Dr Maria Ruperez


Research Fellow
of Epidemiology in HIV/TB

Keppel Street
United Kingdom

I am a medical doctor and joined the LSHTM, for the first time, in 2010 as a student of the MSc in Tropical Medicine and International Health. After the MSc I worked for three years, both as a clinician and as a clinical researcher, in Mozambique, where I led and coordinated numerous studies and trials mainly focused on HIV and malaria. I completed my PhD at the University of Barcelona in 2016, which assessed the effect of maternal malaria and HIV on infant's health in sub-Saharan Africa. I have worked for the Barcelona Institute for Global Health (ISGlobal) and, more recently, at the University of Cambridge, conducting various population-based studies in Africa. I joined LSHTM in 2018 as Research Fellow in Epidemiology of TB/HIV in the TREATS project ( 


Department of Clinical Research
Faculty of Infectious and Tropical Diseases


Maternal, Adolescent, Reproductive & Child Health (MARCH)
Tuberculosis (TB) Centre


I have worked as Teaching Fellow in the Master of Public Health at the Imperial College and have lectured and supervised MSc's dissertations in the Master of Global Health from ISGlobal-University of Barcelona. Currently I am tutor of TMIH students and I am supervising some of their summer projects. I also co-organise the AIDS module at LSHTM.


My research has been, mainly, focused on the epidemiology of HIV and malaria in sub-Saharan Africa, particularly on the impact that these two diseases and the current recommended preventive interventions have on the health women and their children. I worked in the MiPPAD trial, a multicenter randomized controlled trial to assess effectiveness and safety on MQ compared to SP in preventing malaria in pregnancy, but have also coordinated large cohort studies to assess the impact of HIV in pregnancy on  infant's morbidity and mortality and cross-sectional studies to describe patterns and trends of HIV-drug resistance on pregnant women and adults in sub-Saharan Africa. I have also worked at the Univeristy of Cambridge in several population-based research and epidemiological field studies to investigate the burden of Chronic Diseases in sub-Saharan Africa. Currently, at LSHTM I am part of the TREATS study, a multi-site project aiming to understand the impact of a combined TB/HIV intervention on TB incidence, prevalence and incidence of infection in Zambia and South Africa.

Research Area
Child health
Clinical trials
Drug resistance
Maternal health
Global Health
Implementation research
Operational research
Disease and Health Conditions
Tropical diseases
South Africa
Sub-Saharan Africa (developing only)

Selected Publications

HIV drug resistance patterns in pregnant women using next generation sequence in Mozambique.
Rupérez M; Noguera-Julian M; González R; Maculuve S; Bellido R; Vala A; Rodríguez C; Sevene E; Paredes R; Menéndez C
PloS one
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies.
Dellicour S; Sevene E; McGready R; Tinto H; Mosha D; Manyando C; Rulisa S; Desai M; Ouma P; Oneko M
PLoS medicine
Multiplexing detection of IgG against Plasmodium falciparum pregnancy-specific antigens.
Fonseca AM; Quinto L; Jiménez A; González R; Bardají A; Maculuve S; Dobaño C; Rupérez M; Vala A; Aponte JJ
PloS one
Infant mortality and morbidity associated with preterm and small-for-gestational-age births in Southern Mozambique: A retrospective cohort study.
García-Basteiro AL; Quintó L; Macete E; Bardají A; González R; Nhacolo A; Sigauque B; Sacoor C; Rupérez M; Sicuri E
PloS one
Effects of HIV infection on maternal and neonatal health in southern Mozambique: A prospective cohort study after a decade of antiretroviral drugs roll out.
González R; Rupérez M; Sevene E; Vala A; Maculuve S; Bulo H; Nhacolo A; Mayor A; Aponte JJ; Macete E
PloS one
Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities.
Ndam NT; Mbuba E; González R; Cisteró P; Kariuki S; Sevene E; Rupérez M; Fonseca AM; Vala A; Maculuve S
BMC medicine
Interferon-γ-Inducible Protein 10 (IP-10) as a Screening Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings.
Pastor L; Casellas A; Rupérez M; Carrillo J; Maculuve S; Jairoce C; Paredes R; Blanco J; Naniche D
Clinical infectious diseases
Maternal HIV infection is an important health determinant in non-HIV-infected infants.
Rupérez M; González R; Maculuve S; Quintó L; López-Varela E; Augusto O; Vala A; Nhacolo A; Sevene E; Naniche D
AIDS (London, England)
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