Dr Maria Ruperez


Assistant Professor
of Epidemiology in HIV/TB


Keppel Street
United Kingdom

I am a medical doctor and joined the LSHTM, for the first time, in 2010 as a student of the MSc in Tropical Medicine and International Health. I have worked for three years, both as a clinician and as researcher, in Mozambique, where I led and coordinated numerous studies and trials mainly focused on HIV and malaria. I completed my PhD at the University of Barcelona in 2016, which assessed the effect of maternal malaria and HIV on infant's health in sub-Saharan Africa. I have worked for the Barcelona Institute for Global Health (ISGlobal) and, more recently, at the University of Cambridge, conducting various population-based studies in Africa. I joined LSHTM in 2018 as scientific coordinator of the TREATS project, which aims to measure the impact of an HIV/TB preventive intervention in the community on the burden of TB in Zambia and South Africa ( and leading several sub-studies on TB diagnostic tools. More recently, I have been working on operational research studies on implementation of TB and COVID-19 bidirectional screening in Zambia. 


Department of Clinical Research
Faculty of Infectious and Tropical Diseases


Centre for Maternal Adolescent Reproductive & Child Health (MARCH)
TB Centre


I have worked as Teaching Fellow in the Master of Public Health at the Imperial College and have lectured and supervised MSc's dissertations in the Master of Global Health from ISGlobal-University of Barcelona. Currently at LSHTM I am deputy organiser of the HIV Module, tutor of TMIH students and supervisor of MSc summer projects. 


My research has been, mainly, focused on HIV/TB in sub-Saharan Africa. Since I joined  LSHTM in 2018 I have been coordinating scientifically the TREATS study, a multi-site project aiming to understand the impact of a combined TB/HIV intervention on TB prevalence and incidence of infection in Zambia and South Africa. Within TREATS, we have been assessing how to best measure 'active' TB in the community and in TB prevalence surveys, and comparing Xpert-Ultra and culture outcomes in this context. I have been focusing, more particularly, in the use and performance of innovative screening tools for detecting TB in the community, such as CAD4TB and CRP. Besides TREATS, I have led several studies on performance of COVID-19 rapid test and of self-testing kits, and more recently, on implementation of TB and COVID-19 bidirectional screening at health facility and community level in Zambia

Research Area
Child health
Clinical trials
Drug resistance
Maternal health
Global Health
Implementation research
Operational research
Disease and Health Conditions
Tropical diseases
South Africa
Sub-Saharan Africa (developing only)

Selected Publications

Use of point-of-care C-reactive protein testing for screening of tuberculosis in the community in high-burden settings: a prospective, cross-sectional study in Zambia and South Africa.
Ruperez M; Shanaube K; Mureithi L; Wapamesa C; Burnett MJ; Kosloff B; de Haas P; Hayes R; Fidler S; Gachie T
The Lancet. Global health
Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa.
Floyd S; Klinkenberg E; de Haas P; Kosloff B; Gachie T; Dodd PJ; Ruperez M; Wapamesa C; Burnett MJ; Kalisvaart N
BMJ Open
SARS-CoV-2 seroprevalence and associated risk factors in periurban Zambia: a population-based study.
Shanaube K; Schaap A; Klinkenberg E; Floyd S; Bwalya J; Cheeba M; de Haas P; Kosloff B; Ruperez M; Hayes R
International Journal of Infectious Diseases
HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women.
Alonso S; Vidal M; Ruiz-Olalla G; González R; Jairoce C; Manaca MN; Vázquez-Santiago M; Balcells R; Vala A; Rupérez M
The Journal of infection
Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique.
Alonso S; Vidal M; Ruiz-Olalla G; González R; Manaca MN; Jairoce C; Vázquez-Santiago M; Balcells R; Vala A; Rupérez M
Frontiers in immunology
Assessing usability of QIAreach QuantiFERON-TB platform in a high tuberculosis prevalence, low-resource setting.
Kaaba C; Ruperez M; Kosloff B; Ndunda N; Shanaube K; Ayles H
ERJ open research
See more Publications