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Professor Michael Miles

BSc MSc PhD DSc FRCPath

Professor
Professor of Medical Protozoology

Room
Room 391

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+ 44 20 7927 2340

1971-1981 Wellcome-Harvard-London Scheme, seconded to Brazil. 1981-1989 Wellcome Trust Senior Lecturer. 1984-2002, Head of three successive Research Units at LSHTM. Professor of Medical Protozoology at LSHTM 1993 to present.

Principal research interests have been: genetic diversity and molecular genetics of protozoan parasites, particularly Trypanosoma cruzi and Leishmania species; the epidemiology and control of South American Trypanosomiasis (Chagas disease) and of visceral and cutaneous leishmaniasis; the molecular taxonomy of triatomine bugs (Hemiptera:Reduviidae); the ecology of South American mammals and developmental diagnostics for neglected tropical diseases, most recently including soil tranmitted helminths (STAs).

Coordination of international research collaborations: co-applicant and LSHTM coordinator for Euroleish-Net (which supported 15 early stage researchers/PhD students, 3 in LSHTM); partner in new EDCTP network (collaboration with Ethiopia, Sudan, Kenya, Uganda); PI and Coordinator of previous EC networks FP5, FP6 LeishEpiNetSA (12 partners) and FP7 ChagasEpiNet (15 partners); partner in FP7 NIDIAG.  Participant in Citizen Science Initiative for Venezuela, led by Martin Llewellyn (Glasgow). Research collaborations in several South American countries, including Argentina, Paraguay, Venezuela, Brazil, Colombia, Bolivia, Ecuador, Venezuela, and in the Sudan, India and Europe.

Chalmers Medal, Royal Society of Tropical Medicine; Grã-Cruz decoration, Ministry of Science and Technology, Brazil.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Malaria Centre

Teaching


Founder, MSc in the Control of Infectious Diseases (CID), Course/Programme Director for 20 years, now deputising for current Programme Director, Matthew Yeo.

Founder and Course Director of previous MSc course in Molecular Biology of Infectious Diseases.

Module Organiser:module 3125 Introduction to Infectious Disease Agents and their Control (IDAC), 11 week term 1 core teaching for MSc CID. Tutor, MSc project supervisor, MSc CID Exam Board and Course Committee, internal and external teaching on Medical Parasitology, Molecular Epidemiology, Vector Control, Diagnostics, principally in the context of South American Trypanosomiasis (Chagas disease) and leishhmaniasis.

PhD supervisor, of >35 successful students, currently 5 students.

Research

Research is primarily on molecular epidemiology and taxonomy of Leishmania and Trypanosoma cruzi, improvement of control strategies, including both fundamental experimental and field research, and on diagnostics development.

Examples of achievements in research (with collaborators/co-authors)

  • Described the biochemical and genetic heterogeneity of Trypanosoma cruzi (Nature). 
  • Pioneered the concept of separate, overlapping and enzootic transmission cycles as applied to the epidemiology of Chagas disease.
  • Described the ecotopes of several Amazonian triatomine species and explained the absence of endemic (domestic) Chagas disease in the Amazon Basin.
  • Discovered the new triatomine species Rhodnius paraensis in Amazon forest. 
  • Showed that Rhodnius prolixus in Venezuela reinvades houses (with Sinead Fitzpatrick).
  • Demonstrated that Trypanosoma rangeli is widely distributed in Brazil, and described its hosts and vectors. 
  • Linked genetic lineages of T. cruzi to clinical diversity (Lancet, and Clin. Inf. Dis.).
  • Contributed to the Southern Cone Initiative to control Chagas disease.
  • First experimental proof of genetic exchange in T. cruzi (Nature).
  • Demonstrated synonomy of Leishmania chagasi and Leishmania infantum.
  • Evidence of recombination in Leishmania (Viannia) populations.
  • Drew attention to the threat of visceral leishmaniasis/HIV co-infection (Nature).
  • Visualisation of hybrid transgenic Leishmania in sand flies.
  • Extensive molecular epidemiological studies of T. cruzi and Leishmania.
  • RDT for T. cruzi clinical association studies and reservoir discovery (Clin. Inf. Dis.).
  • RDT for discrimination of cure versus relapse of visceral leishmaniasis (Clin. Inf. Dis.)
  • Analysis of Leishmania hybrids derived from two sand fly species (unpublished).
  • Devised spool-and-line mammal tracking, for ecological studies of mammals.
Research Area
Diagnostics
Helminths
Insects
Parasites
Trypanosomes
Disease control
Protozoa
Schools
Vector control
Discipline
Genomics
Immunoepidemiology
Molecular epidemiology
Epidemiology
Genetics
Immunology
Molecular biology
Parasitology
Vector biology
Entomology
Disease and Health Conditions
Cardiovascular disease
Chronic disease
Infectious disease
Malaria
African trypanosomiasis
Chagas Disease
Emerging Infectious Disease
Neglected Tropical Diseases (NTDs)
Schistosomiasis
Tropical diseases
Vector borne disease
Zoonotic disease
Leishmaniasis
Human African trypanosomiasis
Soil-transmitted helminths
Country
Argentina
Belgium
Bangladesh
Bolivia
Brazil
Chile
Democratic Republic of the Congo
Colombia
Czech Republic
Ecuador
Spain
Guatemala
Kenya
Nepal
Peru
Portugal
Paraguay
Sudan
South Sudan
United States of America
Venezuela
Region
Latin America & Caribbean (developing only)
Latin America & Caribbean (all income levels)
Least developed countries: UN classification
Middle East & North Africa (developing only)
South Asia
Sub-Saharan Africa (developing only)

Selected Publications

Under pressure: phenotypic divergence and convergence associated with microhabitat adaptations in Triatominae.
Abad-Franch F; Monteiro FA; Pavan MG; Patterson JS; Bargues MD; Zuriaga MÁ; Aguilar M; Beard CB; Mas-Coma S; Miles MA
2021
Parasites & vectors
Consolidated results of dogs in the 2018 and 2019 studies
Fujisawa K; Silcott-Niles C; Simonson P; Lamattina D; Humeres CA; Bhattacharyya T; Mertens P; Thunissen C; O'Rourke V; Pańczuk M
2021
Emergent canine visceral leishmaniasis in Argentina: Comparative diagnostics and relevance to proliferation of human disease.
Fujisawa K; Silcott-Niles C; Simonson P; Lamattina D; Humeres CA; Bhattacharyya T; Mertens P; Thunissen C; O'Rourke V; Pańczuk M
2021
PLoS neglected tropical diseases
Additional file 5 of Assessing antibody decline after chemotherapy of early chronic Chagas disease patients
Murphy N; Cardinal MV; Bhattacharyya T; Enriquez GF; Macchiaverna NP; Alvedro A; Freilij H; Martinez de Salazar P; Molina I; Mertens P
2021
Assessing antibody decline after chemotherapy of early chronic Chagas disease patients.
Murphy N; Cardinal MV; Bhattacharyya T; Enriquez GF; Macchiaverna NP; Alvedro A; Freilij H; Martinez de Salazar P; Molina I; Mertens P
2021
Parasites & vectors
Congenital Chagas disease in Santa Cruz Department, Bolivia, is dominated by Trypanosoma cruzi lineage V.
Sanchez L; Messenger LA; Bhattacharyya T; Gilman RH; Mayta H; Colanzi R; Bozo R; Verástegui M; Miles MA; Bern C
2021
Transactions of the Royal Society of Tropical Medicine and Hygiene
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