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Professor Michael Miles

BSc MSc Phd DSc FRCPath

Professor
of Medical Protozoology

Room
Room 329b

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+ 44 20 7927 2340

The research interests of Professor Michael Miles concern: the genetic diversity and molecular genetics of protozoan parasites, particularly Trypanosoma cruzi and Leishmania species; the epidemiology and control of South American Trypanosomiasis (Chagas disease) and of visceral and cutaneous leishmaniasis; the molecular taxonomy of triatomine bugs (Hemiptera:Reduviidae); the ecology of South American mammals and developmental diagnostics for neglected tropical diseases.

Research collaborations in several South American countries, including Paraguay, Venezuela, Brazil, Colombia, Bolivia, Ecuador and in the Sudan, India and Europe. Research projects on Chagas disease and leishmaniasis. Coordinator of EC FP5, FP6 LeishEpiNetSA (12 partners) and FP7 ChagasEpiNet (15 partners); partner in FP7 NIDIAG and in H2020 Euroleish-net.

 

Affiliations

Department of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases

Centres

International Diagnostics Centre
Malaria Centre

Teaching

Founder and Course Director, MSc in the Control of Infectious Diseases (CID).

Founder MSc course in the Molecular Biology of Infectious Diseases (MBID). 

Module Organiser:

11-week core term 1 teaching for CID, and module 3125 Introduction to Infectious Disease Agents and their Control.

Tutor, PhD supervisor (over 30 previous PhD students successfully completed), MSc project supervisor.

Teaching: parasitology, molecular biology, molecular epidemiology on several internal MScs, short courses and external courses.

 

Research

Research is primarily on molecular epidemiology and taxonomy of Leishmania and Trypanosoma cruzi, improvement of control strategies, including both fundamental experimental and field research, and on diagnostics development.

Examples of research achievements (with research collaborators) include: 

Described the biochemical and genetic heterogeneity of T. cruzi (Nature publication).

Pioneered the concept of separate, overlapping and enzootic transmission cycles as applied to the epidemiology of Chagas disease.

Showed that Rhodnius prolixus in Venezuela reinvades houses (with Sinead Fitzpatrick).

Circumstantially linked distinct genotypes of T. cruzi to the diverse chronic manifestations of Chagas disease (Brazil and Venezuela; Lancet publication).

Originated the hypothesis that disinct T. cruzi lineages have broad but not exclusive evolutionary associations with arboreal and terrestrial transmission cycles - Didelphis marsupialis a predominant host of T. cruzi I and the armadillo Dasypus novemcinctus associated with T. cruzi III.

Obtained the first experimental proof of genetic exchange in T. cruzi (Nature publication).

Demonstrated that Trypanosoma rangeli is widely distributed in Brazil, and described its hosts and vectors.

Defined biochemical characters distinguishing several New World Leishmania species.

Applied comparative molecular genetics to demonstrate the synonymy of Leishmania chagasi and Leishmania infantum [with Isabel Mauricio].

Described in vitro systems to induce metacyclogenesis in Leishmania donovani and Leishmania braziliensis, showing lentil lectin to be a marker of complement resistance and infectivity [with Keith Howard].

Demonstrated that Didelphis marsupialis is a host of L. guyanensis in Amazonian Brazil (with Jorge Arias).

Described the ecotopes of several Amazonian triatomine species and explained the absence of endemic (domestic) Chagas disease in the Amazon Basin.

Discovered the new triatomine species Rhodnius paraensis from Amazon forest, and the silvatic epitope of Panstrongylus megistus in Rio de Janeiro. 

Developed spool-and-line mammal tracking for locating triatomines in animal nests and refuges and for studies of mammal ecology.

Demonstrated L. braziliensis/L. peruviana hybrids and evidence of recombination events in Viannia populations in Peru (with Debbie Nolder).

Drew attention to the global threat of visceral leishmaniasis/HIV co-infection (Nature Correspondence).

Visualisation of hybrid transgenic Leishmania in sand flies (with Sadlova, Yeo, Volf et al.)

Various genetic molecular epidemiological studies of T. cruzi (with EC ChagasEpiNet partners) and Leishmania (with EC LeishEpiNet partners).

Lineage-specific T. cruzi synthetic peptide rapid diagnostic test (with Tapan Bhattacharyya).

Compared genetic diversity of L. donovani, and levels of antibody response in visceral leishmaniasis, between India and Sudan, in the context of comparative efficacy of rapid diagnostic tests (with Tapan Bhattacharyya).

Development of a rapid serological diagnostic test to detect post-chemotherapy relapse of visceral leishmaniasis and progression from asymptomatic carrier status to active disease (with Tapan Bhattacharyya).

Research Area
Diagnostics
Parasites
Trypanosomes
Disease control
Protozoa
Vector control
Discipline
Genomics
Molecular epidemiology
Genetics
Immunology
Molecular biology
Parasitology
Vector biology
Entomology
Disease and Health Conditions
Diarrhoeal diseases
Leishmaniasis
Chagas Disease
Neglected Tropical Diseases (NTDs)
Tropical diseases
Vector borne disease
Zoonotic disease
Country
Argentina
Bolivia
Brazil
Chile
Colombia
Ecuador
Ethiopia
Guatemala
India
Mexico
Nepal
Paraguay
Sudan
United States
Venezuela, RB
Region
Latin America & Caribbean (developing only)
Middle East & North Africa (developing only)
South Asia

Selected Publications

Visualisation of Leishmania donovani fluorescent hybrids during early stage development in the sand fly vector.
Sadlova, J. ; Yeo, M. ; Seblova, V. ; Lewis, M.D. ; Mauricio, I. ; Volf, P. ; Miles, M.A. ;
PLoS One
Recent, Independent and Anthropogenic Origins of Trypanosoma cruzi Hybrids.
Lewis, M.D. ; Llewellyn, M.S. ; Yeo, M. ; Acosta, N. ; Gaunt, M.W. ; Miles, M.A. ;
PLoS Negl Trop Dis
Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection.
Llewellyn, M.S.; Miles, M.A.; Carrasco, H.J.; Lewis, M.D.; Yeo, M.; Vargas, J.; Torrico, F.; Diosque, P.; Valente, V.; Valente, S.A.; Gaunt, M.W.;
PLoS Pathog
The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future.
Miles, M.A.; Llewellyn, M.S.; Lewis, M.D.; Yeo, M.; Baleela, R.; Fitzpatrick, S.; Gaunt, M.W.; Mauricio, I.L.;
Parasitology
Molecular Genetics Reveal That Silvatic Rhodnius prolixus Do Colonise Rural Houses.
Fitzpatrick, S.; Feliciangeli, M.D.; Sanchez-Martin, M.J.; Monteiro, F.A.; Miles, M.A.;
PLoS Negl Trop Dis
Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy.
Lukes, J.; Mauricio, I.L.; Schönian, G.; Dujardin, J.C.; Soteriadou, K.; Dedet, J.P.; Kuhls, K.; Tintaya, K.W.; Jirků, M; Chocholová, E.; Haralambous, C.; Pratlong, F.; Oborník, M.; Horák, A.; Ayala, F.J.; Miles, M.A.;
Proc Natl Acad Sci U S A
Mechanism of genetic exchange in American trypanosomes
Gaunt, M. W.; Yeo, M.; Frame, I. A.; Stothard, J. R.; Carrasco, H. J.; Taylor, M. C.; Mena, S. S.; Veazey, P.; Miles, G. A.; Acosta, N.; de Arias, A. R.; Miles, M. A.
Nature
See all Professor Michael Miles's Publications