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Dr Michael Marks

MRCP DTM&H PhD

Associate Professor

Room
358

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I am an Associate Professor at LSHTM and an Honorary Consultant in Infectious Diseases at the Hospital for Tropical Diseases, University College London Hospital.

Currently my research spans three main areas:

  1. Neglected tropical diseases
  2. Sexually transmitted infections
  3. COVID
  My work on NTDs and STIs is linked by a particular focus on Treponema pallidum the causative agent of syphilis & yaws.


Neglected Tropical Diseases

Yaws: My Phd, which was funded by the Wellcome Trust, focused on understanding the impact of azithromycin mass administration on treponemal infections as part of a strategy to eliminate yaws in the Solomon Islands including work on disease mapping and the evaluation of diagnostic tests. I was a lead investigator on a WHO sponsored trial of treatment of yaws in Ghana and Papua New Guinea and collaborate with Oriol Mitjà on studies to optimise community treatment strategies for yaws in PNG. I am the principal investigator on a new EDCTP evaluation of a LAMP assay for yaws (2020-2022) in Ghana, Cote d’Ivoire and Cameroon.

Scabies: I am involved in a number of studies on the epidemiology and control of scabies, which is endemic in the Pacific region and has recently been adopted as an NTD by the World Health Organization. I collaborate with Andrew Steer, in Melbourne, and John Kaldor, in Sydney, on a number of studies to better understand the use of mass treatment strategies to control scabies in endemic communities. My work on scabies has led on to a broader research interest in Group A Streptococcal (GAS) disease which is a major cause of morbidity and mortality worldwide. I collaborate with Thushan de Silva at the University of Sheffield and MRC Unit the Gambia on the epidemiology and control of GAS.

Integrated NTD control: As well as work on these specific NTDs I am interested in strategies for the integrated control of neglected tropical diseases. I am a lead investigator on several studies exploring the possibility of combining MDA programmes for multiple NTDs into a single intervention in Ethiopia and Papua New Guinea. Along with Rachel PullanSteve Walker and others I am a lead investigator on the NIHR funded SHARP project (2019-2023) on integrated control strategies for NTDs of the skin including buruli ulcer, yaws, cutaneous leishmaniasis and leprosy in Ghana and Ethiopia.

I am a member of the World Health Organization Department of Control of Neglected Tropical Diseases Diagnostic Technical Advisory Group and am the current Vice-Chair of the International Alliance for the Control of Scabies.

Sexually Transmitted Infections

Syphilis: In collaboration with Professor Nick Thomson a major area of interest has been the application of next-generation sequencing approaches to better understand the epidemiology of syphilis. This has included conducting the largest multi-country whole genome sequencing study of syphilis to date. We have now expanded this work to include a focus on genital ulcer disease across Argentina, Botswana, Ghana, Uganda and Zimbabwe funded by the Gates Foundation which will provide vital data on global genomic diversity of this important sexually transmitted pathogen.

In many LMICs syphilis testing remains limited to the antenatal setting and key groups such as men who have sex with men (MSM) are often unable to access testing. In order to improve outcomes for marginalised groups I work with Joe Tucker to evaluate innovative strategies, such as self-testing, to improve syphilis testing rates amongst high risk groups in China and Zimbabwe. 

STI Diagnostics: With Rashida Ferrand and Katharina Kranzer I am currently supervising a Wellcome Trust funded PhD on integrating near-patient molecular diagnostics for STIs into antenatal care in Zimbabwe.

Sexual & Reproductive Health: I am a member of the I-SHARE consortium. I-SHARE examines the impact of the COVID-19 crisis on sexual and reproductive health across a diverse range of low-income, middle-income, and high-income countries. 

I am a member of the steering committee of the STI Research Interest Group at LSHTM.

COVID

Post-COVID: I am a member of the national management committee of PHOSP, a large UK cohort study exploring long-term outcomes of patients who were hospitalised with COVID-19. Linked to this I am a co-investigator on a grant led by Andy Briggs evaluating health system pathways and the economic impact on patients hospitalised with COVID and on the OpenPROMPT study led by Roz Eggo on the economic impact on patients with COVID managed in the community.

COVID Transmission: I am the PI on an MRC/NIHR funded study which has taken a multi-disciplinary approach to understanding transmission of COVID in minority populations in the UK and how public health responses can best be contexualised to the needs of these groups. I am also the co-ordinator of an EDCTP funded project looking to strengthen surveillance of COVID-19 in Ghana.

 

OTHER ACTIVITIES

Alongside my research work at LSHTM, I worked with Chrissy Roberts to establish and run the ODK@LSHTM service which supports the uptake of the ODK electronic data collection platform in research projects run by LSHTM worldwide. Our Emergency Data Kit project supported the role out of Ebola Vaccination in the DRC

Details of grants and work I have been involved in are also available on ORC-ID

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am the co-module director of the Neglected Tropical Diseases MSc module. I am on the course committee and teach on both the London Diploma in Tropical Medicine and Hygiene (DTM&H) and the East African DTM&H (LSHTM). I also sit on the exam board of the Tropical Medicine and International Health MSc

I currently supervise PhD students working on:

  • The impact of MDA for the control of malaria on other diseases
  • The evaluation of new diagnostics for yaws
  • Haemophilus ducreyi as a cause of cutaenous ulcers in Cameroon
  • Transmission of Group A Streptococcus in the Gambia
  • Near patient diagnostics for STIs in Zimbabwe

Research

  • Yaws: Epidemiology, community treatment strategies, diagnostics and modelling
  • Syphilis & STIs: Sequencing, host-pathogen interactions, Innovative approaches to testing
  • Scabies & Group A Streptococcus: Epidemiology, community treatment strategies
  • NTDs: Integrated Case Finding & Mass Drug Administration Strategies
  • COVID-19: Transmission & epidemiology, Post-COVID Recovery
Research Area
Clinical care
Diagnostics
Infectious disease policy
Sexual health
Disease control
Global Health
Impact evaluation
Mobile technologies
Implementation research
Randomised controlled trials
Discipline
Bacteriology
Epidemiology
Medicine
Microbiology
Mathematical modelling
Operational research
Disease and Health Conditions
Infectious disease
Sexually transmitted disease
Trachoma
Syphilis
Emerging Infectious Disease
Neglected Tropical Diseases (NTDs)
Sexually transmitted infection
Skin disease
Tropical diseases
Country
Cote d'Ivoire
Cameroon
Ethiopia
Ghana
The Gambia
Liberia
Papua New Guinea
Solomon Islands
Zimbabwe
Region
Pacific island small states
Sub-Saharan Africa (developing only)

Selected Publications

Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication.
John LN; Beiras CG; Houinei W; Medappa M; Sabok M; Kolmau R; Jonathan E; Maika E; Wangi JK; Pospíšilová P
2022
The New England journal of medicine
Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis.
Beale MA; Marks M; Cole MJ; Lee M-K; Pitt R; Ruis C; Balla E; Crucitti T; Ewens M; Fernández-Naval C
2021
Nature Microbiology
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.
Evans RA; McAuley H; Harrison EM; Shikotra A; Singapuri A; Sereno M; Elneima O; Docherty AB; Lone NI; Leavy OC
2021
The Lancet. Respiratory medicine
Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study.
Marks M; Millat-Martinez P; Ouchi D; Roberts CH; Alemany A; Corbacho-Monné M; Ubals M; Tobias A; Tebé C; Ballana E
2021
The Lancet. Infectious diseases
Uptake of and factors associated with testing for sexually transmitted infections in community-based settings among youth in Zimbabwe: a mixed-methods study.
Martin K; Olaru ID; Buwu N; Bandason T; Marks M; Dauya E; Muzangwa J; Mabey D; Dziva Chikwari C; Francis SC
2021
The Lancet. Child & adolescent health
Pharmacokinetic and safety study of co-administration of albendazole, diethylcarbamazine, Ivermectin and azithromycin for the integrated treatment of Neglected Tropical Diseases.
John LN; Bjerum C; Martinez PM; Likia R; Silus L; Wali C; Elizah A; Chhonker YS; Bala V; King CL
2020
Clinical Infectious Diseases
The public health control of scabies: priorities for research and action.
Engelman D; Cantey PT; Marks M; Solomon AW; Chang AY; Chosidow O; Enbiale W; Engels D; Hay RJ; Hendrickx D
2019
LANCET
Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: a single-arm community intervention trial.
Romani L; Marks M; Sokana O; Nasi T; Kamoriki B; Cordell B; Wand H; Whitfeld MJ; Engelman D; Solomon AW
2019
The Lancet. Infectious diseases
Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.
Marks M; Mitjà O; Bottomley C; Kwakye C; Houinei W; Bauri M; Adwere P; Abdulai AA; Dua F; Boateng L
2018
The Lancet Global health
Randomized Trial of Community Treatment With Azithromycin and Ivermectin Mass Drug Administration for Control of Scabies and Impetigo.
Marks M; Toloka H; Baker C; Kositz C; Asugeni J; Puiahi E; Asugeni R; Azzopardi K; Diau J; Kaldor JM
2018
Clinical infectious diseases
Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws.
Marks M; Yin Y-P; Chen X-S; Castro A; Causer L; Guy R; Wangnapi R; Mitjà O; Aziz A; Castro R
2016
Clinical infectious diseases
Challenges and key research questions for yaws eradication.
Marks M; Mitjà O; Vestergaard LS; Pillay A; Knauf S; Chen C-Y; Bassat Q; Martin DL; Fegan D; Taleo F
2015
The Lancet infectious diseases
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