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Professor John Kelly

BSc PhD

Professor
of Molecular Biology

Room
Room 390

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2330

Research area: The molecular biology of parasitic protozoa

My lab focuses on three main areas:

  • Development of new genetic tools for functional studies on Trypanosoma cruzi
  • Mechanisms of drug action and resistance in Chagas disease
  • Understanding Chagas disease pathogenesis 

Funding: Global Health Innovative Technology (GHIT) Fund, Australian Research Council, Drugs for Neglected Diseases initiative (DNDi), GSK

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Pathogen Molecular Biology

Teaching

As part of the Masters course 'Molecular Biology of Infectious Diseases', I teach on a 5 week study module entitled 'Advanced Training in Molecular Biology' . The module is built round an appropriate central research theme and offers training in laboratory skills, bioinformatics and scientific writing.

Research

  The parasitic protozoa Trypanosoma cruzi and Trypanosoma brucei are responsible for two major tropical infections, Chagas disease and African trypanosomiasis, respectively. These diseases represent a major public health problem in regions of the world least able to deal with the associated economic burden. Advances by ourselves and others have led to the development of a wide range of genetic tools that can be used to address fundamental biological questions associated with these important pathogens. In addition, the output of the trypanosomatid genome projects, together with major advances in imaging technology is providing a research framework where rapid progress can be expected. We are exploiting these new approaches and opportunities to gain greater understanding of the mechanisms of drug action and resistance, and disease pathogenesis. In collaboration with biologists, biochemists and medicinal chemists, we are contributing to the Chagas disease drug discovery pipeline, as well as providing the community with new functional genomic tools. These multidisciplinary approaches, which bring together of both academic and industrial partners, is now widely seen as the way ahead to provide better treatment for these previously ‘Neglected Diseases’.

 

 

 

Research Area
Drug discovery and development
Drug resistance
Parasites
Trypanosomes
Methodology
Protozoa
Discipline
Genomics
Immunopathology
Biochemistry
Cell biology
Molecular biology
Parasitology
Pathology
Vaccinology
Disease and Health Conditions
Infectious disease
African trypanosomiasis
Chagas Disease
Tropical diseases
Country
Argentina
Brazil
Colombia
Mexico
Venezuela, RB
Region
Latin America & Caribbean (all income levels)
Sub-Saharan Africa (developing only)

Selected Publications

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
Costa, F.C. ; Francisco, A.F. ; Jayawardhana, S. ; Calderano, S.G. ; Lewis, M.D. ; Olmo, F. ; Beneke, T. ; Gluenz, E. ; Sunter, J. ; Dean, S. ; Kelly, J.M. ; Taylor, M.C. ;
2018
PLoS Negl Trop Dis
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Campos, M.C. ; Phelan, J. ; Francisco, A.F. ; Taylor, M.C. ; Lewis, M.D. ; Pain, A. ; Clark, T.G. ; Kelly, J.M. ;
2017
Sci Rep
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Lewis, M.D. ; Francisco, A.F. ; Taylor, M.C. ; Jayawardhana, S. ; Kelly, J.M. ;
2016
Cell Microbiol
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Francisco, A.F. ; Jayawardhana, S. ; Lewis, M.D. ; White, K.L. ; Shackleford, D.M. ; Chen, G. ; Saunders, J. ; Osuna-Cabello, M. ; Read, K.D. ; Charman, S.A. ; Chatelain, E. ; Kelly, J.M. ;
2016
Sci Rep
The limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging.
Fortes Francisco, A. ; Lewis, M.D. ; Jayawardhana, S. ; Taylor, M.C. ; Chatelain, E. ; Kelly, J.M. ;
2015
Antimicrob Agents Chemother
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
Lewis, M.D.; Fortes Francisco, A.; Taylor, M.C.; Burrell-Saward, H.; McLatchie, A.P.; Miles, M.A.; Kelly, J.M.;
2014
Cell Microbiol
Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population.
Mejia, A.M.; Hall, B.S.; Taylor, M.C.; Gómez-Palacio, A.; Wilkinson, S.R.; Triana-Chávez, O.; Kelly, J.M.;
2012
J Infect Dis
Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei.
Obado, S.O.; Bot, C.; Echeverry, M.C.; Bayona, J.C.; Alvarez, V.E.; Taylor, M.C.; Kelly, J.M.;
2011
Nucleic Acids Res
See all Professor John Kelly's Publications