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Prof Stuart Pocock

Professor of Medical Statistics

United Kingdom

Stuart Pocock is Professor of Medical Statistics (since 1989) at the London School of Hygiene and Tropical Medicine, a leading European centre of excellence for biostatistical research and teaching.

His primary research interest concerns clinical trials, both as regards methodological developments and applied collaboration in major trials, mainly in cardiology. He also has interests in observational epidemiology especially pharmaco-epidemiology. His particular methodological areas of expertise include: standards for the statistical reporting of trials and epidemiological studies, the statistical ethical and organisational principles for data monitoring including early stopping guidelines, the win ratio approach to a hierarchical composite of outcomes with clinical priorities, adaptive designs, handling non-proportional hazards, the value of repeat-event analyses, use and misuse of propensity scores, the pros and cons of non-inferiority trials, problems of multiplicity in trial reporting, eg, subgroup analyses, multiple outcomes and covariate adjustment, and the development/validation of prognostic risk scores.

Professor Pocock and his colleagues run a statistical centre for the design, conduct, analysis and reporting of major clinical trials, especially in cardiovascular diseases. He is also a consultant statistician for a wider range of clinical trials in which expert statistical advice is needed, and serves as a statistical member of many trial data monitoring and steering committees.

He collaborates internationally especially with the Centro Nacional de Investigaciones Cardiovasculares in Madrid, and the Cardiovascular Research Foundation and Mount Sinai School of Medicine in New York. He is a frequent lecturer on a variety of clinical trials issues, and has published over 600 articles in peer-reviewed journals, and a popular textbook “Clinical Trials: a Practical Approach”.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Centres

Centre for Data and Statistical Science for Health

Teaching

Module in Clinical Trials every Autumn

Other MSc Medical Statistics activities

PhD student supervision

Mentor to Cardiology Fellows in Madrid

Lecturing to Cardiology Fellows in Mt Sinai, NY

Research

His primary research interest concerns clinical trials, both as regards methodological developments and applied collaboration in major trials, mainly in cardiology. He also has interests in observational epidemiology especially pharmaco-epidemiology. His particular methodological areas of expertise include: standards for the statistical reporting of trials and epidemiological studies, the statistical ethical and organisational principles for data monitoring including early stopping guidelines, the win ratio approach to a hierarchical composite of outcomes with clinical priorities, adaptive designs, handling non-proportional hazards, the value of repeat-event analyses, use and misuse of propensity scores, the pros and cons of non-inferiority trials, problems of multiplicity in trial reporting, eg, subgroup analyses, multiple outcomes and covariate adjustment, and the development/validation of prognostic risk scores.

Selected Publications

Polypill Strategy in Secondary Cardiovascular Prevention.
Castellano, JM; POCOCK, SJ; Bhatt, DL; Quesada, AJ; Owen, R; Fernandez-Ortiz, A; Sanchez, PL; Marin Ortuño, F; Vazquez Rodriguez, JM; Domingo-Fernández, A; Lozano, I; Roncaglioni, MC; Baviera, M; Foresta, A; Ojeda-Fernandez, L; Colivicchi, F; Di Fusco, SA; Doehner, W; Meyer, A; Schiele, F; Ecarnot, F; Linhart, A; Lubanda, J-C; Barczi, G; Merkely, B; ... SECURE Investigators,
2022
New England Journal of Medicine
Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial.
Mahfoud, F; Kandzari, DE; Kario, K; Townsend, RR; Weber, MA; Schmieder, RE; Tsioufis, K; POCOCK, S; Dimitriadis, K; Choi, JW; East, C; D'Souza, R; Sharp, AS P; Ewen, S; Walton, A; Hopper, I; Brar, S; McKenna, P; Fahy, M; Böhm, M;
2022
Lancet (London, England)
Empagliflozin in Heart Failure with a Preserved Ejection Fraction.
Anker, SD; Butler, J; Filippatos, G; Ferreira, JP; Bocchi, E; Böhm, M; Brunner-La Rocca, H-P; Choi, D-J; Chopra, V; Chuquiure-Valenzuela, E; Giannetti, N; Gomez-Mesa, JE; Janssens, S; Januzzi, JL; Gonzalez-Juanatey, JR; Merkely, B; Nicholls, SJ; Perrone, SV; Piña, IL; Ponikowski, P; Senni, M; Sim, D; Spinar, J; Squire, I; Taddei, S; ... EMPEROR-Preserved Trial Investigators,
2021
The New England journal of medicine
Novel biomarker-driven prognostic models to predict morbidity and mortality in chronic heart failure: the EMPEROR-Reduced trial.
POCOCK, SJ; Ferreira, JP; GREGSON, J; Anker, SD; Butler, J; Filippatos, G; Gollop, ND; Iwata, T; Brueckmann, M; Januzzi, JL; Voors, AA; Zannad, F; Packer, M;
2021
European heart journal
Primary and Secondary Outcome Reporting in Randomized Trials: JACC State-of-the-Art Review.
POCOCK, SJ; Rossello, X; Owen, R; COLLIER, TJ; Stone, GW; Rockhold, FW;
2021
Journal of the American College of Cardiology
The win ratio approach for composite endpoints: practical guidance based on previous experience.
Redfors, B; GREGSON, J; Crowley, A; McAndrew, T; Ben-Yehuda, O; Stone, GW; POCOCK, SJ;
2020
European heart journal
Ticagrelor with or without aspirin following percutaneous coronary intervention in high-risk patients with concomitant peripheral artery disease: A subgroup analysis of the TWILIGHT randomized clinical trial.
Krucoff, M; Spirito, A; Baber, U; Sartori, S; Angiolillo, DJ; Briguori, C; Cohen, DJ; COLLIER, T; Dangas, G; Dudek, D; Escaned, J; Gibson, CM; Han, Y-L; Huber, K; Kastrati, A; Kaul, U; Kornowski, R; Kunadian, V; Vogel, B; Mehta, SR; Moliterno, D; Sardella, G; Shlofmitz, RA; Sharma, S; Steg, PG; ... Mehran, R.
2024
American heart journal
Carbohydrate antigen 125 concentrations across the ejection fraction spectrum in chronic heart failure: The EMPEROR programme.
Ferreira, JP; Packer, M; Sattar, N; Butler, J; POCOCK, SJ; Anker, SD; Maldonado, SG; Panova-Noeva, M; Sumin, M; Masson, S; Zannad, F; Januzzi, JL;
2024
European journal of heart failure
Empagliflozin and risk of lower respiratory tract infection in heart failure with mildly reduced and preserved ejection fraction: An EMPEROR-Preserved analysis.
Ferreira, JP; Zannad, F; Packer, M; Filippatos, G; POCOCK, SJ; Vasques-Nóvoa, F; Böhm, M; Butler, J; Anker, S;
2024
European journal of heart failure
One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial.
Sandner, S; Gaudino, M; Redfors, B; Angiolillo, DJ; Ben-Yehuda, O; Bhatt, DL; Fremes, SE; Lamy, A; Marano, R; Mehran, R; POCOCK, S; Rao, SV; Spertus, JA; Weinsaft, JW; Wells, G; Ruel, M;
2024
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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