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Dr Clemence Leyrat

MSc PhD

Assistant Professor
in Statistics

Room
G 36

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44(0)207 927 2169

After studying cognitive sciences at the University of Bordeaux (France) from 2005 to 2009, I obtained an MSc in Biostatistics at the Bordeaux school of Public Health in 2010. I then completed a PhD in Biostatistics at the University Paris Diderot in 2014 on the use of propensity score methods for cluster randomised trials, under the supervision of Bruno Giraudeau. During my PhD, I was involved in the statistical analysis of observational studies and clinical trials and taught statistics applied to biology and psychology. From 2014 to 2015, I did post-doctoral research in collaboration with the Hospital of Tours (INSERM CIC 1415 France) and Queen Mary University of London (Pragmatic Clinical Trial Unit).

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Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Centres

Statistical Methodology

Research

 I am currently working on handling missing data for propensity score estimation in the context of electronic health records. I am also interested in the methodology of cluster randomised trials and causal inference (CACE analyses, instrumental variables).

Research Area
Clinical trials
Electronic health records
Randomised controlled trials
Discipline
Statistics

Selected Publications

Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.
Crellin, E. ; Mansfield, K.E. ; Leyrat, C. ; Nitsch, D. ; Douglas, I.J. ; Root, A. ; Williamson, E. ; Smeeth, L. ; Tomlinson, L.A. ;
2018
BMJ
Propensity score analysis with partially observed covariates: How should multiple imputation be used?
Leyrat, C. ; Seaman, S.R. ; White, I.R. ; Douglas, I. ; Smeeth, L. ; Kim, J. ; Resche-Rigon, M. ; Carpenter, J.R. ; Williamson, E.J. ;
2017
Stat Methods Med Res
Cluster randomized trials with a small number of clusters: which analyses should be used?
Leyrat, C. ; Morgan, K.E. ; Leurent, B. ; Kahan, B.C. ;
2017
Int J Epidemiol
Performance of principal scores to estimate the marginal compliers causal effect of an intervention.
Porcher, R. ; Leyrat, C. ; Baron, G. ; Giraudeau, B. ; Boutron, I. ;
2016
Stat Med
Propensity score to detect baseline imbalance in cluster randomized trials: the role of the c-statistic.
Leyrat, C. ; Caille, A. ; Foucher, Y. ; Giraudeau, B. ;
2016
BMC Med Res Methodol
Timeline cluster: a graphical tool to identify risk of bias in cluster randomised trials.
Caille, A. ; Kerry, S. ; Tavernier, E. ; Leyrat, C. ; Eldridge, S. ; Giraudeau, B. ;
2016
BMJ
Increased risk of type I errors in cluster randomised trials with small or medium numbers of clusters: a review, reanalysis, and simulation study.
Kahan, B.C. ; Forbes, G. ; Ali, Y. ; Jairath, V. ; Bremner, S. ; Harhay, M.O. ; Hooper, R. ; Wright, N. ; Eldridge, S.M. ; Leyrat, C. ;
2016
Trials
See all Dr Clemence Leyrat's Publications