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Julius Hafalla

BSc MSc PhD

Associate Professor
of Immunology and Royal Society University Research Fellow

Room
233

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7958 8129

Fax.
+44 (0)20 7958 8129

Julius Hafalla obtained his BSc in Molecular Biology and Biotechnology (cum laude) from the University of the Philippines – Diliman. He then worked as a Research Assistant at the Research Institute for Tropical Medicine (Philippines) and as a Fogarty Fellow at the International Health Institute of Brown University (USA). Julius obtained his MSc and PhD in Basic Medical Sciences at New York University (USA), where he investigated the development of T cell responses to malaria liver stage infection. He also did post-doctoral work in parasitology, immunology and pre-clinical vaccine development at New York University.

In 2005, Julius joined the LSHTM as a Royal Society Incoming Fellow to study the regulation of pathogenic responses during blood stage malaria infections, and as a Wellcome Trust Visiting Fellow in Public Health and Tropical Medicine to examine cellular immune responses to malaria in Thailand and Tanzania.

In 2008, Julius was awarded a Royal Society University Research Fellowship, which was renewed in 2013. He was appointed as a Senior Lecturer in Immunology in 2013.

Affiliations

Immunology and Infection Department
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre
Vaccine Centre

Teaching

MSc Immunology of Infectious Diseases – core immunology, advanced immunology and parasite immunology

MSc Medical Parasitology – core parasitology

MSc Medical Microbiology – core bacteriology

MSc Molecular Biology of Infectious Diseases – research progress and applications

Research

Julius Hafalla's research investigates factors that govern the magnitude, efficiency and long-term maintenance of protective immune responses to malaria pre-erythrocytic stages. He has an interest in understanding protective and pathological mechanisms involved during malaria blood stage infection. He is involved in infectious disease research in The Philippines.

Research Area
Innate immunity
Parasites
T-cell immunology
Vaccines
Immunisation
Protozoa
Discipline
Genomics
Immunopathology
Cell biology
Genetics
Immunology
Molecular biology
Parasitology
Bioinformatics
Disease and Health Conditions
Infectious disease
Malaria
Dengue
Tropical diseases
Region
East Asia & Pacific (developing only)
Latin America & Caribbean (developing only)
Sub-Saharan Africa (developing only)

Selected Publications

Identification of Targets of CD8(+) T Cell Responses to Malaria Liver Stages by Genome-wide Epitope Profiling.
Hafalla, J.C. ; Bauza, K. ; Friesen, J. ; Gonzalez-Aseguinolaza, G. ; Hill, A.V. ; Matuschewski, K. ;
PLoS Pathog
The CTLA-4 and PD-1/PD-L1 Inhibitory Pathways Independently Regulate Host Resistance to Plasmodium-induced Acute Immune Pathology.
Hafalla, J.C. ; Claser, C. ; Couper, K.N. ; Grau, G.E. ; Renia, L. ; de Souza, J.B. ; Riley, E.M. ;
PLoS Pathog
Antigen-Specific IL-2 Secretion Correlates with NK Cell Responses after Immunization of Tanzanian Children with the RTS,S/AS01 Malaria Vaccine.
Horowitz, A.; Hafalla, J.C.; King, E.; Lusingu, J.; Dekker, D.; Leach, A.; Moris, P.; Cohen, J.; Vekemans, J.; Villafana, T.; Corran, P.H.; Bejon, P.; Drakeley, C.J.; von Seidlein, L.; Riley, E.M.;
J Immunol
Cell biology and immunology of malaria.
Hafalla, J.C. ; Silvie, O. ; Matuschewski, K. ;
Immunol Rev
Experimental cerebral malaria develops independently of Card9 signalling.
Hafalla, J.C. ; Burgold, J. ; Dorhoi, A. ; Gross, O. ; Ruland, J. ; Kaufmann, S.H. ; Matuschewski, K. ;
Infect Immun
Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax.
Wipasa, J.; Suphavilai, C.; Okell, L.C.; Cook, J.; Corran, P.H.; Thaikla, K.; Liewsaree, W.; Riley, E.M.; Hafalla, J.C.;
PLoS Pathog
Natural immunization against malaria: causal prophylaxis with antibiotics.
Friesen, J. ; Silvie, O. ; Putrianti, E.D. ; Hafalla, J.C. ; Matuschewski, K. ; Borrmann, S. ;
Sci Transl Med
See all Julius Hafalla's Publications