán, MA; ... Sterne, JA C.
Annals of internal medicine
Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries.
Bots, SH; Riera-Arnau, J; Belitser, SV; Messina, D; Aragón, M; Alsina, E; DOUGLAS, IJ; Durán, CE; García-Poza, P; Gini, R; Herings, RM C; Huerta, C; Sisay, MM; Martín-Pérez, M; Martin, I; Overbeek, JA; Paoletti, O; Pallejà-Millán, M; SCHULTZE, A; Souverein, P; Swart, KM A; Villalobos, F; Klungel, OH; Sturkenboom, MC J M;
Frontiers in pharmacology
Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community: observational cohort study with the OpenSAFELY platform.
ZHENG, B; Green, AC A; Tazare, J; Curtis, HJ; Fisher, L; Nab, L; SCHULTZE, A; MAHALINGASIVAM, V; PARKER, EP K; Hulme, WJ; Bacon, SC J; DeVito, NJ; Bates, C; Evans, D; Inglesby, P; Drysdale, H; Davy, S; Cockburn, J; Morton, CE; Hickman, G; Ward, T; Smith, RM; Parry, J; Hester, F; Harper, S; ... TOMLINSON, LA.
BMJ (Clinical research ed.)
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