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Dr Michael Marks

MRCP DTM&H PhD

Associate Professor

Room
359

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I am an NIHR Clinical Lecturer in infectious diseases. My Phd, which was funded by the Wellcome Trust, focused on understanding the impact of azithromycin mass administration on treponemal infections as part of a strategy to eliminate yaws in the Solomon Islands including work on disease mapping and the evaluation of diagnostic tests. I was a lead investigator on a WHO sponsored trial of treatment of yaws in Ghana and Papua New Guinea and collaborate with Oriol Mitjà on studies to optimise community treatment strategies for yaws in PNG. I am the principal investigator on a new EDCTP evaluation of a LAMP assay for yaws (2020-2022) in Ghana, Cote d’Ivoire and Cameroon.

Following my PhD my research interests have expanded to include all of the human treponematoses including both Treponema pallidum subsp. pallidum (the causative agent of syphilis) whilst continuing my interest in T.pallidum subsp. pertenue (the causative agent of yaws). I collaborate with Professor Nick Thomson on the application of next-generation sequencing tools to our understanding in these important diseases.

I am involved in a number of studies on the epidemiology and control of scabies, which is endemic in the Pacific region and has recently been adopted as an NTD by the World Health Organization. I collaborate with Andrew Steer, in Melbourne, and John Kaldor, in Sydney, on a number of studies to better understand the use of mass treatment strategies to control scabies in endemic communities.

As well as work on these specific NTDs I am interested in strategies for the integrated control of neglected tropical diseases. I am a lead investigator on several studies exploring the possibility of combining MDA programmes for multiple NTDs into a single intervention in Ethiopia and Papua New Guinea. Along with Rachel PullanSteve Walker and others I am a lead investigator on an NIHR funded project (2019-2023) on integrated control strategies for NTDs of the skin including buruli ulcer, yaws, cutaneous leishmaniasis and leprosy in Ghana and Ethiopia.

I am a member of the World Health Organization Department of Control of Neglected Tropical Diseases Diagnostic Technical Advisory Group and am on the executive steering committee for the International Alliance for the Control of Scabies.

Alongside my research work at LSHTM, I worked with Chrissy Roberts to establish and run the ODK@LSHTM service which supports the uptake of the ODK electronic data collection platform in research projects run by LSHTM worldwide.

Details of grants and work I have been involved in are also available on ORC-ID

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Teaching

I am the deputy module director of the recently established Neglected Tropical Diseases MSc module. I am on the course committee and teach on both the London Diploma in Tropical Medicine and Hygiene (DTM&H) and the East African DTM&H (LSHTM). I also sit on the exam board of the Tropical Medicine and International Health MSc.

Research

  • Yaws: Epidemiology, community treatment strategies, diagnostics and modelling
  • Scabies: Epidemiology, community treatment strategies
  • NTDs: Integrated Case Finding & Mass Drug Administration Strategies
  • Treponema pallidum: Sequencing, host-pathogen interactions
Research Area
Clinical care
Diagnostics
Infectious disease policy
Sexual health
Disease control
Global Health
Impact evaluation
Mobile technologies
Implementation research
Randomised controlled trials
Discipline
Bacteriology
Epidemiology
Medicine
Microbiology
Mathematical modelling
Disease and Health Conditions
Infectious disease
Trachoma
Syphilis
Emerging Infectious Disease
Neglected Tropical Diseases (NTDs)
Sexually transmitted infection
Skin disease
Tropical diseases
Country
Cote d'Ivoire
Cameroon
Ethiopia
Ghana
The Gambia
Liberia
Papua New Guinea
Solomon Islands
Vanuatu
Region
Pacific island small states
Sub-Saharan Africa (developing only)

Selected Publications

Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages.
Beale MA; Marks M; Sahi SK; Tantalo LC; Nori AV; French P; Lukehart SA; Marra CM; Thomson NR
2019
Nature communications
The public health control of scabies: priorities for research and action.
Engelman D; Cantey PT; Marks M; Solomon AW; Chang AY; Chosidow O; Enbiale W; Engels D; Hay RJ; Hendrickx D
2019
LANCET
Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: a single-arm community intervention trial.
Romani L; Marks M; Sokana O; Nasi T; Kamoriki B; Cordell B; Wand H; Whitfeld MJ; Engelman D; Solomon AW
2019
The Lancet. Infectious diseases
Syphilis self-testing: a nationwide pragmatic study among men who have sex with men in China.
Wang C; Cheng W; Li C; Tang W; Ong JJ; Smith MK; Fu H; Marks M; Nie J; Zheng H
2019
Clinical infectious diseases
Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.
Marks M; Mitjà O; Bottomley C; Kwakye C; Houinei W; Bauri M; Adwere P; Abdulai AA; Dua F; Boateng L
2018
The Lancet Global health
Randomized Trial of Community Treatment With Azithromycin and Ivermectin Mass Drug Administration for Control of Scabies and Impetigo.
Marks M; Toloka H; Baker C; Kositz C; Asugeni J; Puiahi E; Asugeni R; Azzopardi K; Diau J; Kaldor JM
2018
Clinical infectious diseases
Feasibility and safety of mass drug coadministration with azithromycin and ivermectin for the control of neglected tropical diseases: a single-arm intervention trial.
Romani L; Marks M; Sokana O; Nasi T; Kamoriki B; Wand H; Whitfeld MJ; Engelman D; Solomon AW; Steer AC
2018
The Lancet Global health
Targeted Treatment of Yaws With Household Contact Tracing: How Much Do We Miss?
Dyson L; Marks M; Crook OM; Sokana O; Solomon AW; Bishop A; Mabey DCW; Hollingsworth TD
2017
American journal of epidemiology
Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws.
Marks M; Yin Y-P; Chen X-S; Castro A; Causer L; Guy R; Wangnapi R; Mitjà O; Aziz A; Castro R
2016
Clinical infectious diseases
A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control.
Ghinai R; El-Duah P; Chi K-H; Pillay A; Solomon AW; Bailey RL; Agana N; Mabey DCW; Chen C-Y; Adu-Sarkodie Y
2015
PLoS neglected tropical diseases
Challenges and key research questions for yaws eradication.
Marks M; Mitjà O; Vestergaard LS; Pillay A; Knauf S; Chen C-Y; Bassat Q; Martin DL; Fegan D; Taleo F
2015
The Lancet infectious diseases
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws.
Marks M; Vahi V; Sokana O; Chi K-H; Puiahi E; Kilua G; Pillay A; Dalipanda T; Bottomley C; Solomon AW
2015
PLoS neglected tropical diseases
Global epidemiology of yaws: a systematic review.
Mitjà O; Marks M; Konan DJP; Ayelo G; Gonzalez-Beiras C; Boua B; Houinei W; Kobara Y; Tabah EN; Nsiire A
2015
The Lancet Global health
Haemophilus ducreyi associated with skin ulcers among children, Solomon Islands.
Marks M; Chi K-H; Vahi V; Pillay A; Sokana O; Pavluck A; Mabey DC; Chen CY; Solomon AW
2014
Emerging infectious diseases
See more Publications